Low-margin manufacturing has been outsourced. High-added-value manufacturing is still possible in the UK, but it will be harder after Brexit
Ouch.
Impressive, but somewhat overkill for pointing out the problems with "just hiring offices at Canary Wharf".
I'm sure I'd miss a fair number of factors out, but know enough to see that is silly.
I'm sure I'm missing a fair number of issues, but an appropriately qualified potential pool of workers willing to work where you are is obviously key, and which is hard to recreate once it's gone. Likewise with any specialist support industries and infrastructure. And I suppose as few barriers to the clients - so having different regulatory requirements could be problematic.