marting
Illuminator
- Joined
- Sep 18, 2003
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From Eric Topol's substack:
Shane Crotty: A Landmark Study on Upper Airway Mucosal Immunity
https://erictopol.substack.com/p/shane-crotty-a-landmark-study-on
Shane Crotty: A Landmark Study on Upper Airway Mucosal Immunity
https://erictopol.substack.com/p/shane-crotty-a-landmark-study-on
This is the first time a Ground Truths podcast is being posted simultaneous with a new publication, this one in Nature, by Professor Shane Crotty and his colleagues at La Jolla Institute for Immunology.
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Today’s paper in Nature is indeed a landmark contribution doing something that hasn’t been done before—to understand the underpinnings of mucosal immunity of the upper airway. 100 participants had monthly nasal and nasopharyngeal swabs throughout the pandemic. With a median of >100,000 cells per swab recovered , they undertook single-cell sequencing and full characterization of the cells (B, T, C4+, CD8+, tissue-resident cells, follicular T helper cells, germinal centers, etc) to determine optimal immune protection of the upper airway, the effect of infections by different variants, breakthrough infections, vaccination, and age.