Wrath of the Swarm said:
Calculating? Rolfe, you don't understand. The accuracy of the test is the value we calculate other values from in the presented problem.
In any situation, the test is 99% likely to give the correct answer. That's the whole point of the question - people get confused between the idea that the test is right 99% of the time and the idea that the chance of it being accurate in a specific, particular case is only 9%.
If you're told only that the test is 99% accurate, that holds no matter what other conditions apply. From this, it follows that the alpha and beta rates are identical.
There is no information missing. You're just not capable of deriving information you weren't presented with.
Wrath, you're digging deeper and deeper into "make it up as you go along".
Nobody will ever tell you in practice that any serology test is "99% accurate", because accuracy isn't a defined term in the vocabulary of this problem. BillyJoe has kindly posted a list of (almost) all the defined terms and how they are defined, which I reproduced above. These are the words we professionals use when talking about these things.
You keep talking about "people getting confused", but from the evidence presented so far on this thread, the most confused person is yourself. I think because you have learned by rote a particular example case which has a non-intuitive answer, and which can thus, by careful phrasing of a trick question, be used to ambush medical types. However, you have not really got anywhere close to coming to grips with the permutations and variabilities possible unless the parameters of the question are
extremely carefully nailed down in advance.
Since you made the mistake of not nailing down the parameters of the question when you originally posed it, you are coming up against aspects of the problem you never even thought about.
Now, can I ask again. What do you mean by "alpha and beta" rates? I'm assuming this is another way of saying sensitivity and specificity, but I've never encountered this before, so would you mind confirming that this is the case, and revealing which is which?
And about that "accuracy" figure again. When I said, how do I calculate it, I meant that if I were characterising an assay, how would I derive the figure from the raw data? The same way BillyJoe detailed how you would derive figures like the specificity or the positive predictive value from a set of raw data.
Raw data for characterisation of the test is quite easy.
Group of patients, x% of whom have the disease (prevalence, as I keep saying a mobile and artificial concept), and you already know by some other means (reference method) which is which. Test them all. Some of the affected patients will test positive, TP. Some of them will test negative, FN. Some of the unaffected patients will test negative, TN. Some of them will test positive, FP. This is your starting point. I can derive all the defined characteristics of any assay lfrom these numbers - have to, it's all you're going to get. BillyJoe showed you how this is done. I want the same level of understanding from you about how you derive your "accuracy".
Rolfe.