Brilliant Tatyana, an excellent clarification of flu and vaccination, many thanks. Ashamed to say I'd never heard of a 'cytokine storm' (I think the immune system had only just been invented when I was at college

).
If the cytokine storm is caused by the immune response to flu infection why/how is it that vaccination helps improve this - why does the immune system react without the storm after vaccination?
Yuri
We don't get the cytokine storm as the amount of antigen that we are given is just so small it really is just an epitope.
This is also the reason why adjuvents are in vaccines, as we need to enhance the immune response to the antigen to ensure that we do create memory cells.
The immune response to a vaccination can be cytokine ladened, and it often makes people feel like they have a mild flu, especially the first time they have the vaccine (as I did).
People mistake their own immune system's cytokine response from being immunised for being ill, because basically, it is our immune system that is creating all of the symptoms we associate with having a cold or flu for the most part.
If you have had one of those awful 'I felt like crap after having my flu jab', then you are an individual who is a candidate for the deadly cytokine storm if you encounter a new wild type influenza A virus.
If you felt that crap 'I caught the flu from the jab' from a tiny, tiny, tiny dose of the virus, a rapidly replicating, aggressive and novel virus is really going to cause your immune system to flip out.
Anecdotally, I have had so many flu jabs that now my arm doesn't even get sore, I have to press on the injection site to notice any sort of side effects.
This is the other issue people bring up, that the vaccine has to match the flu for that season.
Yes, this is true, but if you have had previous immunisation, and there are only something like 16 H (haemogglutinin) and 9 N (neuromidinase) spikes on influenza A that affect humans, and every year there are typically three strains of virus in the jab.
So even if the next global pandemic is something like H5N9, my memory cell from previous bird flu jabs would still recognise the H5 spike and start mounting the more effective antibody response to that spike.
Just for those of you who are unaware of this, IT IS STILL YOUR IMMUNE SYSTEM THAT DEALS WITH THE INFECTION YOU ARE INFECTED WITH, it isn't like the vaccine is a 'magic stop infection bullet', it just gives your immune system a jump start.
For example, I am fairly positive I still caught the flu last year, however, it was very short lived and not nearly as miserable and morbid as the previous flu(s) I have had.
A vaccine will not STOP infection, if there is some nasty bacteria or virus floating around in your environment, you are still as likely to catch it, however, if and/or when you catch the pathogen, YOUR IMMUNE SYSTEM WILL DEAL WITH IT IN A MORE EFFECTIVE AND TIMELY MANNER.
This is why the whole argument that 'vaccines weaken our immune system' is just utter rubbish and using it make you look like a science retard.
The immune system does EXACTLY the same thing, goes through EXACTLY the same set of stages if you are exposed to the vaccine pathogen or the pathogen in the wild.