I already explained this. The difference is that in one case it is rational to take any positive-expectation bet offered to you, and in the other it is not. That right there is proof that total uncertainty is not the same thing as a known 50/50 proposition.
You've said this a few times, but I don't see that you've demonstrated it.
Let's look at your two scenarios again:
1. Two runners of equal ability are facing off against each other.
2. Two runners of unknown ability are facing off against each other.
Someone offers you a favorable bet. In which circumstance is it necessarily correct to accept it?
Neither. In the first circumstance, the offerer may have privileged information that you don't that has led him to an understand that one runner is more likely to win than the other. In a deterministic universe such information must exist. You can get out of this by saying that you know it's impossible for anyone to gather or analyise that information, of course. In which case, if you can be certain that no one can have more information about the outcome of the race than you already have, you should necessarily accept that favourable bet in scenario 1.
Now let's look at scenario 2. Again, if the person making the bet against you has information about the race's competitors, conditions, etc. that you don't have, making the bet might be a bad idea. If you can be certain that the other party doesn't have information that you don't have, again you should accept the bet.
Why?
Let's look at it this way. Someone offers you favourable odds. You've never heard of these runners, but then neither has he. You decide, ah, I'll flip a coin, heads I take the bet, tails I don't.
Here are the possible outcomes:
You take the bet and win - C
You take the bet and lose - I
You don't take the bet, but would have won - I
You don't take the bet, but would have lost. - C
In 50% of these outcomes, you made the right decision (denoted with a C). In 50% of them you made the wrong decision (denoted with an I).
In those outcomes where you made the right decision and won, your winnings were greater than your losings in those outcomes where you made the wrong decision and lost. But these outcomes are both equally common.
You point out that this is only true when the other party has no information that you don't have. But the same is true of both scenario 1 and 2, and so can't be used to distinguish between them, except in so much as you have more reason to suspect that the other party might have more information than you in scenario 2 than in scenario 1.