Can't you think anything about prime resonaning for getting IR? If it is not known perfectly, how can you say any presented theory thought can't be right? Anyway pls try to link the possibility of prime contributing factor anything out of following aspects with getting IR:-
Glucose:- excess-- ingestion, digestion, absorption or lesser cellular taking, lesser cellular metabolism, , lesser loss in urine or glucose imbalances(more at one place & lesser at other place still keeping total normal in body), real excess or real deficient.
Insulin:- Its persistent Excess, low or imbalanced levels. Its quality differcences. It unable to unlock cell membrane doors, it do something which causes lipids or phospholipid cellular membrane to cause IR.
Digestive:- acid, base & water(mucus) imbalances, digestion & absorption imbalances.
Cells:- cellular metabolism & respiration impaired due to excess of glucose, lipids or insulin, receptors regulations--temporary or permanent. Lactic acidosis.
Obesity:- Limit of glucose & fats, blood lipids levels, cellular lipid levels, lipids in cellular membrane, liver lipids, fatty fegenaration, respiration & oxidation effected due to excess fats...etc.
Genetic/Inharent/Aquired predispositions--phenotype or genotype-- what these reasons primarily effects--digestive, hormonal or cellular imbalances or defects.
Mental: stresses, tensions, neuro-transmissions defects, mis-impression of previously persistent confused signals(mental stresses may be confused for physical stresses).
Infectious:-Any infection.
Others: Medications oriented, modern lifestyle & environmenrt-you can think more.
We may have to found some prime reasonings. If we couldn't then, let the show go on, anytype as it may add something.
Btw, other question; Can more lactic acid levels cause more LDH/LDH isoenzimes secretions? Can some lactic acidosis be a chronic condition? Do lesser O2 levels or RBCs defects encourage it? Pls tell me as much as you can tell about it?
Can IR be possible due to intracellular causes instead of insulin can't unlock cells doors? Can it be due to some IC reasons after Acetyl CO A is formed? One link suggest some intracellular possibilities which I recently given?
What are the bye-products of diabetes medicines & Insulin? Are these sulphur & acids?