articulett said:
If you have a mutation that makes some of your blood cells sickle shaped--you have a phenotypic change that gives you a survival/reproductive advantage in malarial regions. If you move out of malarial regions--the phenotypic change might hang out in your descendants through genetic drift. Or it might disappear. It becomes deleterious when an offspring is homozygous.
But it sure wasn't selected randomly! It was selected because it conferred an advantage...it was then passed on in these successful genomes even when it no longer conferred an advantage to its carriers because it was a neutral mutation in successful replicators--unless (or until) an offspring had two copies...in which case it became deleterious and usually those affected could not pass on their genes. And that is not "random" either. Having sickle cell anemia reduces reproductive fitness. Not randomly! Because having all your blood cells sickle shaped makes them get clogged up and produce infarctions and clots and priapism and other health problems. Yet you call this random! The first sickle cell mutations (it evolved numerous times and there are numerous mutations) came about randomly. But they were selected for or against based on pheotypic changes they code for in the vectors that copied them.
It was not
selected "randomly", but the proportion of people with sickle-cell anaemia would depend on the percentage reproductive advantage this confers compared to individuals without this trait.
An example:
For simplicity, I am assuming that both full sickle-cell anaemia and maleria stop an individual from reproducing, and being a carrier of sickle-cell anaemia confers 100% protection.
If everyone in an area without any form of protection would get maleria, then the sickle-cell anameia carrierswould have an infinite advantage over non-carriers, as on average, 50% of their offstpring will be immune from maleria and not have sickle-cell anaemia.
In a different area there is no maleria, so these carriers would be at a 25% disadvantage, because on average that number would have full sickle-cell anaemia.
In between there would be different levels of infection, and different reproductive advantages/disadvantages for the sickle-cell carriers.
This can be assessed with a probabilistic treatment.
cyborg said:
mjio, a test.
THTTHTTHTHTHTTHHTHTHTHT
Is that coin random? Can the trials be described by a probability distribution?
TTTHTTTTHTHTTTHTHTTTHTH
Is that coin random? Can the trials be described by a probability distribution?
THTHTHTHTHTHTHTHTHTHTHT
Is that coin random? Can the trials be described by a probability distribution?
TTTTTTTTTTTTTTTTTTTTTTT
Is that coin random? Can the trials be described by a probability distribution?
It depends, as there are (23?) throws, any of those set of outcomes are equally unlikely at 2
-23. If you are talking about the actual numbers of heads and tails, then it follows a binomial distribution.
ivor the engineer said:
Ok, I've been out of this one for a while, but I have a question for the randomites. Do you believe what happens next is constrained completely by all of what happened before?
I'm guessing the answer will be "no". If so, how much wiggle room do you think there is for the outcome of the next event, given all of the events up to that point?
How would you tell the difference between x+1 = f(x) + err, where err is a truly random component and x+1 = f(x) + g(x-1, x-2, ..., x-N), where g() is a non-linear function from hell over all events till the present?
I would say that for your last question that the only way of analysing that is statistically, and it is a moot point whether it is random, or pseudorandom. However, if the nonlinear function has positive feedback loops that magnify any random compomnents, then it is a moot point, because the randomness is magnified to a significant level.
Population bottlenecks are far more affected by such random events, and that is where a lot of evolution occurs.
After the KT impact, whether you think of that as random or pseudorandom, the population of surviving organisms was vastly reduced.
That availiable ecological niches would be filled was a very near certainty.
What would fill them, and how, was not.
Do you believe what happens next is constrained completely by all of what happened before?
Heavily influenced, plus magnification of true quantum randomness, as an other effect.