I have 2 monitors on a 4870 and no problems at all ..
I tried to Google problems with ATI and 4 monitors, and did not come up with any pattern of there being problems with such a set up ..
I would think if ATI had pervasive driver issues, the word would be out ...
Are you using the ATI Hydravision utility, or just the Windows display manager ?
Was this a clean install, or was there another video set up running before you installed the two ATI cards ?
How do you know quad monitors running on 2 x NVIDIA cards would not present similar problems for you ?
It was a clean install on a bare drive using Win7 Enterprise. No video card other than the 4870 was ever installed. Using Hydravision and Catalyst control center for the rotate display option to get the 2 monitors set to portrait. And it's a single-card 4870 x2, not 2 separate 4870s. I haven't tried running quad monitors off of an Nvidia card, is there a 4xDVI version of an Nvidia?