Thing is - and Darat mentioned this and you dismissed it - we actually do know an awful lot about the way the universe works. We know that there are only four fundamental ways in which particles can interact. Of the four, only two are capable of acting at greater than subatomic distances - gravity and electromagnetism. There are literally no other ways for particles (ie, stuff) to interact, and we know this for a fact. A century of experimentation and mathematical rigour have led us to this conclusion.
Furthermore, we know very precisely when and how these forces work. Very precisely indeed. For the electromagnetic force, we know how it operates more precisely than we have ever known anything else.
What you're proposing, though you don't even realise it, is the existence of some method for stuff to interact with other stuff that has previously gone unnoticed. Given the precision and accuracy with which we know the existing methods of stuff to interact, it is pretty much inconceivable that there exists another method that we have been unable to pin down with equal accuracy and precision.
We're very good at discovering how things work. That we haven't discovered yet how telepathy works - or even that telepathy works - very strongly suggests that there is no phenomenon there to discover.
The gap in our knowledge in which telepathy might be able to fit is extremely small.