Elind
Philosopher
Nope. I am assuming that it's going to be isolated and in a hostile environment. The first is given, considering the fact that we're talking about some sort of vessel--for the purposes of replenishing supplies, ALL vessels are isolated. Even cars need to stop at gas stations. The second is given, considering the fac that space is dangerous. Look at what happens when a grain of sand traveling at a significant percentage of c hits something; NO ship can just laugh off a hit like that. xkcd did a neat "What If" on this topic using baseballs; the result was equivalent to a nuclear bomb. And that's just one hazard; any one of a billion different things can go wrong, necessitating repairs on a timescale from "when you get around to it" to "we're all dead if you don't fix it now".
ANYTHING that has those issues to contend with will NECESSARILY have to find some celestial body to harvest for resources to repair itself. If you wish to disagree with me, those are the points you need to disprove. Dismissing them, as has been your MO in thread, doesn't make them go away.
This will still require energy. Earthly cycles are driven by nuclear energy in the planet's interior and solar energy from the exterior. Without those, we'd have no cycles at all--there wouldn't be sufficient energy. What this means is that SOMETHING is being used up, and will eventually run out. Furthermore, even the largest ship cannot carry an infinite number of replacement parts; I've yet to hear of anything that can carry even sufficient replacement parts to duplicate itself. Which means that unless you are postulating as-yet unknown technology (ie, magical thinking), you've got to account for damage and repairs.
We started with the presumption that beings could cross between stars, over hundreds if not thousands of years and you think the sizes and technologies are NASA 2015.
This is getting silly.