Aboman, welcome to the forum. not sure If i can help out, but i will try. first of all, we are talking about DNA from the nucleus, which Dr. Ketchum seems to indicate that she has a complete genome from 3 individuals. I find that exceedingly hard to believe. first of all, you are talking about 10 billion base pairs here. I really doubt that she would have the equipment, the computer power, software, technical expertise, and computer storage available to her to allow those 10 billion base pairs to be stored and compared.
I may be wrong on that, but it seems pretty far fetched to me. instead what I think she has (if anything, remember she has not provided a single base pair of data yet, nor a paper outlining her techniques and methods and analysis and conclusions), all we have at this point is a press release from an amateur PR person, who apparently plagerized part of my last post and put it up on Melbas facebook page.
Attn. Ms. Lynne, please either give proper credit to your sources of information, or remove them from Dr Ketchums facebook page!
anyway back to my point, I think the most likely scenario is that she had the DNA run by several commerical companies that specialize in large data management. i suspect she would have used a company called "23 and me" as well as a few others. They were not going after producing whole genomes, but were instead focussed on SNP's. Single Nucleotide Polymorphisms. essentially there are many sites in your DNA that seem to mutate more than others, and many of these involve a single base (nucleotide) change in the DNA. Those are easily identified because they will have chains of nucletides before and after the SNP that are the same across the board (I'm obviously simplifying this here).
Modern technology has lead to the development of synthetic DNA cartridges that essentially look through a DNA sample and look for about 1/2 a million different SNP sites, and catalog those sites, and their differences.
I suspect that is what they really have - not a complete genome, but a catalog of SNP for each of the 3 unique samples. SNP's are used widely in human genomics, looking at drug affinities and efficacy for example,and has lots of use to population geneticists. They have been looked at in using to differentiate species, and have been sucessfull in doing that in some cases.
So i suspect from this collection of 1/2 million SNP' Melbas crew selected a small suite of them, and will contend that this particular group of SNP will be unique to Bigfoot!
My problem with that whole idea: all it shows is individual variation. and just because you cannot find that individual variation in any on line data base, that does not make it non human. Gen bank and other available databases are not comprehensive for the total of humanity. They are very small samples of humans, and were never intended, nor are they capable of capturing or illustrating the complete genetic diversity of humans. looking at all potential combinations of SNPs A very small subset of the 1/2 million SNP's on a chip could mathmatically exceed the number of humans on the planet. i would have to work out that number, but essentuially a tiny subset of those half million SNP sites will give you individuality.
So its all about what sites or markers you chose, how you statistically treated them, and how those statistics drove your conclusions.
we just don't know! we are in the same place we were 2.5 years ago, when Melba first started saying they were close to releasing the paper, and just had to do final edits. 2 and a half years, no change!
hoaxing? i doubt it. at least on her side, I do think however that some unscrupulous individuals may have tried to find a donor of DNA - human, who they did not think would be represented in genbank. someone of a small ethic heritage, or with religious beliefs that preclude most of their group from donating DNA. That would skew the chances that the sequences would appear to be unique!
This is not my area at all so please forgive my ignorance, but Calwaterbear should be able to answer...
Is it possible that Ketchum has hoaxed 'the unique' (aka angel) bits of the nuDNA? As in if she releases her data (here I'm assuming she would release raw data), could she have edited bits to show something 'weird'. Those bits would be the angel/BF DNA in her paper obviously.
Then when nobody is able to replicate her findings they A) don't have real BF samples or B) don't have access to her (patented?) markers to identify said BF DNA?