I disagree my-wan, although I understand your intuition. As HawaiiBigSis said "above all" is a parenthetical remark. Using the rule that you should be able to remove anything between two commas and still have a sentence that reads correctly:
"Several friends have provided me with inspiration: Tim, Ian and, above all, Larry."
Becomes:
"Several friends have provided me with inspiration: Tim, Ian and Larry."
Whereas
"Several friends have provided me with inspiration: Tim, Ian, and above all, Larry."
Becomes:
"Several friends have provided me with inspiration: Tim, Ian, Larry."
Which doesn't really read properly (at least to me).
A comma before every "and" doesn't seem necessary, unless it's separating completely separate ideas (clauses?), since, as you say, the joining word is a pause in itself. Putting a comma before "and" in a list (the Oxford comma) seems unecessary to me but it can help to make things clearer e.g., "Comedy legends Cooper, Izzard, and Morcambe and Wise."
What really bugs me is the habit of newspaper headline writers to completely replace an "and" with a comma. It seems to be more common in the USA than the UK, but I have seen it here once or twice. A trivial example from the onion is:
"Affluent White Man Enjoys, Causes The Blues"
What?! Where's the "and", it's just so ugly and it doesn't flow that my brain simply cannot read something like that without rebelling.