Planigale, since you have been party to the debate in which you suggested size of meal should be considered with TOD, how do you see this link I posted today in that context?
Here is another paper, that discusses gastric emptying for pre op, but addresses another issue that has been raised, size of meal.
In contrast, the gastric emptying curve for solids is linear20,21 (Fig. 2). Gastric emptying of solid food starts approximately 1 h after a meal. Within 2 h, approximately 50% of the solid food ingested is passed to the duodenum. The gastric emptying of solids is independent of the amount of food ingested but dependent on the caloric density of the meal.
http://www.scielo.org.co/scielo.php?...72007000400004
I am quite unable to find any research that allows for Meredith's autopsy to be consistent with a meal anywhere near two hours before her death, yet one hour to 90 minutes seems correct.
Obviously I am interested in your take as a scientist.
This is important material.
The longer from the time of the meal the more likely it is that gastric emptying will have been initiated. The corollary is that ToD gets progressively less likely.
The papers are all laboratory tests. Do not take the figures too literally. Different methodology gives different results. Different definitions are used; T lag does not measure time to first gastric emptying but usually to a small but definite emptying e.g. 10% of test meal. The tests are more precise (giving reproducible values) than accurate. A doctor does not need to know if normal gastric emptying is 30 or 45 minutes. What is needed is a measure that maps to gastric emptying, can separate abnormal gastric emptying from normal, and shows improvement with treatment (or not). None of these values are strictly applicable to hungover 20 yr olds probably with cannabinoids in the blood, who have had a late night, and eaten pizza and apple crumble (for instance if you use an oat topping as I do, oats delay gastric emptying). I suspect the normal value for gastric emptying is prolonged as compared with these papers, but probably only by about 40 minutes in terms of median values, this will be reflected in a shift of the upper limit. My value of 40 minutes is from looking at the range of values that interventions or drugs have on gastric emptying. In contrast despite what some argue there is little evidence that psychological stress has much impact on gastric emptying, so the argument that in some way MK was tortured by AK and RS from 21.00 but not killed until 23.00 is scientific nonsense.
What we can take from this is a ball park figure, an upper limit. Some people argue the published time to gastric emptying is incompatible with the time of the meal, and a death after 21.00 and therefore the gastric / duodenal contents evidence should be ignored. In fact I think this actually makes it more useful since we know we are near the upper limit of time to gastric emptying in a real world situation; I think ToD was between 21.00 and 21.30. This fits with the one eye witness RG, and telephone data.
The important thing is that there are several circumstantial pieces of evidence that support one another.