Six Reason to Question Vaccinations

The sarcasm isn't necessary.
No, it's not. Of course, it wasn't necessary when anyone else in this thread used it either. I wasn't the one who brought up piracy and global warming in this thread as an example of how meaningless correlations can be. But their behavior doesn't excuse mine and you certainly didn't deserve it. I apologize.

Of course we think that measles vaccination may have an impact on child mortality rates. The complaint is directed at the way in which you chose to answer the question, not the actual question.

Linda

That's not how I read the posts. So now that I've capitulated and agreed that the correlation may be meaningless, you want to say that it isn't? That high vaccination rates might just maybe be a factor in a lower child mortality rate? That's all I was trying to say. I don't know why it generated such controversy.

Is there any meaning to the correlation? I don't know. I never meant to imply that I did. Everyone just assumed it. I never did. I only assumed that it was possible they were related and a strong correlation gives some credence to that hypothesis. Doesn't prove it, but it is evidence. However, I'm tired of arguing it. You can argue with Skeptigirl and JJM and the rest about whether or not the correlation means anything.
 
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A pharmaceutical company has come up with a vaccine for the common cold. It has been shown to be 90%+ effective in large scale trials performed over many years. I.e. we know it works well. You need to be vaccinated every year for the vaccine to be effective.

How much would you be prepared to pay for it?
 
I've been trying to find out how lethal the common cold is, without much success. Most developed countries appear to list 1 death per year caused by the common cold. But this seems odd because the countries have widely varying populations (e.g., UK & USA).

So I'm thinking the cause of premature death is being recorded as something else, such as an underlying medical condition, or the resulting complications caused by the cold.

Does anybody have any reliable estimates for the number of people the common cold kills each year, including complications and underlying medical conditions?

BTW, it's estimated the population of the USA have 1 billion colds per year!
 
I was attempting to clarify why we say there is no relationship even if a statistically significant correlation co-efficient can be obtained.

It's not because we know in advance whether or not a relationship exists (else why do the test?).

It's not because the relationship sounds silly. Pirates and global warming, Nikes and child mortality sound absurd, but vaccination rates and child mortality does not.

It's not because group data cannot be used for analysis. Although, in this case, group data cannot be used to support the relationship that Beth claimed (increase in vaccines are associated with a decrease in child mortality) because it provides insufficient detail.

It's not because the relationship is indirect. Although, the more indirect the relationship, the sillier it becomes to label it as a relationship.

It's because she took a systematic bias and called it a relationship. Usually we attempt to remove bias, rather than celebrate it.

ETA: I should also clarify that your post was drawing attention to the possible lack of a statistically signification correlation coefficient depending on what/how the data is used (which is another good reason not to call it a relationship. ;)).

Linda
Got it.

Yes, that's pretty much getting at the issues here.
 
I'm sorry. If you'll look in the upper right hand corner of that page, there are drop down menus allowing you to select from many different statistics. You can get all of the ones I referenced through that cite.
I looked at the drop down menus. I found nothing there about child mortality from birth to age 5 nor anything resembling the annual figures you used. I assume I am looking at your citations from the wrong post. Since you weren't clear which site you were referring to and I can't find the numbers on the site you linked to that I looked at, just re-post the link to the numbers. If I still can't find them, I'll let you know.
Sorry you didn't care for my selection of statistics. Feel free to do your own analysis using whatever statistics you think are relevant.
I did. Did you miss that in my post? It completely contradicted your graph.

Clearly, the relationship between the variables of measles vaccinations and under 5 mortality rates is no more meaningful than the relationship between global warming and piracy. It's ridiculous to think that measles vaccinations rates have any impact on child mortality rates. I'm sorry if I offended anyone by implying that it might just because they are strongly inversely correlated in the recent history of some countries. :rolleyes:
I believe this is referred to as a straw man. :rolleyes:

No one is arguing this at all Beth. Get you head out of the sand and read what we are actually faulting you on.
 
... So now that I've capitulated and agreed that the correlation may be meaningless, you want to say that it isn't? That high vaccination rates might just maybe be a factor in a lower child mortality rate? That's all I was trying to say. I don't know why it generated such controversy.

Is there any meaning to the correlation? I don't know. I never meant to imply that I did. Everyone just assumed it. I never did. I only assumed that it was possible they were related and a strong correlation gives some credence to that hypothesis. Doesn't prove it, but it is evidence. However, I'm tired of arguing it. You can argue with Skeptigirl and JJM and the rest about whether or not the correlation means anything.
She believes, she doesn't believe, she believes, she doesn't believe....

I believe the adjective, "strong" was not correctly applied to your data analysis. I believe this is why your claims generated the response it did.
 
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I've been trying to find out how lethal the common cold is, without much success. Most developed countries appear to list 1 death per year caused by the common cold. But this seems odd because the countries have widely varying populations (e.g., UK & USA).

So I'm thinking the cause of premature death is being recorded as something else, such as an underlying medical condition, or the resulting complications caused by the cold.

Does anybody have any reliable estimates for the number of people the common cold kills each year, including complications and underlying medical conditions?

BTW, it's estimated the population of the USA have 1 billion colds per year!
Ivor, are you aware there is no specific agent designated when one refers to "the common cold"? The label implies a mild upper respiratory infection. There are over 200 known organisms which cause mild upper respiratory infections. The problem with your logic here is many of those organisms also cause serious morbidity and mortality. For example, the corona virus causes SARS but it also causes illnesses which would be considered the "common cold". Adenoviruses as well can cause a mild sore throat or fatalities depending on the genetic makeup. I imagine the one family of viruses most likely to be mild are the rhinoviruses.

Rhinoviruses
RHINOVIRUS DISEASE

*

There are nearly 62 million cases of the common cold annually in the US
*

52.2 million of these cases affect Americans under age 17
*

There are nearly 22 million school-loss days annually due to the common cold
*

There are approximately 45 million bed days annually associated with the common cold
*

Seventy-five percent of common colds suffered by children under 5 years are medically attended
Source: Vital and Health Statistics Series 10, No. 200
Very few fatalities are associated with rhinoviruses. A vaccine against rhinoviruses isn't possible today since there are over 100 versions. If there were a vaccine, the benefit would be in preventing morbidity, not mortality. I imagine a lot of people would love a vaccine that prevented the mild but annoying symptoms of the more common upper respiratory infections.

BTW, 62 million is a bit short of a billion. Do you ever post citations for your data or do you just make stuff up?
 
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The economic burden of non-influenza-related viral respiratory tract infection in the United States.
Fendrick AM; Monto AS; Nightengale B; Sarnes M
Arch Intern Med. 2003 Feb 24;163(4):487-94.

(Extrapolation from phone survey - therefore possible selection bias)

RESULTS: Of survey respondents, 72% reported a non-influenza-related VRTI within the past year. Respondents who experienced a self-reported non-influenza-related VRTI averaged 2.5 episodes annually. When these rates are extrapolated to the entire US population, approximately 500 million non-influenza-related VRTI episodes occur per year.


ETA also check this if you can:
The common cold
Heikkinen T; Jarvinen A
Lancet 2003 Jan 4;361(9351):51-9.
 
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Ivor, are you aware there is no specific agent designated when one refers to "the common cold"?

Yes.

<snip>

BTW, 62 million is a bit short of a billion. Do you ever post citations for your data or do you just make stuff up?

Here you go:

http://www3.niaid.nih.gov/healthscience/healthtopics/colds/overview.htm

In the course of a year, people in the United States suffer 1 billion colds, according to some estimates.

What stuff that I've posted do you think I'm "making up"? If you give me specifics I'll do my best to find the source, or come clean and admit I appear to have imagined it.
 
Does anybody have any reliable estimates for the number of people the common cold kills each year, including complications and underlying medical conditions?
Bit like the flu scenario - colds can lead to other fatal complications, such as asthma attacks, which can certainly be lethal. It is thought up to 40% of attacks are precipitated by an URTI. I'll try an dig out refs later. Work to do.
 
.....


What stuff that I've posted do you think I'm "making up"? If you give me specifics I'll do my best to find the source, or come clean and admit I appear to have imagined it.
I was specific. And you rarely post sources for your claims.

Just a side note, now that I see the source of Ivor's data:

Deetee's source cites the source of the data as does mine. Her's is the most direct. In order to check on my source one has to take the next step and see where the cited source got the figure. Your source, Ivor, is a general reference in a source but doesn't say where the data is from. You couldn't find the source of the data if you wanted to.

Clearly the estimates vary widely and it isn't very relevant to this discussion. My point was merely that it helps to know where someone is getting their data from so the reader can judge the validity for themselves. I can't judge the validity of the "billion colds" from the NIH source anymore than before Ivor cited it. One might rely on the 'authority' of the NIH, and it is sufficient for this conversation. But were we discussing something where the number mattered, a casual reference in such an article as the NIH one is really not adequate.

Again, for this discussion, it is adequate. But it still remains important to post where one's information is coming from.
 
Skeptigirl said:
I was specific. And you rarely post sources for your claims.

Care to provide source(s) for your claim that I rarely post sources for my claims?:)

Or is this just a blatant attempt to attack the arguer, rather than the argument?
 
Review this thread, Ivor. There are 13 pages here and you've posted quite a bit. Copy the links you've posted here and see what they amount to.
 
Review this thread, Ivor. There are 13 pages here and you've posted quite a bit. Copy the links you've posted here and see what they amount to.

Here we go:

http://books.nap.edu/openbook.php?record_id=4772&page=237
http://www.livescience.com/environment/050106_odds_of_dying.html
http://www.meningitis.org/disease-info/whats-the-risk
http://news.scotsman.com/health.cfm?id=1772922007
http://www.healthsentinel.com/graphs.php?id=54&event=graphs_print_list_item
http://news.bbc.co.uk/1/hi/magazine/4829628.stm
http://www.nationalwatersafety.org.uk/watersafetyathome/gardenponds.htm
http://www.bbc.co.uk/radio4/science/casenotes_tr_20061003.shtml
http://www.immunize.cpha.ca/english/consumer/consrese/pdf/93_2_114-16.pdf
http://adc.bmj.com/cgi/reprint/88/10/862
http://www.ohe.org/page/knowledge/schools.cfm
http://www.immunisation.org.uk/files/275877_Catch-upleaflet.pdf
http://adc.bmj.com/cgi/content/full/88/10/859
http://www.netdoctor.co.uk/diseases/...hepatitisa.htm
http://www.traveldoctor.co.uk/malaria.htm
http://www.ncbi.nlm.nih.gov/sites/en...t=AbstractPlus
http://www.ncbi.nlm.nih.gov/sites/en...RVAbstractPlus
http://www.advisorybodies.doh.gov.uk/jcvi/mins20jun07.htm
http://www.jr2.ox.ac.uk/bandolier/painres/download/whatis/ImplementQALYs.pdf
http://en.wikipedia.org/wiki/Flying_Spaghetti_Monster
http://www.mchb.hrsa.gov/chusa_06/
http://www.mchb.hrsa.gov/chusa_06/healthstat/infants/graphs/0306im.htm
http://www.mchb.hrsa.gov/chusa_06/healthstat/children/graphs/0315cm.htm
http://www.mchb.hrsa.gov/chusa_06/healthstat/children/graphs/0311vpd.htm
http://www.ncbi.nlm.nih.gov/sites/en...RVAbstractPlus
http://hyperphysics.phy-astr.gsu.edu/hbase/seatb2.html
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=pubmed&dopt=AbstractPlus&list_uids=2319551
http://www.ncbi.nlm.nih.gov/sites/e...med.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
http://www.ncbi.nlm.nih.gov/sites/e...med.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus
http://en.wikipedia.org/wiki/Infant_car_seat
http://www.nhtsa.dot.gov/people/injury/research/SafetySurvey/Chapter2.html
http://www.statistics.gov.uk/cci/nugget.asp?id=1208
http://www.nationmaster.com/graph/mor_acu_nas_com_col-mortality-acute-nasopharyngitis-common-cold

That's most of them, I think. Many of my posts also refer to links provided by others in their posts. I have not included these.
 
Skeptigirl, let's not get to insistent on sources for every comment made in the forums. Ivor made a remark in passing about the burden of colds in the USA; his source may not have been a specific scientific publication, but his link to the NIAID claim for this should suffice as reasonable evidence for his statement in the context of the discussion.
When a claim about something is strongly disputed, then the protagonists can put forward the case for the veracity of their respective claims, but I don't think a disagreement about how many people get colds should be a reason for two of my favourite posters to fall out.
:)
 
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Skeptigirl, let's not get to insistent on sources for every comment made in the forums. Ivor made a remark in passing about the burden of colds in the USA; his source may not have been a specific scientific publication, but his link to the NIAID claim for this should suffice as reasonable evidence for his statement in the context of the discussion.
When a claim about something is strongly disputed, then the protagonists can put forward the case for the veracity of their respective claims, but I don't think a disagreement about how many people get colds should be a reason for two of my favourite posters to fall out.
:)
I was tired of Ivor's unsubstantiated claims for good reason. I made a point of saying that particular unsubstantiated claim was minor. But since you and Ivor insist on defending his frequently unsubstantiated claims, then so be it. I am only going to review one page of Ivor's unsubstantiated claims. I have been in discussion after discussion with him and know he makes unsupported claim after claim.


One need only examine page one in this thread to reveal the pattern.

post 30
The way vaccination is sold to individuals at the moment is often by misleading them into thinking being vaccinated will protect them directly by a significant amount.

It displays a certain level of contempt for people to think they are too selfish and/or stupid to be persuaded by an honest argument for vaccination, which would highlight the benefits to the community over the individual.
False claims, no sources.

post 33
If only one person has been vaccinated in a population, anything less than 100% immunity merely extends the expected time before they get infected.

Realistically, vaccination only "works" if enough of the population get vaccinated. The lower the efficacy of the vaccine, the more people in the population need to be vaccinated for it to have a significant effect.

Then there are those vaccines that are pretty useless for prevention, such as the BCG, though supposedly this does reduce the risk of complications if you do contract TB.
False claims, no sources.

post 35
That's why I put "works" in quotes. This page explains what I was thinking about. I was considering the number of cases in the population, as opposed to a vaccination providing immunity for a particular individual.

Sort of. It's really complicated, though.
Different vaccines all work differently, and the epidemiology of various diseases is all different from disease to disease. You have to look at each disease separately.
Back to the chickenpox vaccine, in Japan (where the vaccine was used sparingly) it looked (or was) over 90% effective with a single dose, and immunity lasted over 30 years.
In the US where it was used universally, the effectiveness dropped and vaccine immunity wanes more quickly. Because the vaccine works just well enough to slow down spread of the virus, but then you get something called "secondary vaccine failure"...where the immunity wanes because people aren't getting their immunity boosted by exposure to the wild virus.
But what's true for chickenpox isn't necessarily true for measles, or pertussis, etc. They're all different.
Interesting stuff, which indicates that vaccination programs are generally implemented not because of the individual benefits for those vaccinated, but for the entire community.
I point out this quote is not from the source, it is from another post of Ivor's, I guess.

This source does not support Ivor's conclusions and his interpretation of this citation is a pretty good example of his less than logical thought processes.

What does the source actually say about the "purpose of vaccinations" and "individual protection"?
Most discussions of life-long protection focus on individual protection. This is an important consideration for any vaccine. However, we as a society derive far more benefit by seeking protection for all by eliminating exposure to infectious diseases.
(emphasis mine in the actual citation quote and in Ivor's quoted post)

What does the source actually say about, "The way vaccination is sold to individuals at the moment is often by misleading them into thinking being vaccinated will protect them directly by a significant amount"?
For example, use of a cellular pertussis vaccines in Japan among 2-year-old children led to marked reductions of pertussis among younger children who were not targets for vaccination (20). Similar effects have been seen in the United States with Haemophilus influenzae type b and measles (21, 22). Any effort to induce life-long immunity requires that vaccines be used and used widely among targeted groups.
Ivor's logic? Because there was a reduction in a group not vaccinated, the vaccine must have been useless in the group actually vaccinated. Really? Then how did it work in the non vaccinated group?

What does the source actually say about, "Realistically, vaccination only "works" if enough of the population get vaccinated. The lower the efficacy of the vaccine, the more people in the population need to be vaccinated for it to have a significant effect"? (emphasis mine)
When there are high levels of immunity in the population, the likelihood that a transmitting case will come in contact with a susceptible person is reduced, thereby resulting in indirect protection of the few remaining susceptibles, including those too young for vaccination, those with legitimate contraindications to vaccination, and those whose vaccination fails to protect them. While there is no absolute level of population immunity short of 100% that will guarantee elimination of disease transmission, it is clear that the higher the level of immunity, the lower the probability of significant transmission (19).
(emphasis mine)

What does the source actually say about waning varicella vaccine immunity?
Live attenuated viral vaccines are generally believed to induce long-term, probably life-long, protection among the great majority of individuals (9). Measles, mumps, rubella, and oral polio vaccines are in this category. Inactivated vaccines and toxoids usually induce shorter-term protection and require periodic boosters. Experience with a number of the newer inactivated vaccines, such as hepatitis B vaccine and enhanced-potency inactivated polio vaccine, is too limited to know the precise duration of immunity (15, 16). Immunologic memory, even in the absence of detectable antibody, may confer life-long protection.
In other words, nothing.


And what does Ivor also misunderstand from the source in his next post?
SUMMARY
Life-long protection from disease through immunization can be accomplished through individual or community protection. Individual protection is the goal for vaccination against diseases that have inanimate or animal reservoirs or that pose risks for certain populations. Community protection is the goal for vaccination against diseases that are transmitted only from human to human. Community protection afforded by childhood vaccines has been highly successful against measles, rubella, mumps, and polio. However, outbreaks of measles, rubella, and mumps continue to occur, primarily because of inadequate immunization of children under age 2. Simplification of vaccination regimens, provision of incentives to care providers and parents, and increased access to care should improve vaccination rates in the United States. Better protection requires better use of available vaccines. Eradication of disease through vaccination is the ultimate goal of community protection. Elimination of the infectious agent is the most effective means of achieving life-long protection. The World Health Organization's (WHO) smallpox eradication campaign eliminated a serious disease as well as the need for a vaccine with frequent and severe adverse reactions. The discontinuation of smallpox vaccination in the United States has produced a savings of over $3 billion. Polio has been targeted by WHO for eradication by the year 2000. The eradication of polio and the elimination of the need for polio vaccination in the United States should result in a savings of $110 million per year in vaccine costs alone. Strong United States support is crucial for WHO to reach its goal. Any of the vaccine-preventable childhood virus diseases could be eradicated with sufficient national and international will. Measles and hepatitis B should be high priorities. The ultimate goal of vaccination is life-long protection of all individuals. Any disease of sufficient public health importance to warrant routine vaccination is of sufficient importance to warrant eradication wherever judged to be possible.
(emphasis Ivor's)

That supposedly supports the claim, "which indicates that vaccination programs are generally implemented not because of the individual benefits for those vaccinated, but for the entire community". (emphasis mine)

And then there is this claim in post #39, "Yes, it does. Only if the vaccination leads to 100% immunity does the incidence of the disease become irrelevant."

Huh? So if the vaccine reduced the incidence of measles to near zero it isn't relevant?

In the same post Ivor claims after citing a source explaining how BCG vaccine benefits people in high prevalence TB areas, "A figure of 50% on average does not seem very effective at preventing TB." Not only does he have a poor understanding of the citation he quotes, but if it were to be interpreted as he claims, he is saying a 50% reduction in a disease responsible for 2 million annual deaths worldwide is not useful!


That is page one. I don't have time to bother with the nonsense on pages 2-13 but anyone who cares to look won't have any trouble finding more of the same.
 
So, guys... when are we going to divert all those public funds for something useful, for a change ? Like preventing all car accidents ?
 
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There are lots of 'public funds' going to prevent car accidents in the way of highway safety features and requirements car manufacturers install safety features which the consumer then pays for.

I said from the beginning, if you wanted instead to look at all money spent in either risk reduction or medical interventions and you compared each measure in the big picture, then you could determine where vaccine spending fell relative to other measures. Ivor wants to just look at vaccines in isolation and compare the cost/benefit based on his personal individual values.

If we are just going to look at Ivor's pet peeves, then I have no problem disagreeing with his self centered world view. From my world view, I value preventing the rare risk of an unacceptable consequence, my child's death, and find cost of vaccines to be well worth their value. I agree with the conclusions of the ACIP in making the determination which vaccines are warranted.

If you want to evaluate the cost per life saved then it's heroic measures for single individuals you should be going after.
 
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