FLiRTing with KP.2
Well, if "the CDC's main web site doesn't even have Covid-19 on its main page," it just must mean that the pandemic is over, mustn't it?!
The mentioned preprint study:
As always, how this plays out remains to be seen.
Well, if "the CDC's main web site doesn't even have Covid-19 on its main page," it just must mean that the pandemic is over, mustn't it?!
In a recent preprint study posted to the bioRxiv server, a team of researchers analyzed the virological characteristics and epidemiological impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) FLiRT variant KP.2, which has demonstrated increased transmissibility and immune resistance.
Background
The rapid emergence and diversification of the JN.1 variant and its descendent, KP.2, which shows significant alterations in Spike (S) protein structure and increased resistance to existing vaccines, underscores the necessity for further research to understand the implications for public health and vaccine development.
New SARS-Cov-2 KP.2 variant defies vaccines with higher spread, study warns (MSN.com, April 30, 2024)
The mentioned preprint study:
KP.2 has higher viral fitness and potentially becomes the predominant lineage worldwide. Indeed, as of the beginning of April 2024, the estimated variant frequency of KP.2 has already reached 20% in United Kingdom.
The pseudovirus assay showed that the infectivity of KP.2 is significantly (10.5-fold) lower than that of JN.1. We then performed a neutralization assay using monovalent XBB.1.5 vaccine sera and breakthrough infection (BTI) sera with XBB.1.5, EG.5, HK.3 and JN.1 infections. In all cases, the 50% neutralization titer (NT50) against KP.2 was significantly lower than that against JN.1. Particularly, KP.2 shows the most significant resistance to the sera of monovalent XBB.1.5 vaccinee without infection (3.1-fold) as well as those who with infection (1.8-fold). Altogether, these results suggest that the increased immune resistance ability of KP.2 partially contributes to the higher Re more than previous variants including JN.1.
Virological characteristics of the SARS-CoV-2 KP.2 variant (bioRxiv)
Graph (Figure 5) in both tweet and surveillance report of the weekly positivity (%) for SARS-CoV-2 by year (2022-23 & 2023-24), UK Health Security Agency.HOLY ****
That's the biggest rise in covid positivity in a single week for nearly two years.
That's a 54% leap
I flipping told you
This is going to be a very nasty wave.
flu and covid report: National influenza and COVID-19 surveillance report: Week 18 report (up to week 17 2024 data) 2 May 2024
The UKHSA is completely asleep at the wheel. Drunk even.
It's just crazy, I thought that there was a bit of a spike going on based on the number of people I had heard of who were ill.
But if that same % increase happens next week, and then it increases at only 1/2 the rate the following week, it'll be the biggest wave in two years.
tern (X, May 2, 2024)
As always, how this plays out remains to be seen.
The relative calm in the US regarding Covid-19 could be disrupted by a new cluster of SARS-CoV-2 variants, collectively known as the "FLiRT" variants.
These variants have emerged from the JN.1 lineage, responsible for a search in Covid-19 last winter. The most notable among these, the KP.2 variant, represented approximately 25% of the newly sequenced cases in the last two weeks of April, according to data from the Centers for Disease Control and Prevention (CDC).
Covid-19 'FLiRT' variants: What you need to know (Times of India, May 2, 2024)
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