The appeals trial process will differ in many ways from the first trial. Only the makeup of the court -- six lay jurors and two professional judges -- remains the same. It will likely proceed much faster because the court is mostly debating Judge Massei's judgment, not rehearing witnesses or re-examining evidence, though the court can specifically request to rehear key witnesses and the Knox and Sollecito defense teams have filed requests for an independent evaluation of certain pieces of contested evidence.
On appeal, the case is once again wide open, as the court could do anything from giving Knox a harsher life-in-prison sentence to turning over her conviction.
"The court can review all the same evidence presented in the first trial, but simply decide that there is reasonable doubt, that they don't believe it," explained University of Parma criminal procedure professor Stefano Maffei.
The court also can agree with prosecutors, who are also appealing the 26-year-sentence and asking for life, and give her even more prison time. Or, the court can agree with the murder conviction, but find that mitigating factors outweigh the aggravated ones, which leads to a one-third reduction in sentence. That is a most likely scenario, court observers such as Maffei say, especially since more than 18 Italian magistrates have reviewed the evidence in the Knox case and come to the same conclusion of culpability, which somehow ingrains the decision into the judiciary. For reasons that are sociological rather than legal -- such as good behavior, political pressure, changed public opinion or prison crowding -- sentences in Italy are often reduced on appeal.
"The tradition in this country remains that the court of appeal is usually more lenient than the court of first instance," Maffei said.