If it were, spectroscopic analysis would indicate that. Since there isn't a whole lot of variation in Boron concentration in observable star systems, it would require, as noted before, a highly idiosyncratic concentration in a small area. Since Boron production is via cosmic ray interaction rather than stellar nucleosynthesis, it is highly unlikely for such a concentration to exist.Though we generally agree, I would say that the low amounts of Boron in the Solar system shouldn't be a limitation here. Boron could be more common in other star systems or galaxies.
I think, however, you could establish the very first common frames of reference by using principals found throughout the galaxy. In a similar way, when early explorers first encountered native peoples around the world there was often little or no frame of reference from a cultural point of view, but we still had the basics in common; land, water, sky, etc.
By that same principal, we and any advanced lifeform have things in common; elemental particles, orbital patterns, stars, pulsars, etc.
The problem is communicating those commonalities rely on a common frame of reference. With other Homo sapiens we are the same species, from the same evolutionary pathway, and therefore we see in the same spectrum and hear in the same frequency, and our brains process information in the same way. Finding a common frame of reference is simple.
With Aliens, there is no way to know if they even see the same spectrum or hear the same frequencies (although some overlap is expected, how much will likely vary). And while some things are universal, such as mathematical relationships, expressions of these universals can vary considerably, so the problem of notation of even the most basic mathematics can be a substantial challenge to overcome. And again, that's assuming they process information in the same way. Human brains are highly differentiated and linear. Imagine the difficulties inherent in communicating with a species capable of complex cognitive multitasking.