http://www.fluoridealert.org/conference/2006/thiessen.htm
THIESSEN: I think it's important to know that our committee unanimously said that the existing regulatory limits for fluoride in drinking water are not protective. We did that on the basis of health effects that have long been associated with fluoride: dental effects and skeletal effects.
We also pointed out a number of areas where there are, or seem to be, adverse health effects that have not historically been associated with fluoride or at least not in the mainstream literature -- the government agency literature and such. And we said these need to be looked at, that some of these could be important for Americans even at the regular drinking water levels, even without approaching the limits.
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CONNETT: And when you looked at the doses that were associated with the effects on the thyroid in iodine deficient and non-iodine deficient individuals how did they compare with the doses that many Americans would receive?
THIESSEN: Many Americans are getting fluoride exposures in the ranges associated with thyroid effects, especially if there's an iodine deficiency. We're talking average levels of fluoride exposure of around 0.03 milligrams-per-kilogram per day for adults in the US. That's average. Many are above that, many are below that. And the levels of fluoride exposure at which one sees thyroid effects in some individuals -- not everybody -- with an iodine deficiency are right around that same range.
CONNETT: So there's an overlap there?
THIESSEN: There's an overlap there.
CONNETT: Now with water fluoridation, it's a policy where we sort of are treating everyone with the same general dose, or concentration, of fluoride. What would be your response to the notion that we can treat everyone in the population -- or assume that everyone in the population is going to respond the same -- to the same dose of fluoride?
THIESSEN: Doesn't matter what contaminant you're dealing with, to expect the same response for everybody is silly. It's not taking into account dietary variability, it’s not taking into account variability of water consumption, it’s not taking into account genetic susceptibility to possible effects of whatever contaminant you're dealing with.
CONNETT: And is there evidence to suggest that individuals respond differently to fluoride? Are some people more susceptible to fluoride?
THIESSEN: There is evidence, from a variety of sources, that individuals respond differently to fluoride exposure. It depends on what endpoint you're looking at, but certainly there are differences in nutritional aspects between individuals -- those who are getting adequate supplies of nutrition generally and certain elements in particular. There are also genetic variants within the population. Different genetic forms of an enzyme may respond differently. That's certainly there. There's also -- individuals vary widely in their exposure, because they have different sources of exposure. Their water intake varies so widely, that sort of thing. I would expect for just about anything to see a wide range of population response.
CONNETT: So do you have any concerns about water fluoridation and if so what would those concerns be?
THIESSEN:
Speaking as a scientist, based on the information I have looked at, we're dealing with uncontrolled and unmonitored exposures to an agent that is known to have adverse effects on humans. I have no problem with it being in the list of drugs and people having it with a prescription, as with any others, if there's a doctor -- or appropriate medical professional -- monitoring the exposure and the side effects and whether its effective.