PixyMisa
Persnickety Insect
It's interesting that of that list of 25 major unanswered questions, 15 are in biology, 2 in applied science, 2 in earth sciences, one in chemistry, and just 3 in physics. One is just a general knowledge question ("Are we alone in the Universe? I don't know, I'll go look.") And the last might be physics or mathematics or engineering, but you can't tell because they never phrase the question clearly.