Sure, but is that true for the filibuster? If he lost his seat by being a good party loyalist, he could probably secure guarantees to serve in a future president's cabinet (he should make sure his taxes are in order or his hopes could get Daschled). As for keeping himself electable, Manchin voted to convict Trump for the Ukraine scheme. Cheney and Kinzinger voted against those articles of impeachment.
Maybe prime time television can boost her chances. Probably not. I'd guess the mortgages on her fabulous properties have been paid off and she'll be just fine. She'll have the choice of being a high-profile martyr (with more of the same slobbering press coverage), and then spending more time with her family. I wouldn't be surprised if she's already plotting a return to public life. She can't expect Trumpism to find enduring success. If she fails to sabotage Trump, she can emerge from the rubble prepared.