As a person with some fairly minimal background in science, I find comprehension of some phenomena beyond my grasp - multiverses, quantum mechanics, extra dimensions. These things are beyond my day to day experience, so I don't ponder on them very much, and haven't a hope of getting a eureka-type understanding any time in the future.
In the past (and to some extent even today), phenomena that did directly affect a person's existence but seemed inexplicable (because those asking the questions lacked the scientific knowledge to do so) led them to seek supernatural explanations -for example: Why is there a drought? Why did the sun disappear? Why did my child die?
The creation of an omnipotent/omniscient/omnipresent deity on whom blame or praise could be heaped as appropriate is a perfectly natural response, but you must see that it is fundamentally wrong. Lack of understanding as to how something apparently incomprehensible happens does not mean something magical must have caused it. To paraphrase Dawkins (I think)- "If you don't know how something happened, don't try and work out how it did, just give up and appeal to God."
I too wonder about the big questions such as why are we here and how we got here. One cannot look at miracles like the emergence of a butterfly from its cocoon or a baby turtle struggling out of its egg without marvelling at the wonder of life, or look at a supernaova through a telescope without being stunned by the magic of the universe, and not feel that there should really be an all-embracing answer for it all. But as tempting as it may be, logic must show you it is not a valid conclusion, but merely superstition manifesting as a means to obtain a solution that you can accept. When one's brain receives information that seems inconsistent with the beliefs one holds or with natural logic, but which it consciously or subconsciously knows is true, it copes with the inconsistency by overriding the "dissonant" information. This is termed cognitive dissonance, and is a way to help people overcome these internal contradictions and continue to function and accept situations, even when there is good evidence their preconceptions are incorrect. We all have cognitive dissonane to a degree, for different things. With some it may manifest in the existence of a god, for others it may indicate vaccines cause autism.
The proposition that a deity gave origin to life the universe and everything is a common one, but as we know, popular concepts are not true by reason of their popularity, especially when there is no evidence for their existence. Why do we need to postulate the existence of a creator?