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Cont: The One Covid-19 Science and Medicine Thread Part 5

First hand covid report.

My boy, who wears an N95 mask everywhere, managed to pick up a dose of covid on the weekend. Very mild symptoms so far - he's fully vaccinated, with last vaccine in June. We're hoping it doesn't **** with his kidneys again, but you can't live in a bubble and covid is just a fact of life now.

I imagine I'll test positive, along with the rest of the household - within the next 24 hours. I already have Paxlovid on order for when that happens.
 
First hand covid report.

My boy, who wears an N95 mask everywhere, managed to pick up a dose of covid on the weekend. Very mild symptoms so far - he's fully vaccinated, with last vaccine in June. We're hoping it doesn't **** with his kidneys again, but you can't live in a bubble and covid is just a fact of life now.

I imagine I'll test positive, along with the rest of the household - within the next 24 hours. I already have Paxlovid on order for when that happens.


Not necessarily.
When my daughter got it, I didn't, and we are living in a 50 square meter flat together.
And I haven't even been overly cautious, because I thought I'd get it anyway....

Good luck for your son!
 
Any updates?
I ask because I think you mentioned that he has a problem with his immune system or some related illness....
If I misremember, just ignore......
 
First hand covid report.

My boy, who wears an N95 mask everywhere, managed to pick up a dose of covid on the weekend. Very mild symptoms so far - he's fully vaccinated, with last vaccine in June. We're hoping it doesn't **** with his kidneys again, but you can't live in a bubble and covid is just a fact of life now.

I imagine I'll test positive, along with the rest of the household - within the next 24 hours. I already have Paxlovid on order for when that happens.


Oh, that's a shame. Given his condition, I mean, that you've talked about earlier in the other thread.

But still, as you say, his symptoms seem mild. Hope they stay that way, and he gets fully well soon!
 
Any updates?
I ask because I think you mentioned that he has a problem with his immune system or some related illness....
If I misremember, just ignore......

No, your memory is spot on - he has a thing called IgA nephropathy, and the really bad part is, infections of any kind can cause his kidneys to bleed, which is not a good thing. His immune system goes into overdrive and clogs up his kidneys. First time he had covid he was pissing tomato sauce and spent a couple of days in hospital.

Oh, that's a shame. Given his condition, I mean, that you've talked about earlier in the other thread.

But still, as you say, his symptoms seem mild. Hope they stay that way, and he gets fully well soon!

Thanks to the pair of you - it's still very mild so far. Fever of 38C for one day and a mild cough. No kidney issues so far, so we have fingers crossed hard.

Quite unbelievable he caught it. We went to a fairly corded museum show but he wasn't cheek-to-cheek with other people and wears an N95 mask and still managed to catch it, but only him.
 
In a completely different line of infection, our son-in-law now also has covid.

Kind of ironic to me that when a couple of people were screeching about waves of infection here I didn't know anyone who caught it, now it's all but disappeared from view we have 3 in the family, no doubt soon to rise to 6.

It seems to me that my premise of repeated vaccines and infections creating much more robust immune systems against covid is quite likely true.

Both my boy and son-in-law had quite severe doses the first time and now, they're not very sick at all and infinitely less crook than if they had 'flu.

This is the new normal.
 
Ok, having now had the benefit of a personal look at covid c.2014, I'm fairly sure my take on the disease is pretty damned close to the truth.

I had zero symptoms, our boy has come right after 4 days of very mild symptoms, and son-in-law is almost past his mild symptoms. Neither my wife, daughter, or older son contracted covid, despite living in the same house and space as positive cases.

We have all had all the vaccinations and have all had covid once or twice previously.

It seems extremely likely that the combination of vaccines and infections are indeed granting us a strong level of immunity against the disease, which is now far milder than even a common rhinovirus/cold infection.

If covid is killing people in 2024, aside from very rare instances, it is killing people with days or weeks to live anyway. I've talked to doctors at our GP clinic, nurses in the pediatric ward and lots of people around the traps, and nobody is suffering serious effects from covid. There's plenty of it still around, but there seems no question it is waning, despite the cutely-named variants.

That's not to say that the disease can't mutate again and become more serious, but given the mutations have skewed to infectiousness and not seriousness, I think that's unlikely.

I suspect that inside a couple of years even vaccines won't be necessary and the disease will become a distant memory, because the wide majority of people won't even know they've got it. In the meantime, get your 6-12 monthly vaccines and ignore it.
 
Whereas over here severity and hospitalisations are increasing rapidly: https://www.msn.com/en-gb/health/ot...e-people-with-symptoms-to-isolate/ar-AA1s2kCb (Sorry for the MSN link)

Oh, terrifying!

Except...

Those aged 85 years and over had the highest hospital admission rate, which increased to 52.48 per 100,000 compared with 40.39 in the previous week

Tragic indeed. Very old people are getting sick. Some of them will probably die.

Severity increasing?

Current information doesn’t suggest we should be more concerned about this variant but we are monitoring this closely. The most important thing to do is to get your vaccination as soon as possible if you’re eligible.

Nope.

I'm sure people who aren't keeping up to date with vaccines are getting worse symptoms than those who do. I can't be too concerned about that, but it's pretty clear it's not more severe.

XEC probably needs a cooler name - are there any left we haven't used?
 
MedPageToday reported, "The inability of COVID vaccines to reach the long-lived plasma cell compartment in the bone marrow may explain their waning protection compared with vaccines for influenza or tetanus, according to a recent study published in Nature Medicine." One of the authors was interviewed and discusses some of the possible reasons for this. "So the spike protein -- and we wrote about this in the discussion and you can read more about it in the paper -- is that the spike protein is very far apart. Normally a lot of viruses have repetitive protein epitopes on their surface. They're really close together, so they like to cross link that B-cell receptor that's coming across."
 
MedPageToday reported, "The inability of COVID vaccines to reach the long-lived plasma cell compartment in the bone marrow may explain their waning protection compared with vaccines for influenza or tetanus, according to a recent study published in Nature Medicine." One of the authors was interviewed and discusses some of the possible reasons for this. "So the spike protein -- and we wrote about this in the discussion and you can read more about it in the paper -- is that the spike protein is very far apart. Normally a lot of viruses have repetitive protein epitopes on their surface. They're really close together, so they like to cross link that B-cell receptor that's coming across."
Interesting article. If the problem is the mRNA vaccines - "is it something unique to spike or SARS-CoV-2 or is it something unique to the mRNA platform? (...) is it something with the mRNA platform itself" - one would expect Novavax to do better in this respect. The Cuban vaccine Abdala targeting the receptor-binding domain (RBD) actually does seem to induce longer-lasting immunity. It also makes use of an adjuvant (tetanus), an aspect of vaccine efficacy mentioned in the MedPage transcript, so I find it strange that the world of medical science in the West hasn't paid more attention to this.
 
Ok, having now had the benefit of a personal look at covid c.2014, I'm fairly sure my take on the disease is pretty damned close to the truth.
'I've just been ill, so now I know everything there is to know about this disease.'
I had zero symptoms, our boy has come right after 4 days of very mild symptoms, and son-in-law is almost past his mild symptoms. Neither my wife, daughter, or older son contracted covid, despite living in the same house and space as positive cases.
'I have a sample size of three, which is more than enough to pretend that I know everything that's worth knowing.'
We have all had all the vaccinations and have all had covid once or twice previously.

It seems extremely likely that the combination of vaccines and infections are indeed granting us a strong level of immunity against the disease, which is now far milder than even a common rhinovirus/cold infection.
'The disease is now much milder than the common cold because we had it and we didn't go to the hospital, so something must be seriously wrong with people who are hospitalized with it. It can't possibly be because of the disease when we didn't notice any serious problems.
If covid is killing people in 2024, aside from very rare instances, it is killing people with days or weeks to live anyway. I've talked to doctors at our GP clinic, nurses in the pediatric ward and lots of people around the traps, and nobody is suffering serious effects from covid. There's plenty of it still around, but there seems no question it is waning, despite the cutely-named variants.
'I know that this disease can't possibly be as serious as some people claim because that's what I have been claiming for a couple of years now. My predictions may have been entirely wrong, but I'm right anyway. I've talked to people (an argument I've borrowed from Donald Trump) who told me that I'm right, so it's obvious that I am right, and the (at this point often hard to come by) facts and numbers are irrelevant.
I don't need them. My anecdotal evidence should suffice to convince you that I'm right.'

That's not to say that the disease can't mutate again and become more serious, but given the mutations have skewed to infectiousness and not seriousness, I think that's unlikely.

I suspect that inside a couple of years even vaccines won't be necessary and the disease will become a distant memory, because the wide majority of people won't even know they've got it. In the meantime, get your 6-12 monthly vaccines and ignore it.
'So far, my predictions may have been entirely wrong, but I nevertheless expect you to take me seriously when I tell you what I suspect, i.e. approximately the same thing I suspected two years ago.'
- - - -

Correct me if I'm wrong, but isn't this supposed to be the Science, Mathematics, Medicine and Technology subforurm?
Why isn't something like this about somebody's personal experiences, health issues, suspicions and anecdotes posted in Forum Community instead?
 
Warum jede Corona-Infektion schlecht für uns ist (Brisant, Nov 21, 2024)
Schon wieder Corona? Ach egal, fühlt sich ja nur an wie eine Grippe - und nach einigen Tagen ist man wieder fit. So hört man es gerade überall. Tatsächlich sind die aktuellen Corona-Varianten zwar hochansteckend, führen aber nicht öfter als bisher zu schweren Verläufen. Alles beherrschbar also?

MIT JEDER CORONA-INFEKTION STEIGT DAS LONG-COVID-RISIKO​

Der sorglose Umgang mit Corona kann tückisch sein, denn das Risiko, an Long Covid zu erkranken, ist mit jeder Corona-Infektion da. "Neuere Untersuchungen von Versichertendaten aus den USA weisen außerdem darauf hin, dass das Risiko für Langzeitfolgen steigt, wenn man sich mehrmals mit dem Coronavirus ansteckt", schreibt das Bundesministerium für Gesundheit (BMG) auf seiner Homepage.

My translation:
The Reason Why Every COVID-19 Infection Is Bad for Us
Got Covid again? Never mind, it just feels like the flu - and after a couple of days you're well again. This is what you currently hear everywhere.
The current COVID-19 variants are actually very infectious, but they don't lead to worse outcomes than before. So everything's under control?

THE LONG-COVID RISK RISES WITH EVERY NEW COVID INFECTION​

The carefree handling of Covid can be treacherous because the risk of getting Long Covid is there with every new infection. Recent studies of data from health insured people in the USA indicate that the risk of sequelae grows if you are infected with SARS-CoV-2 again and again," says the Federal Ministry of Health (BMG) on its website.
- - - -

The link is to a pretty good article in German.
 
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Covid-19 may lead to longest period of peacetime excess mortality, says new Swiss Re report (Swiss Re, Sep 16, 2024)

  • Key driver of excess mortality is the lingering impact of COVID-19; both as a direct cause of death, and as a contributor to cardiovascular mortality
Paul Murray, CEO L&H Reinsurance at Swiss Re says: "COVID-19 is far from over. The US reported an average of 1500 COVID-19 deaths a week for 2023 – comparable to fentanyl or firearm deaths. If this continues, our analysis suggests a potential scenario of elevated excess mortality extending over the next decade. However, excess mortality can return to pre-pandemic levels much sooner. The first step is to get COVID under control, with measures such as vaccinations for the vulnerable. Over the longer term, medical advancements, a return to regular healthcare services, and the adoption of healthier lifestyle choices will be key."

Excess mortality is a measure of the number of deaths above an expected level in a given population. Typically, all-cause excess mortality should be around zero, as the major causes of death remain relatively stable over the long-term baseline assumption.

Fluctuations in excess mortality tend to be short-term, reflecting developments such as a large-scale medical breakthrough or the negative impact of a large epidemic. However, as society absorbs these events, excess mortality should revert to the baseline.

With COVID-19 this has not been the case and all-cause excess mortality is still above the pre-pandemic baseline. In 2021, excess mortality spiked to 23% above the 2019 baseline in the US, and 11% in the UK. As Swiss Re Institute's report estimates, in 2023, it remained significantly elevated in the range of 3–7% for the US, and 5–8% for the UK.

It is worth noting that the rise in excess mortality is actually accompanied by the large-scale medical breakthrough of products like Ozempic and Wegovy that lower the mortality of the user group.
 
Interesting paper on the impact of vaccinations on long covid.

The effect of pre-COVID and post-COVID vaccination on long COVID: a systematic review and meta-analysis

Main finding was about a 24% risk reduction in long covid after infection when vaxxed (2 shots) pre-infection. Some indication that vax after infection also provided some benefit but small numbers produced high p values.

There was a larger drop after three shots but they had very small numbers so not significant with really large CIs.

I looked to see what info they had on time between vax, infection, and long covid was. The studies they reviewed had little time info so they were unable to study this. Also, as time goes on an increasing numbers would have had prior asymptomatic infections. Unclear how that might have affected the results but it detracts somewhat from the study's results.

One of the good aspects was they broke down symptom reduction by type. Pretty big effects on loss of smell, a clear, unambiguous symptom.
 
No, loss of smell is by no means an unambiguous symptom. I am not sure that there are any unambiguous symptoms of Long Covid apart from persistent infection, which makes it very difficult to determine if symptoms in individual cases are the result of a COVID-19 infection or something else once the infection is entirely gone.
Only population studies make the long-term damage caused by COVID-19 fairly unambiguous. The disproportionate rise in the number of pediatric diabetes type 1 cases in previously infected children in comparison to uninfected children is one example.
And a major difficulty when conducting population studies which researchers have mentioned recently is finding enough uninfected people for control groups.
 
Changes in memory and cognition during the SARS-CoV-2 human challenge study

This is from a challenge study where 34 young people were infected with the wild type SARS-CoV-2. 17 developed mild Covid-19 and one had no symptoms but was PCR positive. While cognitive deficit measures were significant with low p values, no subject reported perceived cognitive issues. Still rather disturbing.

https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00421-8/fulltext

There have been several articles and studies in the past couple of months about COVID-19's impact on the brain:

Cognitive deficits after COVID-19 associated with brain injury biomarkers and volume loss (PubMed, Nov 25, 2024)

Article: New research shows younger and middle-aged adults have worse long COVID symptoms than older adults (Northwestern Medicine, Nov 22, 2024)
Study: Neurologic Manifestations of Long Covid Disproportionately Affect Young and Middle-Aged Adults (Annals of Neurology, Nov 22, 2024)

Brain-wide alterations revealed by spatial transcriptomics and proteomics in COVID-19 infection (Nature Aging, Nov 14, 2024)

The Impact of Covid on Your Brain: What We Know (Daily Galaxy, Nov 19, 2024)

Long Coronavirus Disease and the Brain: Molecular Neuroimaging Insights into Neurological and Psychiatric Sequelae (PubMed, Oct 30, 2024)

Unravelling Covid's Pernicious Role in Brain Fog and Clotting (Bloomberg, Nov 4, 2024)

COVID survivors may develop dementia - they are also at higher risk of depression, anxiety and insomnia (Nature, Oct 21, 2024)

Increased post-COVID-19 behavioral, emotional and social problems in Taiwanese children (ScienceDirect, Oct 20, 2024)

We Just Got More Evidence That Long COVID Is a Brain Injury (ScienceAlert, Oct 17, 2024)

COVID-19 Damages a Major Brain "Control Center", Ultra-Powerful MRI Scans Reveal (IFL Science, Oct 8, 2024)
Severe Covid infections can inflame brain's 'control center', research says (TheGuardian, Oct 8, 2024)

Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction (Nature, Sep 23, 2024)
(See also short Eric Topol X thread, Sep 25, 2024)

Scientists discover troubling brain changes in COVID-19 patients who lost sense of smell (PsyPost, Sep 25, 2024)

COVID-19 causes lasting cognitive impairment tied to brain injury markers (News Medical, Sep 26, 2024)

Study sheds new light on severe COVID¨s long-term impacts (CIDRAP, Sep 24, 2024)
 
Long Covid
There ain't no cure for ...

A systematic review of 24 randomized trials for #LongCovidhttps://bmj.com/content/387/bmj-2024-081318 open-access
@bmj_latest

No drug, diet, or device intervention has supportive evidence for efficacy. CBT, rehab provided some relief of symptoms (moderate certainty). We're still in desperate need for a validated treatment!
Eric Topol on X, Nov 28, 2024

Interventions for the management of long covid (post-covid condition): living systematic review (BMJ, Nov 27, 2024)

Four years on from the pandemic and long Covid's inequalities have only worsened (Telegraph, Nov 27, 2024)
 
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There have been several articles and studies in the past couple of months about COVID-19's impact on the brain:

Scientists discover troubling brain changes in COVID-19 patients who lost sense of smell (PsyPost, Sep 25, 2024)
I found this in the article rather interesting:

Interestingly, these brain changes were less pronounced in patients with more severe respiratory symptoms, such as those requiring hospitalization, suggesting that anosmia might be a more reliable indicator of neurological involvement than respiratory symptom severity.

“What surprised us the most was how consistent the findings were in patients with anosmia compared to other patients, regardless of the severity of their respiratory symptoms,” Billeke said. “These individuals exhibited detectable alterations at the behavioral level and in brain function and structure, affecting white matter and gray matter.”
 

Increased Risk of Alzheimer's Disease Post COVID-19, Danish Researcher Suggests (Alzheimer's Research UK, June 24, 2024)
An announcement from the conference reports that researchers looked at the health records of people in Denmark. They found that those who had tested positive for COVID-19 were at an increased risk of being diagnosed with Alzheimer’s disease, Parkinson’s disease, and ischaemic stroke.
COVID-19 is associated with new symptoms of multiple sclerosis that are prevented by disease modifying therapies (NIH, May 5, 2021)
Association between blood pressure and COVID-19 severity (Hypertension Research/Nature, Dec 25, 2023)
Hypertension was reported to be more frequent as a sequela of COVID-19 than in non-COVID-19 patients, and COVID-19 was considered to be a risk factor for the development of hypertension.
 
I found this in the article rather interesting:

Interestingly, these brain changes were less pronounced in patients with more severe respiratory symptoms, such as those requiring hospitalization, suggesting that anosmia might be a more reliable indicator of neurological involvement than respiratory symptom severity.

“What surprised us the most was how consistent the findings were in patients with anosmia compared to other patients, regardless of the severity of their respiratory symptoms,” Billeke said. “These individuals exhibited detectable alterations at the behavioral level and in brain function and structure, affecting white matter and gray matter.”
That's worrying as that's my "long covid" symptom, my sense of smell has come back quite a bit but it is still limited as to what it used to be. I can hardly smell citrus scents these days and just about can smell "pine" again.
 
That your sense of smell is returning sounds like a good sign, but I haven't seen it mentioned in comparison to people with no improvement of their anosmia in this context.
Have you noticed any of the behavioral changes mentioned in the article?
In behavioral tests, participants with a history of anosmia displayed more impulsive decision-making compared to those who did not lose their sense of smell. These individuals tended to change their choices more rapidly after receiving negative feedback, particularly in tasks requiring them to learn and adapt to changing probabilities of rewards. While this impulsivity led to higher earnings in decision-making tasks that involved rapidly shifting conditions, it also highlighted an alteration in how their brains processed rewards and risks.
In early 2021, when young and middle-aged people had to wait till June-July to get their Pfizer-BioNTech or Moderna shots, some people working in the culinary industry chose to get the AstraZeneca or J&J vaccines instead, specifically to avoid getting anosmia. AZ and J&J were readily available unlike the two mRNA vaccines.

The "impulsivity" in the anosmia cohort and the "alteration in how their brains processed rewards and risks" is ominous.
During COVID-19*, Road Fatalities Increased and Transit Ridership Dipped (Jan 25, 2022)
Empty streets, highways, and transit systems were a visible effect of the pandemic on our daily lives. Despite how quiet our roads got at the onset of the pandemic, they also became more dangerous.
Today’s WatchBlog post looks at recent data on traffic safety, and our recent reports on the pandemic’s effects on public transportation and how the federal government has responded to these impacts.
After a long period of decline, traffic fatalities have increased even as many switched to working from home
I wonder if pilots are routinely examined for impulsive decision-making. And presidents! But Trump never responded well to negative feedback.

* 'during COVID-19'!!! In January 2021!!!
 
That's worrying as that's my "long covid" symptom, my sense of smell has come back quite a bit but it is still limited as to what it used to be. I can hardly smell citrus scents these days and just about can smell "pine" again.
Ran across this long covid blog out of Yale.

Patricia H.* knew that something was wrong. “One night I sat down with my boyfriend to eat dinner and thought, ‘Did I not spice this chicken? Because it has no flavor.’” She then realized that she couldn’t smell her dinner either. “My boyfriend looked at me and said, ‘You have COVID!’” He was right. It was March 2020. Fortunately, Patricia didn’t have any other symptoms. But more than four years later, she still hasn’t regained her sense of taste and smell.

She’s certainly not alone. An estimated 60% of patients infected in 2021 with SARS-Co-V2, the virus that causes COVID, lost some ability to taste or smell, according to research published in 2023. Even though such changes are usually transient, the research also found that one-quarter of those patients didn’t experience a full recovery and were left with a diminished sense of smell.

Nice piece with links to support groups. It's specific to anosmia in long covid.
 
New study:
Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 (Cell Host & Microbe, Nov 29, 2024)
SARS-CoV-2 infection is associated with long-lasting neurological symptoms, although the underlying mechanisms remain unclear. Using optical clearing and imaging, we observed the accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients, persisting long after viral clearance. Further, biomarkers of neurodegeneration were elevated in the cerebrospinal fluid from long COVID patients, and proteomic analysis of human skull, meninges, and brain samples revealed dysregulated inflammatory pathways and neurodegeneration-associated changes. Similar distribution patterns of the spike protein were observed in the SARS-CoV-2-infected mice. Injection of spike protein alone was sufficient to induce neuroinflammation, proteome changes in the skull-meninges-brain axis, anxiety-like behavior, and exacerbated outcomes in mice models of stroke and traumatic brain injury. Vaccination reduced but did not eliminate spike protein accumulation after infection in mice. Our findings suggest persistent spike protein at the brain borders may contribute to lasting neurological sequelae of COVID-19.
 
ZDoggMD finally gets Covid after 4.5 years.

I like this video because it gives the doctor's perspective on the symptoms and how it differs from other illnesses. Interesting fellow because he is friends with both Dr. Paul Offit and Dr. Vinay Prasad. Very reasonable doc though I'm not into the mediation stuff that seems to fascinate him.

His daughter got Covid at camp a few days earlier, came home, then he got it. She tested positive with a rapid test. Initial rapid test for ZDoggMD was totally negative even though he had strong symptoms then strong positive the next day. Has some distortion in sense of smell/taste. Typical range of symptoms. Is recovering. Says he will report on any long term issues.

His wife hasn't gotten Covid and still is negative. She also had current boosters. ZDoggMD has not had recent boosters.

The most recent article about ZDoggMD (Zubin Damania) at Science-Based Medicine:
ZDoggMD on RFK Jr.'s Rise: "I'm Talking about Like These Science Based Medicine Guys" (Science-Based Medicine, Nov 29, 2024)

ZDoggMD was also mentioned in an earlier post-election article:
If You Sanewashed RFK Jr., or if You Sanewashed Doctors Who Did, You Own the Next 4 Years (Science-Based Medicine, Nov 15, 2024)

The first article has a link to a very good Mehdi Hasan video:
'Kids died.' The story of RFK Jr., anti-vaxxers, and a measles outbreak: Mehdi's deep dive (MSNBC, July 6, 2023 - 9:33 min.)
Mehdi Hasan also had many good videos about the SARS-CoV-2 pandemic. He is sadly missed.
 
Frontiers published a set of 5 articles on long covid.

Unraveling the long-term effects of COVID-19​


Variety of topics from belly fat to impact on cancer and brain aging. I think the title is wrong. Not much unraveling but still interesting.
 
No, loss of smell is by no means an unambiguous symptom. I am not sure that there are any unambiguous symptoms of Long Covid apart from persistent infection, which makes it very difficult to determine if symptoms in individual cases are the result of a COVID-19 infection or something else once the infection is entirely gone.
Only population studies make the long-term damage caused by COVID-19 fairly unambiguous. The disproportionate rise in the number of pediatric diabetes type 1 cases in previously infected children in comparison to uninfected children is one example.
And a major difficulty when conducting population studies which researchers have mentioned recently is finding enough uninfected people for control groups.
Huh? Last I read there was uncertainty whether Covid-19 even causes Type One Diabetes let along a component of long covid.
 
When and where was the last time you read about this? I assume you know there's a lot of disinformation out there.
It's not an entirely new insight:

Risk for Newly Diagnosed Diabetes >30 Days After SARS-CoV-2 Infection Among Persons Aged <18 Years — United States, March 1, 2020–June 28, 2021 (CDC, Jan 14, 2022)

Persons aged <18 years with COVID-19 were more likely to receive a new diabetes diagnosis >30 days after infection than were those without COVID-19 and those with prepandemic acute respiratory infections. Non–SARS-CoV-2 respiratory infection was not associated with an increased risk for diabetes.

Diabetes type 2:
Article: COVID Greatly Increases Diabetes Risk in Kids and Teens (WebMD, Oct 15, 2024)
Study: SARS-CoV-2 Infection and New-Onset Type 2 Diabetes among Pediatric Patients, 2020 to 2022 (JAMA, Oct 14, 2024)

Diabetes type 1:
Article: COVID-19 infection associated with type 1 diabetes in kids (CIDRAP, May 23, 2023)
Study: Type 1 Diabetes Incidence and Risk in Children with a Diagnosis of COVID-19 (JAMA, May 22, 2023)
Article: Covid pandemic linked to surge in child and teen diabetes (BBC, June 30, 2023)
Study:
Incidence of Diabetes in Children and Adolescents during the COVID-19 Pandemic: A Systematic Review and Meta-Analysis (NIH/PMC, June 30, 2023)

They have even noticed a connection in Sweden:
Koppling mellan virus och barndiabetes stärks (Forskning.se, )
Rapporten om Typ 1-diabetes (Barndiabetesfonden 2024) 62% increase of 0-5-year-olds in Sweden with Type1-diabetes.
Tredubbling av typ 1-diabetes hos barn sedan 2018 - oklart varför (SverigesRadio.se, Nov 14, 2024) Cases have tripled since 2018
Bebisar ska skyddas mot diabetes - genom att vaccineras mot covid-19 (TV4.se, June 18, 2024)

Post-C19 diabetes type 1 and 2 In adults:
Incidence of diabetes after SARS-CoV-2 infection in England and the implications of COVID-19 vaccination: a retrospective cohort study of 16 million people (The Lancet, Aug 2024)
 
When and where was the last time you read about this? I assume you know there's a lot of disinformation out there.
It's not an entirely new insight:
Actually, the following paper you linked to was what I had last read!

The problem is that sufficiently powered studies haven't found a link for type 1 diabetes. Here's a quote from the paper:

At least 700 million people worldwide have been infected with SARS-CoV-2.1,2 Reports of an excess risk of diabetes after COVID-193–9 therefore have alarming public health implications. A 30–50% excess incidence of type 2 diabetes after SARS-CoV-2 infection has been reported.3–6,9,10 by contrast, the only three studies that were sufficiently powered for such analyses found no association between type 1 diabetes and SARS-CoV-2
And we were both talking about type 1 diabetes.

Here's another paper:

CONCLUSIONS
Our data do not support that SARS-CoV-2 infection is associated with type 1 diabetes or that type 1 diabetes should be a special focus after a SARS-CoV-2 infection in children.

There does seem to be more evidence that type 2 diabetes increases in children after Covid-19 infection. However, the incidence is low (.1 to .2%) and there is also the unexplained near doubling here in the decade prior to 2020. Anosmia, as a symptom, is running over 50%. Seems a more useful marker. Also, it concerns me more since it may well be an indicator of cognitive effects.
 
The unexplained near doubling in the decade prior to 2020 is interesting, but it does not make the 62% increase since 2018 any less dramatic even that is obviously your reason for mentioning it. The rise has actually accelerated since 2020: the Swedish report, p. 23, see curve!
Fler små barn får typ 1-diabetes tidigt
Insjuknande i typ 1-diabetes sammanfaller ofta med en tillväxtfas hos barn eftersom hormoner gör att blodsockret stiger. Därför får många barn typ 1-diabetes i början av puberteten. De senare åren har antalet barn som debuterar innan de fyllt fem år stigit kraftigt. Från en långsam ökning de senaste årtiondena har kurvan vikit kraftigt uppåt de senaste åren. 2018 vårdades 284 barn under fem år för typ 1-diabetes. 2022 var de 460. Det innebär en ökning på 62 procent.
More young children get diabetes type 1 early
Falling ill with diabetes type 1 often coincides with growth spurs in children since hormones make the blood sugar level rise. That is why many children get diabetes type 1 in early puberty. In recent years, the number of children younger than five getting diabetes have increased significantly. From a slow increase in recent decades, the curve has risen rapidly in recent years. In 2018, 284 children were hospitalized with diabetes type 1. In 2022, there were 460, an increase of 62 percent.

And why do you ignore the actual findings of the recent British study of 16 million people in The Lancet? You're in bad faith when you present a quotation from the study mentioning the results of earlier studies!!!
This is what the study says in the paragraph "Added value of this study":
This study—which, to our knowledge, isthe largest to date to address the association between COVID-19 and different subtypes of diabetes and the role of COVID-19 vaccination—analysed linked primary and secondary care health records with SARS-CoV-2 testing and COVID-19 vaccination data for 16 million people living in England. This analysis enabled us to compare the increase in incident diabetes diagnosis after COVID-19 diagnosis by diabetes type, COVID-19 severity, and COVID-19 vaccination status, overall and in population subgroups. Notably, excess diabetes incidence by time period since infection could also be quantified. Because health care in the UK is universal and free at the point of delivery, almost the entire population is registered with primary care. The findings are therefore likely to be generalisable to the UK and internationally. We found that, before the availability of COVID-19 vaccination, a COVID-19 diagnosis (vs no diagnosis) was associated with increased incidence of type 2 diabetes, which remained elevated by approximately 30% beyond 1 year after diagnosis. Although still present (with around 30% excess incidence at 8 weeks), these associations were substantially attenuated in vaccinated compared with unvaccinated people. Excess incidence was greater in people who were hospitalised with COVID-19 than those who were not hospitalised after diagnosis. The incidence of type 1 diabetes was elevated up to, but not beyond, 1 year after COVID-19 diagnosis. Around 60% of people diagnosed with incident type 2 diabetes after COVID-19 still had evidence of diabetes 4 months after infection.

Won't you please stop misrepresenting studies?
Why do you think it was necessary for you to resort to another, older, study and quote its "CONCLUSIONS" instead of the conclusions from the study in The Lancet?

Findings
16 669 943 people were included in the pre-vaccination cohort (Jan 1, 2020–Dec 14, 2021), 12 279 669 in the vaccinated cohort, and 3 076 953 in the unvaccinated cohort (both June 1–Dec 14, 2021). In the pre-vaccination cohort, aHRs for the incidence of type 2 diabetes after COVID-19 (compared with before or in the absence of diagnosis) declined from 4·30 (95% CI 4·06–4·55) in weeks 1–4 to 1·24 (1·14–1.35) in weeks 53–102. aHRs were higher in unvaccinated people (8·76 [7·49–10·25]) than in vaccinated people (1·66 [1·50–1·84]) in weeks 1–4 and in patients hospitalised with COVID-19 (pre-vaccination cohort 28·3 [26·2–30·5]) in weeks 1–4 declining to 2·04 [1·72–2·42] in weeks 53–102) than in those who were not hospitalised (1·95 [1·78–2·13] in weeks 1–4 declining to 1·11 [1·01–1·22] in weeks 53–102). Type 2 diabetes persisted for 4 months after COVID-19 in around 60% of those diagnosed.Patterns were similar for type 1 diabetes, although excess incidence did not persist beyond 1 year after a COVID-19 diagnosis.

ETA: As for 'what concerns you more than diabetes', i.e cognitive effects:
Can Diabetes Lead to Cognitive Impairment? (NIH, July 28, 2021)
Q: Are people with diabetes more likely to develop cognitive impairment than people without diabetes?
A:
Yes. Studies have demonstrated that people who have diabetes, compared with people without diabetes, are more likely to develop cognitive problems. Older adults with diabetes have higher incidences of dementia, Alzheimer’s disease, and vascular dementia External link than those with normal glucose tolerance.
 
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Nya forskningen visar: Allvarlig covid kan leda MS (SverigesRadio.se, Dec 2, 2024)
  • Covid kan vara en utlösande faktor för sjukdomen multipel skleros, MS, visar forskning från Universitetssjukhuset i Örebro.
  • Men det är ovanligt, säger forskaren bakom studien, Scott Montgomery, professor i klinisk epidemiologi.
  • Nu hoppas han att resultatet ska hjälpa dem som drabbas, men ger också ett råd till självhjälp.
New research shows: Serious COVID-19 may lead to MS
* Research from the University Hospital in Örebro shows that COVID-19 may be a factor that triggers the disease multiple sclerosis, MS.
* But it is unusual, says the researcher behind the study, Scott Montgomery, professor of clinical epidemiology.
* Now he hopes that the results will help those affected, but also gives advice for self-help.

Covid-19 may raise risk of developing multiple sclerosis (NewsMedical, Nov 29, 2024)
Scott Montgomery examined the records of all patients with Covid-19 that were admitted to hospital in Sweden between 2020 and 2022.
The results showed that nearly 26 per 100,000 patients with serious Covid-19 subsequently developed MS. This was more than double the risk than in those without a Covid-19 diagnosis.
"I want to make it clear that MS is an uncommon disease and very few people in this study had an MS diagnosis linked with Covid-19. Approximately 26 people with new-onset MS per 100,000 with serious Covid-19 is only 0.02%."
Scott Montgomerysuspects that the number who are diagnosed with MS following severe Covid-19 will increase over the years after the pandemic.
"It can take up to 10 to 20 years until an MS diagnosis following a relevant exposure to the brain or spinal cord. The extent to which serious Covid-19 is a cause of MS will become clearer in several years," says Scott Montgomery.

Something to look forward to for researchers, I guess.
I bet Anders Tegnell didn't expect that Swedish researchers would begin to deliver the kind of results that are currently coming from Swedish research institutes.
 
New research shows: Serious COVID-19 may lead to MS
* Research from the University Hospital in Örebro shows that COVID-19 may be a factor that triggers the disease multiple sclerosis, MS.
* But it is unusual, says the researcher behind the study, Scott Montgomery, professor of clinical epidemiology.
* Now he hopes that the results will help those affected, but also gives advice for self-help.



Something to look forward to for researchers, I guess.
I bet Anders Tegnell didn't expect that Swedish researchers would begin to deliver the kind of results that are currently coming from Swedish research institutes.
I suspect this is untrue. There may be an association; but as we all know association does not equal causation.

We have a good understanding of triggers for MS and I don't think SARS-CoV-2 infection fits well as a cause as opposed to triggering exacerbations.
 
Do we actually have "a good understanding of triggers for MS"? Many sites still say that we don't. They also say that MS is probably an autoimmune disease:
Multiple sclerosis (Mayo Clinic)
Causes
The cause of multiple sclerosis is not known. It's considered an immune-mediated disease in which the body's immune system attacks its own tissues. In MS, the immune system attacks and destroys the fatty substance that coats and protects nerve fibers in the brain and spinal cord.
(...)
It isn't clear why MS develops in some people and not others. A combination of genetics and environmental factors may increase the risk of MS.
Besides:
Risk factors
(...)
  • Certain infections. A variety of viruses have been linked to MS, including Epstein-Barr. Epstein-Barr is the virus that causes infectious mononucleosis.
Your suspicion seems to clash with what has been suspected since the early days of the SARS-CoV-2 pandemic:
Covid-19 and autoimmunity (NIH/PMC, June 11, 2020)
High risk of autoimmune diseases after COVID-19 (Nature, April 3, 2023)
Patients with COVID-19 have 43% increased risk for new-onset autoimmune diseases (Healio, Aug 31, 2023)
New-onset autoimmune disease after COVID-19 (Frontiers, Feb 8, 2024)
New Evidence Supports Autoimmunity as One of Long COVID's Underlying Drivers (Yale School of Medicine, July 22, 2024)
Notice that the study found (more than) a doubling of the risk, so please elaborate on your suspicion that it is untrue that serious COVID-19 may lead to MS.

ETA:
Awakening the sleeping giant: Epstein-Barr virus (EBV) reactivation by biological agents (Pathogens and Disease, Jan 27, 2024)
In a clinical study, two-thirds of long-COVID patients had EBV reactivation ...
 
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So much for the moronic idea of 'immunity debt' invented by minimizers to account for the rise in all the other infectious diseases 'after' the COVID-19 pandemic:
Long Covid-19 Weakens Immunity in Children, Increases Risk of Infections: Study (News18, Dec 3, 2024)
Children experience weakened immunity and bacterial infections after suffering from long Covid-19 syndrome, a study published in the medical journal Nature has revealed.
Persistent fatigue was the most common symptom in children with long Covid syndrome, while the majority of children often complained about anxiety.
Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity (Pediatric Research, Nov 27, 2024) - not a large study: 129 children.

It is not a new discovery that the C19 infection and not the lack of infections is the problem, but it's good to see it confirmed. (The media, however, loves immunity debt!) It would be better to see precautions implemented to protect (not just) children from the infection and its sequelae.
 
Do we actually have "a good understanding of triggers for MS"? Many sites still say that we don't. They also say that MS is probably an autoimmune disease:

Besides:

Your suspicion seems to clash with what has been suspected since the early days of the SARS-CoV-2 pandemic:
Covid-19 and autoimmunity (NIH/PMC, June 11, 2020)
High risk of autoimmune diseases after COVID-19 (Nature, April 3, 2023)
Patients with COVID-19 have 43% increased risk for new-onset autoimmune diseases (Healio, Aug 31, 2023)
New-onset autoimmune disease after COVID-19 (Frontiers, Feb 8, 2024)
New Evidence Supports Autoimmunity as One of Long COVID's Underlying Drivers (Yale School of Medicine, July 22, 2024)
Notice that the study found (more than) a doubling of the risk, so please elaborate on your suspicion that it is untrue that serious COVID-19 may lead to MS.

ETA:
 
(...) Interesting fellow [ZDoggMD] because he is friends with both Dr. Paul Offit and Dr. Vinay Prasad. Very reasonable doc though I'm not into the mediation stuff that seems to fascinate him.
Dr. Vinay Prasad: "Sabotaging RFK Jr's Confirmation Will Increase Vaccine Hesitancy" & "Doctors Criticizing RFK Jr. Paved the Way for His Ascendancy" (Science-Based Medicine, Dec 6, 2024)

ZDoggMD and Vinay Prasad are still BFFs, apparently!
Why Trump Won & What It Means for Healthcare (The VPZD Show on YouTube, Nov 8, 2024 - 1h 35m)
 
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