I think we can say for sure that exoskeltons are out unless they develop in wildly different gravity, extreme low g has issues with atmosphere retention long enough for evolution. While it's possible that invertibrates such as an octopus related creature could develop intelligence, I believe that it could only be tool wielding in an environment that supports it's body (such as in the ocean).
It's level of symmetry is likely to be a function of it's environment, a highly predatory environment is likely to favour creatures with 360 degree vision, but you may then lose other senses, like depth perception. I too think that it will have a symmetry similar to ours, though numbers of limbs, digits, layout and mechanisms of limbs may well be different.
The number of limbs is a good example to draw on. Given the importance of tool-use in developing intelligence, it seems pretty much a given that any animal attaining higher intelligence needs to at least have one set of "spare" limbs for manipulating tools. Let's call them "arms". I say spare, because the evolution of chimpanzees suggests that advanced tool use only emerges once a pair of limbs can be dedicated full-time to the task (chimpanzees will use tools locally, but as they are normally quadrupedal they don't transport their tools around with them, discouraging them from putting time and effort into making more complex tools to keep).
Limbs are also the most efficient and effective way of achieving locomotion on land, so it stands to reason any higher-intelligence organism will also require limbs for travel. Let's call them legs.
The question is, then, how many?
What's crucial about limb development is the configuration has to be established fairly early in the organism's evolution, long before it starts using tools (it starts using tools because it can, it doesn't evolve limbs so it can use tools). So we have to look at alternative benefits to those limbs. And remember, once the limbs reach a level of complexity, evolution is going to work against the emergence of new limbs because those will have to arise first as simple proto-limbs, which won't offer any tangible benefit to an organism that already has developed limbs.
So we have to ask where limbs came from.
Well, they came from pectoral fins on primitive fish. They provided maneuverability and buoyancy in water. Additional sets of limbs emerging further alone the spine offer no advantage as they lie within the shadow of the leading limbs (much like the reason multiple ranks of wings on aircraft don't work).
So at the early stage of vertebrate development we're pretty locked into a single pair of limbs. Once they start venturing out of water only having two limbs isn't ideal; the tail drags on the ground causing friction which slows the creature down and can cause injury. Even basic proto-limbs offer a benefit by slightly elevating a part of the tail, thus slightly reducing contact with the ground. Each subsequent enlargement of the proto-limb increases the benefit. By this method you gradually develop a second pair of limbs.
But what about three or four pairs of limbs? Well, they don't offer any advantage. You only need four limbs. An organism with one pair of developed limbs and one pair of proto-limbs is actually at an advantage over an organism with two pairs of proto-limbs because both gain the advantage of an elevated body, but one does it more efficiently, only having to supply energy to one pair of limbs.
Once the second pair are in place any additional proto-limb pairs are just hanging around in mid air, offering no advantage whatsoever. On the other hand those little appendages offer disadvantages. For one it's tissue/muscle/bone requiring energy, for no benefit. So the animal is less efficient. Secondly, the protrusions offer places the animal can be seized, or can get caught on things; endangering it, again for no benefit.
Thus a third or fourth pair of proto-limbs is a net evolutionary loss, and never develop.
That's why any advanced land-based life-form will be bipedal with four limbs.