Questions about Hyperinsulinemia/Diabetes

Have you thought about it? Did you come up with any ideas? Have you read about insulin in evolution? Maybe it would be interesting to you to see how insulin acts and how glucose is transported and stored in a simpler organism than humans.

Yes, I shall see it. About insulin read and also provided good link from wikipedia here. Still, there may be some scope for dynamism.

Why there can't be renal loss of insulin in diabetic patients?
 
Any logic, why we got evolved for insulin need, when it could possible to transport sugar with out it as in intestines?
Try thinking about what the purpose of the whole insulin/glucagon etc. system is.

And no, it's not just to enable cells to absorb glucose.

Back to the game:

Latimer Road
 
Try thinking about what the purpose of the whole insulin/glucagon etc. system is.

And no, it's not just to enable cells to absorb glucose.

Yes, purposes & different functions were given in that link. Some are special purposes for extra load for which hormones are meant. But I am more intested in knowing about its role in normal absorption by cells. Can you tell?
 
Yes, purposes & different functions were given in that link. Some are special purposes for extra load for which hormones are meant. But I am more intested in knowing about its role in normal absorption by cells. Can you tell?
You've already been given ample information about this by posters on this forum. Why not read what's already been posted?
 
Whether hormones are reqired to create hormony in system or to do everything? Is it evolved for imbalanced/emergency need or also for regular/normal requirement--just think first at concept-Adam & Eve's level, for example?



Seven Sisters.
 
You've already been given ample information about this by posters on this forum. Why not read what's already been posted?

I don't understtod as yet, mean not given. Was that information alike information on "renal loss/filteration of insulin" & "Vascular preambilities" etc.?
 
- Insulin:

Insulin requirements are often altered, either being increased due to insulin resistance or decreased due to impairment clearance of circulatory insulin(4).
In uremic patients (both diabetic and no diabetic) insulin secretion by b cells of the pancreas is reduced and the responsiveness of peripheral tissues (e.g muscles) to insulin is depressed. On the other hand the rate of insulin catabolism (renal and extra renal) is decreased and therefore the half life of any insulin present in the circulation is prolonged. Thus insulin should be given in smaller than usual doses. Bolus administration of moderately large intravenous doses (e.g. 15 unit of regular insulin) even when ketoacidosis is present can result in severe hypoglycemia.
http://www.sums.ac.ir/semj/vol4/apr2003/dka&rf.htm

This also suggest as I doubt?

From this link, it is somewhat indicative that acidosis, hyperkalemia, low bicarbonate, hyperosmality may be linked to hyperglycemia. Will taking bicarbonate/bicarbonate antacid help for better control of BG?
 
I don't understtod as yet, mean not given.
"I don't understand what you told me, therefore you didn't tell me anything"? I don't think so, Kumar. :rolleyes:

The information was given to you. The fact that you don't understand the information you were given is not our problem, it's your problem.

Or need arised for the use of their hormones for homeostatis on eating that fruit.:)
You run across those big words while you're Googling, and you toss them in here--do you know what "homeostasis" means?

Goodge Street.
 
"I don't understand what you told me, therefore you didn't tell me anything"? I don't think so, Kumar. :rolleyes:

The information was given to you. The fact that you don't understand the information you were given is not our problem, it's your problem.

When a real information is given, it embed in my mind.


]You run across those big words while you're Googling, and you toss them in here--do you know what "homeostasis" means?

Homeostatis: When the body is working as it should because all of its systems are in balance/harmony.

"Homeostasis is a complex process. It involves continuous monitoring of the internal and external environment and directing the various organ systems to make appropriate changes. This is accomplished by feedback loops in which a change in one environmental factor causes the body to make changes which maintain its internal environment."

Nature's balance: When the nature is working as it should because all of its systems, beings & things are in balance/harmony to each other.

Now question againn;

Or need arised for the use of their hormones for homeostatis on eating that fruit, so the sin?
 
Or need arised for the use of their hormones for homeostatis on eating that fruit, so the sin?

NO it's because they were told NO TOUCHY TOUCHY OR ELSE IT GETS THE HOSE! :mad:

I'm going to play a UWA student pass card for all rail lines in the metro area and have another turn. It's perfectly valid under McCaffery's rules (1950 revised ed.).

Farrington.
 
Kumar,

The best way to regulate blood glucose levels is by what you eat. To regulate blood sugar well, you need to eat a diet that contains complex carbohydrates that are slow release and will sustain blood sugar over longer periods. That is why it is a good idea to eat something such as porridge for breakfast as this is slow release. Eat it with some fruit and you will then get the natural sweetness of the fructose.

If you want to understand this more then you need to look at structure and function. With most things in the body, if you look at the way it is structured, then you can work out its function and the same is true for biochemistry.

If you look at the chemical structure of carbohydrates, simple carbohydrates have shorter chains, which means that they are broken down more quickly by the body. More complex carbohydrates have longer chains and will not be broken down as quickly.

This explains why if you eat a bar of chocolate you will get a sudden burst of energy and then your energy level will drop rapidly and you will want another one. Chocolate is a simple sugar with shorter molecules that are broken down quickly. If you eat a proper meal that contains more complex carbohydrates such as potatoes, some protein and some vegetables, then this all takes longer to break down and hence better blood glucose control.

Eat proper meals during the day and don't miss breakfast. If you want snacks through the day, then pick things such as fruit, dried fruit, nuts and things such as oat cakes rather than biscuits or chocolate. Biscuits and chocolates might be nice, but do contain empty calories. Fruit and nuts contains things that are better for you and that your body needs.

The best way to control blood sugar is with diet, unless of course you are an IDDM, in which case you need insulin. NIDDM's can control their diabetes with diet and many will be told the same thing that I have just told you now.

Everything that you eat must be broken down to glucose, which is the usable form of energy in the body, which is why different foodstuffs will be broken down through different pathways with proteins taking the longest.

As far as I know, Bicarb has little to do with blood sugar regulation and is more involved in pH balance of the blood.
 
Physiotherapist,

Thanks. Do you want to say no need of insulin or oral medicins, if we can control diet bu using coplex carbs(I think according to glycemic index), even during later stages if NIDDM? However, I am bit anxious about insulin's filteration to target cells, insulin resistance & renal insulin loss. Probably, Something may be fishy in these understandings.

Btw, bit out of topic, can you tell itching, massaging with oil without oil effects on our body. Pls tell maximum about itching effects/why we itch & what it effects in body?
 
Trabspot & uptake of glucose

Sorry, double post deleted.
 
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Transport & uptake of glucose

"When food with more carbs is taken, the blood sugar level is increased, Immediately pancreas secretes insulin. Now, the insulin facilitates the transpot of glucose from blood into the cells by increasing the permeability of cell membrane to glucose. Insulin enhanses the uptake of glucose by all the tissues particularily by liver, muscle and adipose tissues. However insulin is not required for glucose uptake in some tissues like brain(except hypothalamus), renal tubules, mucus membrane of intestine and red blood cells.

Glucose transporters-GLUT: Usually glucose is transported inside the cells by sodium-glucose symport pump, another type of transpoter are in most of the cells. These are called GLUT and seven type of these transpoters are identified (GLUT 1-7). Among these, GLUT-4 is insulin senstive and it is located in cytoplasmic vesicles. It is present in large numbers in muscle and adipose cells...The advantage of GLUT-4 is that it transport glucose at faster rate."

The above quote is from one book on physiology. All the above bold ones indicate that insulin not the only mode of transport of sugar into the target cells. Insulin may be required in case of glucotoxicity or hypeglycemia or when transport of glucose is required at faster rate. Is it not so?
 
A diet with mostly low GI foods may also help reduce the risk of other diseases, such as heart disease and hypertension, although results are not conclusive. Insulin, a hormone needed for carbohydrate metabolism, has a profound effect on the incidence of many diseases. It is thought that high insulin levels are one of many factors in the development of heart disease and hypertension. The consumption of a diet rich high in low GI foods will help to lower raised insulin levels.
http://www.eufic.org/gb/food/pag/food35/food353.htm

Physiotherapist, your post has sprked a thought provokation in me as I quoted above. Does it tell about use of insulin?:). Thanks.

Do tell me about itching effect.
 

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