So, by my reckoning, over just the past six weeks or so, this thread has been able to make significant headway into the following areas:
1) The front door situation (it appears that keys were needed to open the door even from the inside, and that the door needed to be locked with the key since the latch had been disabled)
2) The problems with LCN DNA analysis, as it applies to both the knife and the bra clasp (Stefanoni was pushing for particular (and known) results in a lab with insufficient LCN ant-contamination measures, no control samples, and seemingly no accreditation)
3) The injuries (or lack thereof) to Knox (implying that the so-called "mixed-DNA" evidence from the bathroom is worthless, since there appears to be no evidence that Knox bled from any struggle-related contact)
4) The shoeprint evidence in the murder room (shown to very likely to be exclusively made by Guede's tennis shoe, thereby removing another piece of evidence placing Knox in the room at the time of the crime)
5) The testimony of both Quintavalle and Curatolo (so many inconsistencies, confusion over dates, conflict with others, length of time before "remembering", assistance in coming forward from journalists)
6) The timing of the 2 November phone calls (almost certainly made before the postal police showed up, negating a prosecution argument that they were made when the police were already in the house as some sort of alibi-creation strategy)
7) The movements and activities of Meredith's cellphones on the night of 1 November (the aborted call home just before 21.00 followed by the fact that she never tried to call again, the strange and out-of-character terminated calls to her UK voicemail and her UK bank, the registration at around 22.15 of the cellphones with cell masts situated on the route to where the phones were dumped)
8) The reasoned interpretation of the autopsy report (Meredith still had undigested pizza from an 18.00-18.30 meal in her stomach, heavily implying that death occurred within 2-3 hours of this meal - i.e. before 21.30 at the latest)
9) A reasoned discussion of hard drug usage (either the pair were not habitual users of any controlled substance other than cannabis, or they were hard-drug users and the police failed to find evidence of it in their investigation)
10) Plenty of documented evidence supporting the position that Knox may have been coerced and bullied into supplying a false confession/allegation
11) A reasoned discussion of Guede's possible level of sole participation (how and why Guede might have had the motive, means and opportunity to enter the house alone, how and why his faeces ended up unflushed in the toilet, how and why he might have searched for Meredith's keys in order to be able to exit the house via the front door rather than via the window, how and why he might have simply pulled the front door shut behind him, rather than stopping to lock it).
And I'm pretty sure there are more areas than these - they just don't spring to mind right now. Pretty good going, though, for a thread that many others wish to see either shut down or wither and die. To my mind, there's only one place right now where a serious and intelligent debate is taking place about this crime.