Goodnight, Syed.
Just remember that you will have to be able to repeat what you are able to do often enough to show that you're not just guessing.
Say, you are given a preparation. You have to say whether it is the real remedy or the blank (or remedy A as opposed to remedy B). You do whatever you like, and you give your answer. So, you have a 50% chance of guessing right! The JREF isn't going to give you the money on a 50-50 guess! Someone would already have won it for correctly predicting whether a coin would come up heads or tails if it was that easy!
No, you have to get it right (for the preliminary trial) to a level of confidence of (I understand) 1 in 1,000.
This is not as hard as it sounds, and it doesn't mean you have to do anything like 1,000 tests. Probably 15 would do.
For the remedy proving (or making someone ill with it, which I think is much the same thing), that should be quite easy. Just do it yourself, then like I said nobody will be demanding a share of the money. State your remedy, that you can tell from the stock solvent or pills. Or state your two remedies, that you can distinguish one from the other. Fifteen times you are given either, at random, not knowing which. Fifteen times, you guess correctly.
YOU'VE PASSED!
Or if you want to use cures, again I can see a fairly simple way.
Find 15 volunteers, with illnesses you're sure you can cure. Dammit, I'll volunteer myself if you get that far! Decide which remedy is the right one for each person. Then ask that you be given either the right remedy, or the untreated solvent/sugar pills. Treat the patient. Decide whether you were given the real remedy according to whether the patient is better or not.
Get it right 15 times, YOU'VE PASSED!
OK, that's only the preliminary test, you'd have to do it again with a few more repetitions for the definite test for the million dollars. But you'd only need maybe 20 trials for that. Do either of the above, 20 times, get it right 20 times, and you're a dollar millionaire! Congratulations! (Even if you have to share it with your subjects, it's still a lot of loot.)
Actually, I think the suggestions of 15 and 20 subjects for the two phases might even be too demanding. If you can get it right
every time it's probably a bit less than that. There are sure to be statisticians who will be able to keep you right on that one. I think 15 and 20 respectively actually allows you one or two mistakes.
So there you go. I can't speak for the JREF of course, but having followed a number of attempts at the prize, I'm pretty sure that if you put forward either of those protocols they'll find them acceptable.
See you in the "Million Dollar Challenge" forum area, if you like - that's where people often like to discuss a serious application while they're getting ready.
I wonder if Syed will last longer than Wellfed?
Rolfe.