I've heard Maresca saying that but then of course, he would (as he pedals backwards furiously). How can it be crucial only if the test is positive - does that mean that if it's Meredith or Guede's DNA then Amanda and Raffaele are definitely, definitely guilty, but if it's not then they're only definitely guilty? If that were the case there'd be no point doing the test at all.
I reckon these are the three ways it could go: if Meredith's DNA, the court will say it's probably the murder weapon; if Guede's, they'll say it 'clarifies their subjective positions' and that Guede probably held it, not Amanda; and if it's negative, it's probably not the murder weapon. So if there's nothing on it or it's unidentified or unclear - much the more likely outcome - that would most likely be the end of the knife.