Thousands of endogenous retroviruses exist in human DNA. HERVs account for 98,000 elements and fragments—nearly 8%—of the human genome.
[11] According to a study published in 2005, no HERVs capable of replication had been identified; all appeared to be defective, containing major deletions or nonsense mutations. This is because most HERVs are merely traces of original viruses, having first integrated millions of years ago. However, one family of viruses has been active since the divergence of
humans and
chimpanzees. This family, termed HERV-K (HML2), makes up less than 1% of HERV elements but is one of the most studied. There are indications it has even been active in the past few hundred thousand years, e.g., some human individuals carry more copies of the virus family than others
[12].