Questions about Hyperinsulinemia/Diabetes

[Badly Shaved Monkey]

Ewwwwww

Sssshhh! He'll never get a joke like that.

 

[Rolfe]

Sssshhh! He'll never get a joke like that.

No, but the rest of us did. Now, there's an image I could do without....

Rolfe.

 

[Perpetual Notion]

I've been busy for the last couple of weeks and haven't been able to check in. I was going to ask people to catch me up on the last few pages, but, uh, I'm just gonna take a wild guess that things have devolved a bit. I think I need a dynamic beer after that.

 

[Badly Shaved Monkey]

I've been busy for the last couple of weeks and haven't been able to check in. I was going to ask people to catch me up on the last few pages, but, uh, I'm just gonna take a wild guess that things have devolved a bit. I think I need a dynamic beer after that.

Well, one piece of news is that Kumar has finally admitted that insulin resistance is the primary cause of hyperinsulinaemia in Type 2 diabetics, but has receded into gibberish again, so it's hard to tell if it is real progress (after a very long time), a mistake, or a troll letting the mask slip a little.

But, at the risk of repeating myself. He either has to make a coherent response to my last post to his about clarifying his initial ideas or I'll not respond to him again. These petty threats do seem to elicit occasional responses from him, so I'll keep making them until he finally grinds to a complete halt.

 

[Kumar]

Lactate dehydrogenase, also called lactic dehydrogenase, or LDH, is an enzyme found in the cells of many body tissues, including the heart, liver, kidneys, skeletal muscle, brain, red blood cells, and lungs. It is responsible for converting muscle lactic acid into pyruvic acid. It catalyses the interconversion of pyruvate and lactate an essential step in producing cellular energy.LDH is often used as a marker of tissue breakdown/damage. As LDH is abundant in red blood cells, it can function as a marker for hemolysis.

I want to know:-

Can imbalanced Lactic Acid be responsible for tissue breakdown/damage & trigger secretion of LDH enzyme from the cells for the puepose that excess lantic acid, if exposed to tissues, is converted into pyruvate to lessen the toxic effect of LA?

Can there be chronic imbalanced levels of lactic acid in tissues (in ICF or ECF in diabetic patients?

Various disease states make the body tissues more resistant to the actions of insulin. Example include infection (TNFα) and acidosis. Recent research involves the relative roles of adipokines (the cytokines produced by adipose tissue) in modifying insulin resistance.

Insulin resistance and atherosclerosis often appear together. Insulin resistance in these patients can be detected not only by sophisticated tests but by some simple observations of hypertension, hyperglycaemia and dyslipidemia involving small dense low-density lipoprotein (sdLDL) particles.

These patients also have slightly decreased high-density lipoprotein (HDL) levels, impaired fibrinolysis, a hypercoagulable state and increased inflammatory cytokine levels.
LINK.

 

[Kumar]

Well, one piece of news is that Kumar has finally admitted that insulin resistance is the primary cause of hyperinsulinaemia in Type 2 diabetics, but has receded into gibberish again, so it's hard to tell if it is real progress (after a very long time), a mistake, or a troll letting the mask slip a little.

But, at the risk of repeating myself. He either has to make a coherent response to my last post to his about clarifying his initial ideas or I'll not respond to him again. These petty threats do seem to elicit occasional responses from him, so I'll keep making them until he finally grinds to a complete halt.

When you are not "absolute" on "insulin resistance", how can I?

Rest, leave the idiocies & TTTT--which I just "PASS".

May this be a last reply to TTTT/IDT(Idiocy type....).

 

[Donks]

Rest, leave the idiocies & TTTT--which I just "PASS".

Does that mean you will post no more? Cause idiocies and TTTT is all you post.

 

[Kumar]

No, I shall go on doing my duties. But may not read or just ignore TTTT/IDT. You may also practice it with me or commonly, if you feel/find so. Bye to TTTT/IDT.

Diabetic Cardiomyopathy

....If cardiac dysfunction consists predominantly of impaired diastolic function, heart rate control with a beta-blocker or a calcium antagonist is of particular importance. Control of blood glucose should be achieved, with hemoglobin A1c levels of less than 7%. Hyperinsulinemia should be avoided when possible; therefore, insulin-sensitizing agents are preferred over insulin-secretion enhancing agents.

http://www.biomedcentral.com/1092-8464/3/481/abstract

??

 

[Kumar]

Metabolic acidosis
Significant anemia can result in decreased oxygen-carrying capacity less than the needs of the tissue, resulting in increased anaerobic metabolism with production of lactic acid.
LINK.

Lactic Acid Pathway

Metabolic pathway by which glucose is converted to lactic acid (anaerobic respiration):

Oxygen is not used in the process.

NADH + H+ + pyruvic acid lactic acid and NAD.

Produce 2 ATP/glucose molecule.

Some tissues better adapt to anaerobic conditions:

RBCs do not contain mitochondria and only use the lactic acid pathway.

Occurs in skeletal muscles and heart when ratio of oxygen supply to oxygen need falls below critical level.

Skeletal muscle:

Normal daily occurrence.

Does not harm muscle tissue.

Cardiac muscle normally respires aerobically:

Myocardial ischemia occurs under anaerobic conditions.

LINK
. AEROBIC RESPIRATION TAKES PLACE INSIDE THE CELL'S MITOCHONDRIA ("POWER HOUSE").
The side effects of Lactic Acid Fermentation is Muscle Fatigue, Pain, Cramps, and you feel Soreness.
http://www.sirinet.net/~jgjohnso/respiration.html

Importance & relation of LA with diabetes can be useful.

 

[Badly Shaved Monkey]

When you are not "absolute" on "insulin resistance", how can I?

Please stop playing your silly games (why do I even bother to ask?). You wrote the gibberish that I post below.

When all things should have been corrected by following something different and all other things are corrected or remain corrected by following something different except one which was also followed by routine, what a person will think about that routine? If dynamic, will he try to find problems in that routine or not? This much knowlege can make a dynamic person to understand, what is wrong, what is right or what can harm & what not. So just try to find what is wrong in that routine esp. when that couldn't yet be understood completely-- to help him, help you or to all.

Either translate that into something sensible or you'll get no more entertainment out of me. We need a proper summary of your experience with insulin and your other medications and the changes you observed in your blood glucose. Vague rubbish like that quoted above is just pointless obfuscation.

If you don't want help then stop asking for it.

 

[Kumar]

BSM,

A person like me may not beg for help for just appx $10, being the fees of one of best specialist in diabetes...here

Anyway, it may be just for my doubts/dynamism, you or/and humaniity. So I just impress upon you accordingly.

Bye bye TTTT.

 

[Mojo]

Anyway, it may be just for my doubts/dynamism, you or/and humaniity. So I just impress upon you accordingly.

Every time Kumar types one of these sentences, somewhere a good grammar fairy dies...

 

[Kumar]

BSM, One can listen/take care/bother of that who have much credit balance in his account of contributions to him. So it is better to first maintain the credit balance.

I may take care for some TTTT for relaxation purpose after serious/prolonged discussions with whom, who will have credit balances of contributuions with me. Otherwise WHY I will bother.

To add to credit balance:-

Can imbalanced Lactic Acid be responsible for tissue breakdown/damage & trigger secretion of LDH enzyme from the cells for the puepose that excess lantic acid, if exposed to tissues, is converted into pyruvate to lessen the toxic effect of LA?

Can there be chronic imbalanced levels of lactic acid or acidosis in tissues (in ICF or ECF) in diabetic patients, which probably may discourage insulin aided more glucose into the cells or cause IR?

 

[Badly Shaved Monkey]

BSM, One can listen/take care/bother of that who have much credit balance in his account of contributions to him. So it is better to first maintain the credit balance.

I may take care for some TTTT for relaxation purpose after serious/prolonged discussions with whom, who will have credit balances of contributuions with me. Otherwise WHY I will bother.

To add to credit balance:-

No. I have no need of a credit balance with you. You are asking us questions. It's your meter that is far into the red zone.

Unless you ask sensible questions you will not obtain sensible answers.

To ask a sensible question you need to explain your prior assumptions properly. So, once again, I ask that you translate the following;

When all things should have been corrected by following something different and all other things are corrected or remain corrected by following something different except one which was also followed by routine, what a person will think about that routine? If dynamic, will he try to find problems in that routine or not? This much knowlege can make a dynamic person to understand, what is wrong, what is right or what can harm & what not. So just try to find what is wrong in that routine esp. when that couldn't yet be understood completely-- to help him, help you or to all.

 

[Kumar]

There is a definite limit to anerobic respiration because of the lactic acid. The acid is what makes your muscles hurt. Lactic acid builds up in the muscle tissue and causes the fatigue and soreness you feel in your exercising muscles.
LINK.

Can acid be a cause to muscle damage & release of cardiac & oher enzymes? Can modern mental stresses,lifestyle & environment add some acid in us? Whether tiredness, fatigue, soreness/pain in muscles are related to LA builtup in muscles?

 

[MRC_Hans]

Can acid be a cause to muscle damage & release of cardiac & oher enzymes? Can modern mental stresses,lifestyle & environment add some acid in us? Whether tiredness, fatigue, soreness/pain in muscles are related to LA builtup in muscles?

Pain in miscles can be an aftereffect of acid build-up, but the acid (lactic acid) itself will go away after a relatively short time. Only if muscles are actually cramped will a lactic acid buildup stay for some period.

Lactic acid buildup happens when your body does not get enough oxygen, either because of heavy exercise or respiratory problems. In case of respiratory problems, the condition can be prolonged, but you will be quite sick.

(The Kumar knee-jerk reaction to anything at all: Can modern lifestyle & environment cause ... whatever )

At least we taught him to spell "modern", that alone took about a year, but don't say all is hopeless .

Hans

 

[Kumar]

Pain in miscles can be an aftereffect of acid build-up, but the acid (lactic acid) itself will go away after a relatively short time. Only if muscles are actually cramped will a lactic acid buildup stay for some period.

Even for shorttime, acidic effect may cause muscle damage. Can release of LDH & other enzymes be due to some excess of lactic acid?

Lactic acid buildup happens when your body does not get enough oxygen, either because of heavy exercise or respiratory problems. In case of respiratory problems, the condition can be prolonged, but you will be quite sick.

Yes, I am thinking if. "not getting enough Oxygen" may be related to many modern problems. Can excess modern mental stresses is alike heavy excercise & need more O2 to overcome it?

(The Kumar knee-jerk reaction to anything at all: Can modern lifestyle & environment cause ... whatever )

At least we taught him to spell "modern", that alone took about a year, but don't say all is hopeless .

Hans

Yes, two spelling correction is at your and Mojo's credit--modern & different. Many other things can also be there to add.

 

[Mojo]

Pain in miscles can be an aftereffect of acid build-up, but the acid (lactic acid) itself will go away after a relatively short time. Only if muscles are actually cramped will a lactic acid buildup stay for some period.

Isn't cramp caused by lack of sodium or calcium ions?

 

[Mojo]

Can excess modern mental stresses is alike heavy excercise & need more O2 to overcome it?

No. The brain uses pretty much the same amount of energy, and hence the same amount of oxygen, whatever it's doing.

This is why physical exercise will help someone lose weight, but mental activity won't.

 

[MRC_Hans]

Lactic acid buildup happens when your body does not get enough oxygen, either because of heavy exercise or respiratory problems. In case of respiratory problems, the condition can be prolonged, but you will be quite sick.

Yes, I am thinking if. "not getting enough Oxygen" may be related to many modern problems. Can excess modern mental stresses is alike heavy excercise & need more O2 to overcome it?

See? Kumar in a nutshell:

Kumar: Can modern stresses (etc.) give build-up of lactic acid?

Hans: No only heavy exercise and serious respiratory problems.

Kumar: Yes, can modern stresses give build-up of lactic acid?

Now, as it takes a year to make Kumar correct a simple spelling mistake, we can infer that actually teaching him even a little real science is multi-decade project .

Kumar, whenever you are prepared to actually read an answer to one of your questions, give me a call, OK?

Hans