Questions about Acid/base, Oxygen Imbalances

Kumar

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Hello all,

I came across with some concepts as under:-

Bohr Effect
The Bohr Effect is an adaptation in animals to release oxygen in the oxygen starved tissues in capillaries where respiratory carbon dioxide lowers blood pH. When blood pH decreases, the ability of hemoglobin to bind to oxygen decreases. Hemoglobin binds to oxygen in the oxygen-rich atmosphere of the lungs, and releases it in the oxygen-poor environment of the tissues.

The primary function of hemoglobin is to carry oxygen from the lungs to tissues. The Bohr Effect aids in this function by releasing oxygen to the tissues when the concentration of hydrogen ions becomes large. At low pH the Bohr Effect allows the blood to unload oxygen for use by the muscles. Therefore, the Bohr Effect is necessary for the body to function.

Mitochondria
Mitochondria are often referred to as "the powerhouses of cells". They are cellular organelles that perform oxidative phosphorylation in eurkaryotic animal and plant cells. The main function of mitochondria is to produce energy via respiration, where oxygen is used to turn food into a form of energy (stored in ATP) that the cell can use. Because mitochondria produce energy, they are abundant in tissues which require a lot of energy such as muscle.

http://www.iscid.org/encyclopedia/Bohr_Effect
Click to expand...

The above effects indicate that acidic/low blood pH improves Oxygen availabilty to tissues.

How can this concept be related diabetes, Insulin resistance & hypertension?

Best wishes.
 
Don't you just love it when your research is not done properly, Kumar?

Tell me, are you a fully 100% Bible-believing Christian, Kumar? You'd better be...

The site you got that from is under the management of one William A. Dembski, one of the leading proponents of the Intelligent Design movement in America. This is a group of people who want to have Intelligent Design taught in US schools. "Intelligent Design" has another, more applicable, name - Christian Creationism. Christian Creationism holds that God created the universe according to His design, i.e. their science is based on Christian biblical precepts only.

In other words, Kumar, that site is a religious front pretending to be scientific. So I'd be fairly circumspect about any of the "facts" it claims as "truth". Look elsewhere - see what other sites say about this. Here's one example you MUST read and understand before you go any further: http://www.aw-bc.com/mathews/ch07/c07be.htm
 
Kumar said:
Hello all, The above effects indicate that acidic/low blood pH improves Oxygen availabilty to tissues.

NO, IT DOESN'T.

How can this concept be related diabetes, Insulin resistance & hypertension?

Basically, by means of an umbrella and a piece of string. I think Abraham Lincoln is involved in this somewhere too. Oh, and a pigeon. And an orange.
Click to expand...
 
Kumar said:
Zep,

Is it wrong?
Click to expand...
Is WHAT wrong? Be more specific. And if you ARE more specific, don't you think that YOU can answer that question yourself? If you CAN'T answer it yourself, how on earth are you going to understand any answers WE might give you?

Your understanding of the Bohr Effect certainly is wrong, judging by the silly questions you posed at the end. That shows that you have failed to understand (or even read) all the clear, excrutiating detail that has been provided for you for free. And DON'T ask me or anyone else here to explain it for you - all the answers you want are all there for you to find yourself.

Off you go now.
 
Whether the definition of Bhor effect as mentioned by me is wrong? Pls participate in discussions if it interests you & avoid this & that type unpleasent postings.
 
Kumar said:
The above effects indicate that acidic/low blood pH improves Oxygen availabilty to tissues.

How can this concept be related diabetes, Insulin resistance & hypertension?
Click to expand...
Good question. How do you think these can be related, Kumar?
 
Some more details are:-

What this means is that as the amount of carbon dioxide increases, more H+ are formed and the pH will decrease. Thus, a lower pH in the blood is suggestive of an increased carbon dioxide concentration which in turn is suggestive of a more active tissue that requires more oxygen. According to Bohr, the lower pH will cause Hb to deliver more oxygen! Just what we want to occur.

Note that if pO2 and pH should drop together, even more oxygen will be delivered then if only one of the parameters were changed (for example, pH = 7.2, pO2 = 30 mm Hg compared to pH = 7.4, pO2 = 30 mm Hg).

A few more items to add to your knowledge base: If the pH of the tissues should rise (due to a drop in the carbon dioxide concentration), the the % Saturation curve shifts to the left (not shown) and results in less oxygen being delivered. Does that make sense? Also, there are several other factors that will also affect the binding of oxygen to Hb. One of these is temperature. A more active tissue will be producing more heat and will be warmer. This increased temperature shifts the curve to the right (not shown) just as decreased pH does. Is this beneficial to the tissue? Why?
http://www.austin.cc.tx.us/~emeyerth/bohr.htm
Click to expand...

What most people refer to as insulin resistance, I think is a misnomer. I think that insulin is probably doing its job but getting blamed for the
results. Glucose transfers from the blood into cells by a process called facilitated osmosis. Insulin facilitates in this transfer by opening the door which glucose may flow into the cell. When this door is opened, the transfer of glucose into the cell is done via osmosis, a substance flowing from an area of greater concentration to lesser concentration.


In a health body, the cell rapidly burns glucose so when insulin opens the door, a concentration gradient exists, there is less glucose inside the cell than outside the cell, so glucose flows to the area of lesser concentration, inside the cell.


What happens when metabolism becomes impaired? Glucose is not burned as rapidly in the cell. Insulin opens the door, but becuase there is still a lot of glucose that has not yet been burned, there is still almost as much glucose inside the cell as outside the cell, a strong concentration gradient does not exist, glucose can not move as rapidly into the cell.
The result is that blood glucose levels remain elevated for a longer time.


Over time, the cell gets weary of insulin opening the door and letting in more glucose that it reduces the number of doors that insulin can open.

Insulin gets the blame but insulin was doing its job.

On possible cause of impaired metabolism is a block in the mitochondria. Mitochondria processes are aerobic, they require oxygen to function. In the lack of oxygen delivery they cannot operate.

A too alkaline pH blood can interfere with the transfer of oxygen into the cell. (Do a google search on "Bohr Effect") I believe that this alkaline blood pH is a contributing factor for people with CFS-FMS and that that condition is probably leading that group into type 2 diabetes.
Click to expand...

At google, I was indicated the above concept. Can you comment on this.
 
Kumar said:
Over time, the cell gets weary of insulin opening the door and letting in more glucose that it reduces the number of doors that insulin can open.
Click to expand...

In other words, the cells become resistant to the effects of insulin. Hence insulin resistance.

--Terry.
 
Kumar said:
Whether the definition of Bhor effect as mentioned by me is wrong? Pls participate in discussions if it interests you & avoid this & that type unpleasent postings.
Click to expand...
The definition appears fundamentally similar to the one I referenced. However your questions indicated clearly that you have understood neither of them.

And I'm not being unpleasant, just brutally honest with you. You are the child that refuses to eat its breakfast just to be stubborn and contrary.
 
Zep, Instead of finding faults & doing just contradictions, you may just contribute.

Mojo, pls reply accordingly.

Terry, it is commonly understood that insulin/excess insulin is the reason of IR. Can't it be possible that if available Oxygen is defficient or alkaline pH, insulin resistance takes place? Modern lifestyle & environment is said to be a cause of epidemic type spread of diabetes, hypertension etc. in modern times, which probably can be due to excess gastric acid secretion & lower oxygen intake(shallow breathing) due to polluted environment?
 
Kumar said:
Zep, Instead of finding faults & doing just contradictions, you may just contribute.

Mojo, pls reply accordingly.

Terry, it is commonly understood that insulin/excess insulin is the reason of IR. Can't it be possible that if available Oxygen is defficient or alkaline pH, insulin resistance takes place? Modern lifestyle & environment is said to be a cause of epidemic type spread of diabetes, hypertension etc. in modern times, which probably can be due to excess gastric acid secretion & lower oxygen intake(shallow breathing) due to polluted environment?
Click to expand...
WARNING!!! This poster is looping.
Would all other posters who have already been around the Kumar subject loop once before kindly disembark from the thread. Next Kumar subject loop will commence in about 20 posts time.

Thank you.
The Management
 
Argh! I hope this smashing head into brick wall isn't going to cause permanent damage!!! Aughghghg!!!!
 
Zep said:
WARNING!!! This poster is looping.
Would all other posters who have already been around the Kumar subject loop once before kindly disembark from the thread. Next Kumar subject loop will commence in about 20 posts time.

Thank you.
The Management
Click to expand...

How he has mentioned this type of post & used as "The Mamagement"?
 
originally posted by Kumar

Quote
----------------------------------------------------------------------------------
What most people refer to as insulin resistance, I think is a misnomer. I think that insulin is probably doing its job but getting blamed for the
results. Glucose transfers from the blood into cells by a process called facilitated osmosis. Insulin facilitates in this transfer by opening the door which glucose may flow into the cell. When this door is opened, the transfer of glucose into the cell is done via osmosis, a substance flowing from an area of greater concentration to lesser concentration.


In a health body, the cell rapidly burns glucose so when insulin opens the door, a concentration gradient exists, there is less glucose inside the cell than outside the cell, so glucose flows to the area of lesser concentration, inside the cell.


What happens when metabolism becomes impaired? Glucose is not burned as rapidly in the cell. Insulin opens the door, but becuase there is still a lot of glucose that has not yet been burned, there is still almost as much glucose inside the cell as outside the cell, a strong concentration gradient does not exist, glucose can not move as rapidly into the cell.
The result is that blood glucose levels remain elevated for a longer time.


Over time, the cell gets weary of insulin opening the door and letting in more glucose that it reduces the number of doors that insulin can open.

Insulin gets the blame but insulin was doing its job.

On possible cause of impaired metabolism is a block in the mitochondria. Mitochondria processes are aerobic, they require oxygen to function. In the lack of oxygen delivery they cannot operate.

A too alkaline pH blood can interfere with the transfer of oxygen into the cell. (Do a google search on "Bohr Effect") I believe that this alkaline blood pH is a contributing factor for people with CFS-FMS and that that condition is probably leading that group into type 2 diabetes.
---------------------------------------------------------------------------------



At google, I was indicated the above concept. Can you comment on this.
Click to expand...

Kumar, where did you find this quotation? I've tried googling for it several times (for example, looking for the phrase "cell gets weary" or various other combinations of words from the quotation) but Google won't find it.
 
Kumar said:
Modern lifestyle & environment is said to be a cause of epidemic type spread of diabetes, hypertension etc. in modern times, which probably can be due to excess gastric acid secretion & lower oxygen intake(shallow breathing) due to polluted environment?
Click to expand...
No, it's due to overeating and not enough exercise.
 
Mojo,

This was an awnser from one google group at sci.med.cardiology.
 
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