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Merged Instinct & Immunity? / Innate immunity?

Kumar said:
Ok. Do we account status of innate immunity while doing any treatment?
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Perhaps you could define what you mean by "innate immunity". The term doesn't seem to correspond to what we know about what the immune system actually does, which is to react to antigens it encounters. Immunity is the result of environmental challenges to the immune system as the organism encounters them: it is not "innate".

I have not seen any refenrence like "altred, weak or strong innate immunity, neither innate immunity compromised nor its supression.
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"Suppression" is a concept that has been made up by homoeopaths to discourage their customers from seeking treatment from proper doctors who might be able to offer effective treatments, thus depriving the homoeopaths of the income from all those repeat consultations. It does not actually exist.
 
Mojo said:
Your link doesn't seem to be about "innate immunity". It is about excessive iron loading in specific tissues and cells promoting some forms of illness.
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You should had seen, how our body system having innate defence response in nett survival benefit even at some cost of losing iron.
 
Mojo said:
Perhaps you could define what you mean by "innate immunity". The term doesn't seem to correspond to what we know about what the immune system actually does, which is to react to antigens it encounters. Immunity is the result of environmental challenges to the immune system as the organism encounters them: it is not "innate".




"Suppression" is a concept that has been made up by homoeopaths to discourage their customers from seeking treatment from proper doctors who might be able to offer effective treatments, thus depriving the homoeopaths of the income from all those repeat consultations. It does not actually exist.
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I had provided a link. Still;

Innate ( Nonspecific ) Immunity - The term, Innate immunity, refers to the basic resistance to disease that a species possesses - the first line of defense against infection.
The characteristics of the innate immune response include the following:

Responses are Broad-Spectrum (non-specific)
There is no memory or lasting protective immunity
There is a limited repertoire of recognition molecules
The responses are phylogenetically ancient
Potential pathogens are encountered routinely, but only rarely cause disease. The vast majority of microorganisms are destroyed within minutes or hours by innate defenses. The acquired specific immune response comes into play only if these innate defenses are breached.

http://bioweb.wku.edu/courses/biol328/innate.htm
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Innate: natural; inborn, inherent, somewhat "Natural defence responce".
 
Stress hormones,Stress compromising, Sympathetic nervous system--fight or flight response, weak/strong immunity, immue system compromising, silent death/damage etc. may be relevant to it.
 
Yes, that stress can affect the immune response is widely accepted. I'll assume that you're intersted mainly in stress due to enviromental factors (i.e. huge work loads, dangerous conditions, destructive social conditions etc) rather than rather than the stress the body sustains when affected by massive trauma or disease?
In short, the detrimental effects of stress on the immune system seems to be caused by disruptions in lymfocyte activity due to prolonged elevation of glucocorticoid levels, wich can be caused even by very short-term, high-stress situations such as exposure to violent crime, accidents and so on.
There's a great deal of articles on the subject on google scholar for a more in-depth view.
 
Sawbones79 said:
Yes, that stress can affect the immune response is widely accepted. I'll assume that you're intersted mainly in stress due to enviromental factors (i.e. huge work loads, dangerous conditions, destructive social conditions etc) rather than rather than the stress the body sustains when affected by massive trauma or disease?
In short, the detrimental effects of stress on the immune system seems to be caused by disruptions in lymfocyte activity due to prolonged elevation of glucocorticoid levels, wich can be caused even by very short-term, high-stress situations such as exposure to violent crime, accidents and so on.
There's a great deal of articles on the subject on google scholar for a more in-depth view.
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Welcome. Yes, I wouold like to better understand about chronic stress due to modern lifestyle, modern environment in big cities, unhygienes etc.. Acute stress may not be a reason to immune compromising but chronic stress can, as indicated in OP link.
 
Actually, acute stress can cause prolonged glucocorticoid elevation, one of my mentors in med school actually measured rather elevated glucocorticoid levels in long distance sailors for several weeks after sailing in iceberg-laden waters. The stress response in the human body seems to be identical whether a reaction to a buffalo attack or difficult school exam.

EDIT: Apparently I've dropped into an ongoing discussion, but since the threads merged I'm not really clear on what's being discussed.
 
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Sawbones79 said:
Actually, acute stress can cause prolonged glucocorticoid elevation, one of my mentors in med school actually measured rather elevated glucocorticoid levels in long distance sailors for several weeks after sailing in iceberg-laden waters. The stress response in the human body seems to be identical whether a reaction to a buffalo attack or difficult school exam.

EDIT: Apparently I've dropped into an ongoing discussion, but since the threads merged I'm not really clear on what's being discussed.
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Long distance sailing can be a chronic stress but buffala attack as an acute stress.

I don't know, how this topic is merged. I am requesting to moderator.
 
Kumar said:
Long distance sailing can be a chronic stress but buffala attack as an acute stress.

I don't know, how this topic is merged. I am requesting to moderator.
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From what I've read of such research, acute stress might well cause lingering systemic effects regardless of the resolution of the situation as such.
As for the merging, from what I understand of the previous thread it seems to tie in reasonably with the content of the new OP I tried to answer.
I'm not sure what theory you're wishing to discuss concerning stress and the immune system, I'm afraid. Are you stating that modern society causes immune defects due to a level of chronic stress not prevalent in earlier human societies?
 
Sawbones79 said:
From what I've read of such research, acute stress might well cause lingering systemic effects regardless of the resolution of the situation as such.
As for the merging, from what I understand of the previous thread it seems to tie in reasonably with the content of the new OP I tried to answer.
I'm not sure what theory you're wishing to discuss concerning stress and the immune system, I'm afraid. Are you stating that modern society causes immune defects due to a level of chronic stress not prevalent in earlier human societies?
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This topic was quite new. It is unreasonable to merge it. Now It become difficult to discuss this issue here. Thanks.
 
Kumar said:
This topic was quite new. It is unreasonable to merge it. Now It become difficult to discuss this issue here. Thanks.
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Ok. Going back through the thread I'm not certain I can really understand what thesis you're proposing regarding immunity and its relation to genetic and enviromental factors. Would you mind trying to clarify it a bit?
 
Sawbones79 said:
Ok. Going back through the thread I'm not certain I can really understand what thesis you're proposing regarding immunity and its relation to genetic and enviromental factors. Would you mind trying to clarify it a bit?
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Simply, I am trying to understand relationship between Chronic stress & Immune comporising/tolerance in view of link I provided.

Any odd exposure which is not natural to us, to which we don't have inharent sense of right & wrong ot to which we are neither evolved nor habituated, can cause some stress to us. It it such exposure is chronic it should cause chronic stress. If at the time of need, our immune system is not stimulated, it can cause unnoticed or unfelt harm to us. Somewhat a silent killing or damage.
 
Kumar said:
Simply, I am trying to understand relationship between Chronic stress & Immune comporising/tolerance in view of link I provided.

Any odd exposure which is not natural to us, to which we don't have inharent sense of right & wrong ot to which we are neither evolved nor habituated, can cause some stress to us. It it such exposure is chronic it should cause chronic stress. If at the time of need, our immune system is not stimulated, it can cause unnoticed or unfelt harm to us. Somewhat a silent killing or damage.
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Yes, chronic stress impairs the immune system to some degree, as stated
above. Such stress can result from a number of causes such as destructive social situations, unmanagable workload as well as severely threatening situations such as war, risk of famine etc.
Going out on a limb I'd say neither the biomedical effects of stress nor the causes of such have changed much during human history, but the impact of stress on general health has probably been very insignificant compared to famine, war and infectious disease during most of the existence of humanity.
With the dramatically improved health and general quality of life brought on by improvements in living standards and modern science-based medicine (vaccines are a major point) the effects of stress are probably more noticeable in the general helath of the population.
 
There are many sites giving details of stress & chronic stress. That link, somewhat indicates that acute or low level of stress may be beneficial( it may motivate and stimulate fight or flight response). One thought can be there that immune stimulation may be dependant on acute/low stress but if it is chronic stress, it may compromise, weaken or cause tollerance to the immune response. So we can concentrate on strengthening & weakening of immunity as a result to stress.
 
Kumar said:
Medicine has many meanings eg;

"med·i·cine/ˈmedisən/Noun
1. The science or practice of the diagnosis, treatment, and prevention of disease (in technical use often taken to exclude surgery).
2. A drug or other preparation used for the treatment or prevention of disease. "
http://www.google.co.in/search?hl=e...PrIJDLrQflou2OBg&ved=0CCwQkQ4&biw=802&bih=381

Tell me, what do you meant?
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Either. Do you include these in your "Any odd exposure which is not natural to us, to which we don't have inharent sense of right & wrong ot to which we are neither evolved nor habituated"?
 
Mojo said:
Either. Do you include these in your "Any odd exposure which is not natural to us, to which we don't have inharent sense of right & wrong ot to which we are neither evolved nor habituated"?
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Mojo, Just contribute.
 
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