Chris_Halkides
Penultimate Amazing
- Joined
- Dec 8, 2009
- Messages
- 13,011
Novelli's ill-conceived analogy concerning analysis of one or two cells of DNA
In arguing for further testing of the knife in 2011 Professor Novelli said that they routinely studied 1-2 cells' worth of DNA in his laboratory. The CSC wrote in 2013, "Novelli, geneticist of undisputable fame recognized by the same Court (p. 79 sent.) on the availability of equipment able of operate with safety also quantities of less than ten picograms, in the areas of diagnostic character (even on embryos) in which the claim to certainty is certainly no less pressing than that which animates the legal field, the Court rejected that proposal, assuming that the methods to which Prof. Novelli had referred were "in the experimental phase” (p. 84 sent.), thus freely interpreting and misrepresenting the assumption of bias, which in fact was to remember the use of these diagnostic methods in areas in which you can be certain of the result."
Angela von Daal wrote, "The use of PCR for analysis of very low levels of DNA in the field of pre-implantation genetic diagnosis (PGD) has been used to justify general acceptance of LCN analysis in the wider scientific community(12) . This argument is flawed. PGD analysis is not analogous to LCN analysis for several reasons. PGD uses pristine cellular DNA from a single source, whereas forensic LCN samples are mostly mixtures and are likely in a state of apoptosis. The complexities of profile interpretation issues seen with STR analysis (e.g., stutter) are not an issue for PGD testing(13) . However the most significant difference is that the samples derived from the mother, father and embryo are single-source and the parental samples are of known genotype." (highlighting mine)
Reference 12 is People v. Hemant Megnath, 2010 N.Y. Slip Op 20037; 2010 N.Y. Misc. Lexis 223.
In arguing for further testing of the knife in 2011 Professor Novelli said that they routinely studied 1-2 cells' worth of DNA in his laboratory. The CSC wrote in 2013, "Novelli, geneticist of undisputable fame recognized by the same Court (p. 79 sent.) on the availability of equipment able of operate with safety also quantities of less than ten picograms, in the areas of diagnostic character (even on embryos) in which the claim to certainty is certainly no less pressing than that which animates the legal field, the Court rejected that proposal, assuming that the methods to which Prof. Novelli had referred were "in the experimental phase” (p. 84 sent.), thus freely interpreting and misrepresenting the assumption of bias, which in fact was to remember the use of these diagnostic methods in areas in which you can be certain of the result."
Angela von Daal wrote, "The use of PCR for analysis of very low levels of DNA in the field of pre-implantation genetic diagnosis (PGD) has been used to justify general acceptance of LCN analysis in the wider scientific community(12) . This argument is flawed. PGD analysis is not analogous to LCN analysis for several reasons. PGD uses pristine cellular DNA from a single source, whereas forensic LCN samples are mostly mixtures and are likely in a state of apoptosis. The complexities of profile interpretation issues seen with STR analysis (e.g., stutter) are not an issue for PGD testing(13) . However the most significant difference is that the samples derived from the mother, father and embryo are single-source and the parental samples are of known genotype." (highlighting mine)
Reference 12 is People v. Hemant Megnath, 2010 N.Y. Slip Op 20037; 2010 N.Y. Misc. Lexis 223.