joobz
Tergiversator
- Joined
- Aug 31, 2006
- Messages
- 17,998
Acetylating asprin allows it to be more clinically active with lower doses. The acetyl version isn't pharmacologically active until it is deacetylated in the cytosol where it gets converted back to the active salicylic acid (SA) form. This allows it to distribute throughout the body and be converted locally in cells where it can exert its function. This way, you don't need to overload the body and stress the clearance organs.Ouch - seem to have touched a nerve... Mea culpa - I said it was a 'version' of salicylic acid, which was perhaps not precise enough. My point was that the 'original' was derived from a plant source, as is the case with many modern drugs.
I do not think you touched any soft spot here. You were just clearly corrected by Drkitten. Simply, and several examples have been given, that the distinction between natural chemicals and man-made chemicals is a "man-made" distinction. the body doesn't care. You need to evaluate each on it's own terms.