Twat - at least in the UK - has long passed being an inherently sexual slur. It means an unpleasant person.
ETA:If that is the Kathy Burke I think it is, she was being very restrained in her language!
I'm not sure that it is as this one insists that she is the one with the, "good hair" and that, "her snowflake brings all the ***** to the yard". The asterix'd word being a curse word for the female anatomy often used as an epithet.