There are facts to be known about the universe. If we organize those facts in terms of the the movement and constituents of objects, we get Physics.. If we organize those facts in terms of life, we get Biology. We can take the body of facts about the functioning of the human body and get Medicine.
if we map those facts in terms of death, disability, disease, discomfort and dissatisfaction we discover that there are different positions that individuals and groups occupy on that map. Furthermore, if you map those facts in terms of the presence and absence of the 5 D's, you have a landscape of positions which can be occupied. We call that 'health' now, but in the past* 'health' referred to a different map which was organized in terms of facts about religious beliefs or superstitions or a variety of other characteristics.
As Harris points out, there is also a body of facts about the brain states of conscious creatures. And if we map those facts in terms of specific kinds of brain states, like pleasure, pain, satisfaction, autonomy, security, etc., there are different positions to occupy on this map. In general, this can be called a map of 'well-being'. Like 'health', there is a directionality to these factors, such that a position can be higher or lower on a landscape. Which factors are part of our map are those whose alteration leads to change in position on our map (not as circular as it appears

). For example, including the factor "eye-colour" would not alter a position up or down, including "boredom" would alter it a small amount, and including "physiological stress" would alter it a large amount.
Just like it is practically impossible to form a map of 'health', or a map of Biology or a map of Anthropology, it would be practically impossible to form a map of 'well-being'. But just like 'health', it is possible to discover facts relevent to the positions occupied on the landscape, like drugs which move positions up towards the absence of disease.
What Harris asks of you, when speaking about which actions humans should perform, is that reference is made to a body of facts. If you think that the body of facts should be formed a bit differently, this is something which can be approached empirically (i.e. the actual form of the body of facts does not need to be assumed). And he asks that preference can be shown for one direction. He asks that preference can be shown towards the direction of decreased suffering rather than increased suffering. That's all. And in the second talk that Paulhoff referenced, he points out that it is a far more obvious and easy thing to ask that decreased suffering is preferred to increased suffering, than to ask for us to prefer parsimony. That is, he stands on much firmer ground asking individuals if they prefer being hit on the head with a hammer, than if he asks them to forego belief in a creator (in reference to parsimony).
So we have a body of facts which in subsumed under the general title of well-being of conscious creatures. What should we call it? Well, we have something called 'morality'. It refers to something else, but there is some overlap in the kinds of facts which inform both. Why don't we use that name?
Well, look at what happens. There is a lot of baggage associated with the term 'morality', and that baggage gets transferred to our body of facts, without it being of any relevance. For example, there is something called an "is/ought problem" associated with morality which has nothing to do with our body of facts. Maybe we'd better call it something else, or we'll end up arguing about utility values for each position on the map, or what the definition of "is" is.
Oops. Too late.
Linda