2000s
* November 22, 2000 - Jamal Abdel Raziq, senior official of the Fatah faction Tanzim, is killed with his driver, Awni Dhuheir, when their car is fired upon by IDF troops in Gaza. The IDF troops also killed two innocent bystanders in the car in front of Abdel Raziq -- Sami Abu Laban, 29, a baker, and Na'el Al Leddawi, 22, a student -- in the attack.[6][7]
* February 3, 2001 - Massoud Ayyad, a lieutenant-colonel in Yaser Arafat's Force 17, is killed while driving in the Jabaliya refugee camp in Gaza by three helicopter launched rockets.[8]
* July 31, 2001 - Jamal Mansour, a high ranking official of Hamas' West Bank political wing, is killed when his office is struck by helicopter launched missiles.[9]
* August 20, 2001 - Imad Abu Sneneh, the leader of Tanzim, is shot and killed in Hebron by an Israeli team.[10]
* January 14, 2002 - Raed al-Karmi, head of al-Aqsa Martyrs' Brigades assassinated in Tulkarem.
* July 22, 2002 - Salah Shahade, the leader of Hamas Izz ad-Din al-Qassam Brigades is killed using 2,205 pound of explosive dropped by a F-16. The attack also killed his wife and 9 children.
* March 8, 2003 - Ibrahim al-Makadmeh and three of his aides were killed by helicopter-fired missiles Gaza City
* August 21, 2003 - Ismail Abu Shanab - high ranking Hamas official [11]
* March 22, 2004 - Ahmed Yassin, co-founder and leader of Hamas, and bodyguards are killed in the Gaza Strip when hit by Israeli Air Force AH-64 Apache fired Hellfire missiles.
* April 17, 2004 - Abdel Aziz al-Rantissi, co-founder and leader of Hamas and successor of Ahmed Yassin as leader of Hamas after his death, is killed by helicopter-fired missiles along with his son.
* October 21, 2004 - Adnan al-Ghoul, Hamas weapons expert, and Imad Abbas were killed when an Apache helicopter fired missiles at their car.
* May 25, 2006 - Mahmoud al-Majzoub, a commander of the Palestinian Islamic Jihad, was injured in a car bombing in Sidon, Lebanon and died the next day. Islamic Jihad blamed Israel, though Israel denied it.
* June 8, 2006 - Jamal Abu Samhadana was killed by an Israeli airstrike along with at least three other PRC members.[12][13]
* January 16, 2008 - Walid Obeidi, commander of Islamic Jihad's al-Quds Brigade is gunned down by Israeli commandos in the West Bank town of Qabatiya.[14]
* February 12, 2008 - Imad Mughniyah, one of Hezbollah's top commanders, was assassinated by a car bomb in Damascus, Syria. Some news reports indicated the Mossad was responsible,[15] though Israel denied carrying it out.[16].
* August 1, 2008 - Muhammad Suleiman, a Syrian General and top liaison between Syria and Hezbollah, is killed by sniper fire. Israel never takes credit for the killing but is widely suspected.[17][18]
* December 16, 2008 - Jihad Nawahda, a top Islamic Jihad commander, is ambushed and killed by undercover Israeli troops as he enters an internet cafe in the West Bank city of Jenin.[19]
* December 27, 2008 - Tawfiq Jabber, the commander of Hamas' police force in Gaza; Ismail al-Ja'abri, commander of the defense and security directorate; and Abu-Ahmad Ashur, Hamas' Gaza central district governor are all among the Hamas dead in the opening strike of Operation Cast Lead.[20]
* January 1, 2009 - Nizar Rayan, one of the top Hamas military commanders and decision makers, is assassinated in an Israeli air strike, along with his four wives and eleven of their children. He is the most senior Hamas member to be killed since 2004.
* January 3, 2009 - Abu Zakaria al-Jamal, a senior Hamas commander, is killed in an Israeli air strike.[21]
* January 15, 2009 - Said Seyam, the Hamas Interior Minister, is killed in an Israeli air strike that also claimed his brother, his son, and Hamas general security services commander Salah Abu Shrakh.[22]
* March 5, 2009 - Khaled Shalan, a senior member of Islamic Jihad, is killed in an Israeli air strike as retaliation for Palestinian rocket attacks on the Israeli city of Ashkelon.[23]
* May 28, 2009 - Abdel-Majid Uddin, a major Hamas commander in the West Bank, is killed during a raid conducted by the Israeli Special Forces unit YAMAM.[24]
* Others.[25]