Questions about Hyperinsulinemia/Diabetes

Kumar said:
Insulin is a big molecule. Can't then it be filtered into kidneys from blood?
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[leaps up out of computer chair, runs across dining room, bangs head against the wall repeatedly]

Kumar...if the kidneys could filter insulin out of the blood, then there wouldn't be any point in diabetics TAKING insulin, now would there?

Because the kidneys would just filter it out.

Hellooooo?

Yeesh. :rolleyes:



West India Quay. Chernoff Defense.

Somebody go pay the pizza kid...
 
Goshawk;1272529 Kumar...if the kidneys could filter insulin out of the blood said:
then there wouldn't be any point in diabetics TAKING insulin, now would there?[/b]

Because the kidneys would just filter it out.
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Would you like to read more in this topic about it or any other can expain it to you? We take many substances which are still filtered.
 
Goshaswk, we just went through this not long ago, and I googled/pubmedded it. My recollection is that in fact insulin is small enough that it does get filtered out through the kidney. It doesn't actually appear in the urine; it is taken up and destroyed by the tubule cells. It is also taken up and destroyed by the cells on which it acts. I don't know what the rate is.

The depressing part is that my brain is a sieve since menopause (or some other cause). Lately it filters out knowledge at such a rapid rate that I'd have to go look it up again to be sure. Instead, I think I'll just bang my head against the wall in despair.
 
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flume said:
Goshaswk, we just went through this not long ago, and I googled/pubmedded it. My recollection is that in fact insulin is small enough that it does get filtered out through the kidney. It doesn't actually appear in the urine; it is taken up and destroyed by the tubule cells. It is also taken up and destroyed by the cells on which it acts. I don't know what the rate is.
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I don't recall that we found it was filtered. It's too big. I thought we'd established that there was some uptake and metabolism of insulin by the tubular cells, that was all.

Of course, my memory may be no letter than yours.

Rolfe.

Oops, sorry, I forgot.

Chalfont & Latimer
 
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Rolfe said:
I don't recall that we found it was filtered. It's too big. I thought we'd established that there was some uptake and metabolism of insulin by the tubular cells, that was all.
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Whether this much filteration is meant in normal health or also in diabetes with IR?

If big molecule, what about its filteration in ECF from blood?
 
>>>>BURP!<<<<

Pardon.

Blast that Diet Coke...

OK, seeing as we are still Jarkarta, Monkey is not in Nib (yet), Hans has the locker key... It's getting complicated - a good game! If I set the JPT to 300 degrees, configuration is set for optimal climb rate, advance the power, and release the brakes...

Darn. Low numbers...

Alperton, en passant too. I was hoping for better...
 
MRC_Hans said:
PS: Might I interest anybody in the Intercontinental Line game in the Emotions thread
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Ooh, very modren of you. Unfortunately Kumar's gaffe led to a Two Move Mornington Crescent but with you as winner. A bit like Krum getting the snitch, but Ireland still winning.

This game has more subtlety.

Tooting Broadway

I see that putting our moves in bold has the character of an infectious meme. Isn't it interesting that for all the complexity of the underlying game a meta-analysis of its play would be quite interesting? How does this group of players tacitly agree an appopriate set of conventions without explicit negotiation? There's a PhD in that for someone- alll I want is a banana (or, better, a celebratory bottle of banana liquer) and a listing on the acknowledgements page.
 
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Hmmm.

As a new player, I'm not sure if this is allowed by the rules, but what the hay. See if we can mix it up a bit.

Since the key is in play, under Jakarta rules, a reverse becomes a double-reverse in multiple routes, right?

I'll try

Arsenal

And hope I haven't flubbed too badly :)
 
Badly Shaved Monkey said:
Ooh, very modren of you. Unfortunately Kumar's gaffe led to a Two Move Mornington Crescent but with you as winner. A bit like Krum getting the snitch, but Ireland still winning.

This game has more subtlety.

*snip*
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Agreed, but I got Kumar to play, didn't I? Note, btw. that the station he played is in Thailand ;).

Stratford

Not to imply that you didn't notice, BSM, but one subtlety of this game is that now you cannot go east unless you pick up the key I left at Canary Wharf. Good luck! :D

Hans
 
Welcome to...THE GAME!, Huntsman. I see by your avatar you are a deadly serious player too! Good!

Well, with the key still at Canary Wharf, the double reverse (with no flubb) played out, ye'll take the high road and I'll take the low road, leaving me at...

Rotherhithe?? Oh dear.
 
Aha! Double-reversing that (while still avoiding the areas ruled out by Hans's frankly inconsiderate placement of the key) brings me to:

Mortlake.
 
Ahh, Mojo, remember you need not be restricted by the key. All you need to do is to go to Canary Wharf and pick it up. Of course then you are obliged to to go to Camden Town where it fits a baggage locker and open the locker within 4 moves (unless you throw a double six). And in the locker is, of course, as always, a "try your luck" card. And we all know how those are under J rules :D. However, as you know, you are allowed, if you can, to arrive at MT if you can do it within 4 moves after picking up the key.

OK; as I have Limited Special Privileges in the blockade because I am still formally Key Owner, I go

Barbican

(yes, I have been there before, but that is allowed on a minor stop)

Hans
 
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