No less important than any of the above is the action of atropine on the cerebrum. This has long been a debated matter, but it may now be stated, with considerable certainty, that the higher centres are incoordinately stimulated, a state closely resembling that of delirium tremens being induced. In cases of poisoning the delirium may last for many hours or even days. Thereafter a more or less sleepy state supervenes, but it is not the case that atropine ever causes genuine coma. The stuporose condition is the result of exhaustion after the long period of cerebral excitement. It is to be noted that children, who are particularly susceptible to the influence of certain of the other potent alkaloids, such as morphine and strychnine, will take relatively large doses of atropine without ill-effect.
