Have you considered switching to one of those small engined, lighter weight mini-vans that are getting popular with people in the repair business? (Like a Dodge mini-Ram van or an Astrovan, or something?) One of these should net you better gas mileage. You can put racks on the roof to carry ladders, or pipe or 2 x's or plywood/sheetrock.
I'm a housing repair man and I have one of these and they are so much handier than my pickup ever was. I can reach over 1/2 the stuff in the back from my front bucket seat, and what I can't reach I have a sliding door on one side and a hatchback at the rear. No more climbing over tool cases and supplies to get at stuff!
I get about 18+ mpg, but when it was newer it would have got much better.