The Callahan's Place stories went down the drain, for me, when Spider decided saving individual people wasn't exciting enough -- he had to have his characters save the world.
The universe this time.
And honestly, I really could have lived without the scene where Jake's fourteen-month-old supergenius daughter reacts to a compliment with "Why, Uncle Nicky, what a sweet thing to say! I'm going to start f***ing when I'm sixteen, would you like to take a number? I can fit you into the single digits if you hurry."
Yeah, that line nearly made me stop reading - and I almost never abandon a book once I start it! It wasn't just the squick factor (I'm pretty tough to shock), it was the "Look at me, I'm being really casual about sex! Aren't I just the biggest little rebel you've ever read?!?!" factor.