New antiquack blog

Lately I've noticed that many "snake oil salesmen" have come with some rather impressive credentials, such as the Nobel Prize, National Medal of Science, and professor positions at major universities. I won't mention names, but they're readily available by a search engine inquiry.

This is a scary trend. I've seen several associated with many "miracle cure" type of products with little or no scientific support.

Is their association simply motivated primarily by financial gain? In the long run, wouldn't the loss of respect and credibility among their peers offset any short term economic benefit?

How is a layperson expected to discern between academics who remain committed to the scientific method and those who sell out to embrace more mundane incentives?
Perhaps you are, in part, referring to the Nobel winner who touted vitamin C as a cure-all?
His problem was it wasn't his area of expertise. Another scientist in Engineering at Princeton was out of his depth when controls were lax on his "anomalous phenomena" studies. Not to mention some scientists that become completely schwartzed.
 
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They're still scientists. They should recognize they're out of their depth. I think coming from different fields is a very small part of the problem.

I was referring, also, to the more recent (1998) Nobel Prize winner for Physiology or Medicine.........
 
Originally Posted by verisimilidude
Lately I've noticed that many "snake oil salesmen" have come with some rather impressive credentials, such as the Nobel Prize, National Medal of Science, and professor positions at major universities. I won't mention names, but they're readily available by a search engine inquiry.

This is a scary trend. I've seen several associated with many "miracle cure" type of products with little or no scientific support.

Is their association simply motivated primarily by financial gain? In the long run, wouldn't the loss of respect and credibility among their peers offset any short term economic benefit?

How is a layperson expected to discern between academics who remain committed to the scientific method and those who sell out to embrace more mundane incentives?
Perhaps you are, in part, referring to the Nobel winner who touted vitamin C as a cure-all?
His problem was it wasn't his area of expertise. Another scientist in Engineering at Princeton was out of his depth when controls were lax on his "anomalous phenomena" studies. Not to mention some scientists that become completely schwartzed.

its quite a thing really, to feel that you are capable to criticize the actions of someone who has more knowledge than yourself, someone with "impressive" credentials, simply because these more erudite scholars challenge your basic world view - how can your knowledge possibly evolve if you cannot even have a little respect for people that are smarter and more accomplished than you?

if you were a true rationalist, then you would have to have an open mind until you could find that specific flaw in their logic operation that yields material results that do not correspond with said logical operation

however, as we see on this list, even such objective evidence is conveniently ignored, simply because it doesn't conform the mathematical assumptions of some statistical model that your apparently most erudite follow, i might guess, even in matters of the heart

it seem to me, that most skeptics are not rationalists at all - they are fundamentalists - the taliban of thought

the thing is, most haven't a clue how to apply Aristotle's three laws of thought, nor are able to see the inherent problem with them, especially with the first law, the law of identity

mathematicians love to claim that they can explain Zeno's paradoxes, but many of these remain unsolved, not because they cannot per se solved mathematically per se, but because those who try to solve apparently have no capacity to comprehend something called "context", and the true intent behind them

since rationality extends from the logic of Aristotle, a deeper investigation into the views of his antecedents would seem appropriate: of course Plato and Socrates, but most importantly, the elder Parmenides

what is clear is that on this forum, is that the what Parmenides called the "Way of Opinion" dominates the thinking here: no end to constant argumentation

i invite rationalists to probe the nature of their own consciousness, and observe the nature of perception itself - skeptics will probably be too skeptical to even try - they are hopeless cases and when they die will have only the confusion of the loss of their body to contemplate

for those who are reasonable, don't try to think or argue your way our of this - just sit, and observe the function of perception, and make it a practice - 30 minutes in the morning after you wake

during this time, let go of your assumptions, and indeed, any attachment to any thought - if you need to focus on something, just focus on your breath - nothing else

and when you do this, when you behold the nature of perception itself, you may for a moment discover the alternative to the Way of Opinion, what Parmenides called "The Way of Truth"

in this mind, you will be more careful about your opinions, perhaps a little more humble and less likely to jump to conclusions about things that you have to be honest about, that you don't really know

i know i will be flamed for this, but i offer it the spirit it is given, for one brief moment consider it a détente

but for those that persist in their opinions that their believes exist as some kind of independent truth, as "fact" - i will continue, until it no longer amuses me, to pop them as i would an effervescent bubble , "full or sound and fury, signifying nothing"

have a happy life, and hopefully, a good death too
 
No, no. The problem is that some "scientists" have adopted a new mantra.

Instead of "show me the evidence", it has become "show me the MONEY!"
 
No, no. The problem is that some "scientists" have adopted a new mantra.

Instead of "show me the evidence", it has become "show me the MONEY!"

you're right, that never happens in medicine

current research shows that big pharma spends, on average, $60,000 per physician on marketing and advertising - nearly twice their R&D budget

greed is endemic to the world my friend - wish is weren't so but that seems to be a compulsion of human nature, except perhaps, in those who take vows of poverty for some spiritual purpose

however, i know of no skeptic that has taken such any such vow, of course as most are avowed anti-spiritualists, and so we can assume that skeptics also suffer from this same endemic delusion (among several), even if its only the lusty thought of being "right"
 
the double-blind placebo controlled trial cannot be used to ascertain the mechanism of action of polyherbal pharmacy, which is how the vast majority of herbalists practice

I'm not going to take Vaidya's bait, but I do want to comment on this for the rest of the forum readers because it is a commonly repeated misconception. There is a simple way to test polyherbal pharmacy. The herbalist prescribes, but does not dispense. The dispenser prepares (1) what the herbalist prescribed and (2) a different herbal mixture or a non-herbal placebo. The dispenser labels these and keeps records. A third party actually gives the preparations to the patients. So neither the herbalist, the patient, nor the person giving the preparation to the patient knows what the patient is actually getting. After outcomes are measured, the code is broken. And to double-check that the placebo control was adequate, patients are asked whether they thought they got the placebo or the active preparation.

Proponents of alternative medicine often claim that their treatments deserve some special exemption from the usual scientific methods, but they don't offer any more reliable method of determining the truth, and while they find fault with scientific studies that show their treatments are ineffective, they seldom find fault with any scientific study that does support their beliefs.
 
I'm not going to take Vaidya's bait, but I do want to comment on this for the rest of the forum readers because it is a commonly repeated misconception. There is a simple way to test polyherbal pharmacy.

I'm not sure what you are calling "bait" here. Such vague and slightly insulting terminology isn't going to advance your cause. If you want to convince people, and I am speaking of people who are skeptical, not those already firmly in your camp, you need to be clear, direct, and scientific about it. Back up everything with either sources, or reasoning.

The best I can find might be this:
there is simply no way to study this effectively, because every person would have to be given the same formula against a placebo - but that doesn't actually reflect how herbal medicine is practiced, since herbal formulas are compounded on the basis of the individual signs and symptoms

Which is a valid point. Herbal formulas are often custom tailored, and modified as patients progress, or react to the substances. Be that as it may, it is still possible to test some standard ones.

The herbalist prescribes, but does not dispense. The dispenser prepares (1) what the herbalist prescribed and (2) a different herbal mixture or a non-herbal placebo. The dispenser labels these and keeps records. A third party actually gives the preparations to the patients. So neither the herbalist, the patient, nor the person giving the preparation to the patient knows what the patient is actually getting. After outcomes are measured, the code is broken. And to double-check that the placebo control was adequate, patients are asked whether they thought they got the placebo or the active preparation.

That is exactly the kind of testing that is done with both individual herbs, as well as formulas.

Proponents of alternative medicine often claim that their treatments deserve some special exemption from the usual scientific methods, but they don't offer any more reliable method of determining the truth, and while they find fault with scientific studies that show their treatments are ineffective, they seldom find fault with any scientific study that does support their beliefs.

Now there is a good example of an opportunity to make a point.You made several claims there. What is needed, is clear evidence to back them up. If you really want to convince people, and not just preach to the Choir, you have to show both why you believe that, as well as good sources of information that support your statements.

Unless you are just seeking acclaim from like minded people, just saying something is not enough.

For example, you said "Proponents of alternative medicine often claim that their treatments deserve some special exemption from the usual scientific methods". If this is true, you should be able to point to several examples of this, in published literature, illustrating what you are saying. This gives weight to your argument, and does not demand anyone take things on faith, or on your authority.

If you want people to accept evidence based medicine, as well as your views on it, you can't use the same flawed methods that you attack, to make your case. You have to show evidence, and show reasoning to back up your conclusions.

Going back to your statement, " it is a commonly repeated misconception", examples would be more helpful than just your claim. In just a matter of minutes, I found many studies done on herbal formulas, double blind and everything, and none of them claimed any special exemptions, or tried to say testing could not be done.

They looked for both effectiveness as well as side effects.

So it should be easy for you to find examples to support your view. I hope this helps.
 
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there is simply no way to study this effectively, because every person would have to be given the same formula against a placebo - but that doesn't actually reflect how herbal medicine is practiced, since herbal formulas are compounded on the basis of the individual signs and symptoms

None of this is different from medical treatments - we don't use the same treatments for different individuals, sometimes multiple drugs are used. It is still possible to subject this to DBPCT. I'll give you two examples.

Consecutive patients with a particular condition or symptom complex (whatever criteria you think would be useful) are enrolled in the study. After you have determined the desired herbal formula for that patient, the patient is given either the actual herbal formula or an identical placebo in a double-blind, randomized manner. All the patients are followed at regular intervals and assessed in whatever manner you consider relevant (as long as it is consistently done) for whatever outcome you consider relevant.

Patients with a particular condition or symptom complex (whatever criteria you think would be useful) are examined and the desired herbal formula is determined. Those patients who have a particular herb or collection of herbs recommended to them are enrolled in the study and receive either the herb(s) or an identical placebo in a double blind, randomized manner. All the patients are followed at regular intervals and assessed in whatever manner you consider relevant (as long as it is consistently done) for whatever outcome you consider relevant.

The first design is a test of herbalism in a particular condition. The second design is a test of a particular herb(s) in a particular condition. Both represent the usual practice of herbalists.

we have established that you have preconditioned bias that won't allow to shift your paradigm - see the problem with DBPCT above

Can you provide some specific reasons for why the above studies could not be done?

how convenient! the fact is, her IOP has remained normal since, despite a year of it being consistently high prior to coming to see me

you may try to attribute this to being an artifact or normal variation but that would be illogical

If it is within the range that we expect to see, how is it illogical to observe that it is in the range we expect to see? That her average reading is in the low 20's means that variation will sometimes put it in the mid 20's and sometimes put it into the normal range.

c'mon linda, put your glasses on!
comparatively the amount of $$ spent on herbal research is a drop in the bucket

this is why there are very few phase II or III clinical trials on herbs - who is going to pay for it? once again, your statements demonstrate your ignorance of this field of research

Who is going to pay for it? Whoever is paying for the research that has already been done. Take the money that is wasted on performing low-quality clinical trials (where even positive results cannot be taken as evidence of effectiveness) and perform high-quality clinical trials instead. Then you can at least draw valid conclusions from the results. It takes very little to add randomization or to change your control group to a placebo instead of some other treatment.

The drug companies are not the only source of research funds. Until recently, they haven't even been the main source (in the US).

glad to see you can read a website, but the site actually contains very little info and none relating to the research problems i refer to - what? are you chicken? give her a call and ask some questions instead of insulating yourself with ignorance

If you are unable to convey this information, fine. I will not ask it of you. But I already have considerable training, knowledge and experience in this area, and having been there myself, it is inappropriate for you to ask to me bother a busy professional just so you can deflect a discussion you are incapable of maintaining.

Natural Standard is NOT a bastion of herbal medicine
for one thing, there are no herbalists that work for them

Now, how did I know you would say that. :)

Linda
 
no its not - i posted an additional reference that you did not comment on
please read the thread more carefully linda

I pointed out that your reference was simply a number pulled out of someone's *** as opposed to the other number which was based on actual data. I looked through your posts again, and I don't see that you addressed that issue or provided any other references. Can you point me to where you did so?

Linda
 
HERBS ARE NOT DRUGS!!


If you want to support that statement, you'll need to produce evidence showing that herbs don't contain pharmacologically active substances. Unfortunately for you, you have already copied and pasted a large number of abstracts suggesting that they do. Your first step must therefore be to discredit all the studies you've posted.
 
If you want to support that statement, you'll need to produce evidence showing that herbs don't contain pharmacologically active substances.
Addendum: Or, if they do, that the pharmacologically active substances are not the reason the herbs are used.
 
oh yes mum, thanks mum, sorry mum
what what jolly good and all that crap

perhaps you should ask yourself why you take time to _publicly_ critique my typing form instead of the substance of my posts

Then help us understand the substance of your posts. It is very difficult to get to what you are saying amongst all the personal insults. As mentioned before you claim herbs are not drugs, yet you seem to feel they have pharmaceutical properties and are useful.

Please clarify if herbs are:

1) Food with no biological effect.

2) Actually cause biological effects, which would make them pharmaceutical active.

I also wonder why you seem to feel that food has no biological effect.
 
Which is a valid point. Herbal formulas are often custom tailored, and modified as patients progress, or react to the substances. Be that as it may, it is still possible to test some standard ones.

In the example I gave, custom tailoring would be possible, as well as modification during the course of treatment. One group would get exactly what the herbalist prescribed at each stage, and the other group would get a placebo.
 
Now there is a good example of an opportunity to make a point.You made several claims there. What is needed, is clear evidence to back them up. If you really want to convince people, and not just preach to the Choir, you have to show both why you believe that, as well as good sources of information that support your statements.

Unless you are just seeking acclaim from like minded people, just saying something is not enough.

For example, you said "Proponents of alternative medicine often claim that their treatments deserve some special exemption from the usual scientific methods". If this is true, you should be able to point to several examples of this, in published literature, illustrating what you are saying. This gives weight to your argument, and does not demand anyone take things on faith, or on your authority.

If you want people to accept evidence based medicine, as well as your views on it, you can't use the same flawed methods that you attack, to make your case. You have to show evidence, and show reasoning to back up your conclusions.

Going back to your statement, " it is a commonly repeated misconception", examples would be more helpful than just your claim. In just a matter of minutes, I found many studies done on herbal formulas, double blind and everything, and none of them claimed any special exemptions, or tried to say testing could not be done.

They looked for both effectiveness as well as side effects.

So it should be easy for you to find examples to support your view. I hope this helps.

I don't think it's necessary to substantiate the claim that many alternative proponents claim special treatment, since Vaidya has just provided a typical example.
Yes, herbalists do studies. Some of the studies they cite are from Asia, where 98% of the studies are positive; because of this bias, I hesitate to accept the results of any Asian study until it has been replicated in a good study elsewhere. I do not question the fact that herbs have medical effects: in fact, that was the whole point of Dr. Novella's article, which Vaidya seems not to have understood. Yes, there are many studies supporting herbs, but the quality of those studies varies; some of them are right, but most of them are probably wrong. Bausell's book explains why. One of the main thrusts of the Science Based Medicine blog will be distinguishing good science from not-so-good science.
 
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Obviously animals are immune to the placebo effect, and one thing I know about pet owners, they know when something works on their pet.


In that case, you know nothing at all about pet owners!

They are just as susceptible to the placebo effect by proxy as any person is to that effect on themselves - perhaps even more so, because they are only interpreting the pet's behaviour, not actually feeling what it feels.

My favourite anecdote on this one concerns a lab mix-up. Smokey and Greymalkin were two cats presented to the same vet, and both were tested (on the same day) for possible hyperthyroidism. My lab mixed the samples up. We told the vet that Greymalkin was hyperthyroid but Smokey was not, when in fact the opposite was the case.

A week later the vet submitted a repeat sample from Smokey in the course of further investigation, and at this point I smelled a rat. Comprehensive investigation of sample labels and so on revealed the truth. I phoned the vet and grovelled.

The vet was remarkably forgiving, however Greymalkin had been started on (entirely unnecessarly and with a slight risk of toxicity) treatment for hyperthyroidism. I begged the vet to handle it as best she could, and reported that our insurance was up to date.

The vet came back to me to say that everyone was being very sensible about it, and Smokey's owners were merely pleased that a definite diagnosis had been reached after all. Her main difficulty with Greymalkin's owners was in getting them to stop the anti-thyroid medication, because they were so convinced the cat was better because of it!

There are squillions of similar stories. One of the problems vets encounter is breaking it to an owner that their pet is not in fact any better, even though they have convinced themselves that it is. Persuading an owner that they can see an improvement when in fact none is there is, sadly, not difficult. People want to see improvement, and so they see it.

Rolfe.
 
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In that case, you know nothing at all about pet owners!

They are just as susceptible to the placebo effect by proxy as any person is to that effect on themselves - perhaps even more so, because they are only interpreting the pet's behaviour, not actually feeling what it feels.

And the pet may actually feel better because the owner's faith in the placebo may alter his behavior towards the pet. Extra attention, etc.
 
The data dump you provided exemplifies several things. First it illustrates that (as I said) it is easy to find the data; but it takes a good education to interpret it. Second, the collection typifies the lack of sophistication in study design, and irrational exuberance in the claimed conclusions, seen in most herbal research.

Even I can tell these studies, singly or together, don't support any use of the herb. A cursory count shows the 6 studies looked at 4 conditions. Moreover, the dosages and measured outcomes are inconsistent; therefore, they do not add to strong evidence for any use. In addition, each study has too few subjects to be taken as anything more than a pilot study.

A brief summary:
Studies:
#1 Twelve subjects, no control group, chronic congestive heart failure, added “flexible diuretic, vasodilator and digitalis dosage.” Not Definitive (ND).

#2 Ten subjects, used a proprietary product (Hartone) not TA, stable angina pectoris, no control group, different protocol and outcome measures from #1. ND

#3 Different outcomes assessed (antioxidant), different dosage regimen, … ND

#4 Same dosage regimen as #1, stable angina, different outcomes measured, only <40 patients in TA/placebo arms … ND

#5 Examined endothelial function in smokers, 18 subjects, different outcomes measured. ND

#6 Forty subjects, dosage frequency not stated, different outcomes measured, quantitative results not given. ND

This is why I wrote that I had already seen most of the data supporting use of herbs. These papers are, indeed, new to me; but they look like all the others- just the herb and condition varies from time-to-time.
vaidya

You offered a set of citations to support claims for this herb. I claimed (with specified reasons) that they are inadequate to support use of this material. Can you rebut my claim?
 
In that case, you know nothing at all about pet owners!

False claim. A good example of bad science. Pet owners know without a doubt when their animal has diarrhea, when they refuse food, when they are passing foul gas, and many other obvious symptoms. They also can tell when such symptoms stop. Is it the herbal formula? Or would the problem have gone away on it's own?


Either way, you missed the point, that the term "homeopathic" is being used on herbal formulas.

They are just as susceptible to the placebo effect by proxy as any person is to that effect on themselves - perhaps even more so, because they are only interpreting the pet's behaviour, not actually feeling what it feels.

Do you have any evidence to show that to actually be true? Or is this just anecdotal evidence? Is there any science behind your claim?

There are squillions of similar stories.

All of them worthless when it comes to evidence based medicine.


And the pet may actually feel better because the owner's faith in the placebo may alter his behavior towards the pet. Extra attention, etc.

Again, is there any evidence to show that is true? Panic attacks, which some dogs suffer from (triggered by thunderstorms, fireworks) are unmistakable, and no amount of attention will "cure" them. Drugs can alleviate the symptoms, but there is no doubt about pet owners knowing when it occurs, or when it subsides. If a "homeopathic" remedy stopped panic attacks, that would be remarkable. But finding it is actually a potent herbal tincture, was quite a shock. It makes the whole homeopathic thing suspect, and possibly explains why some people swear by "homeopathy". It isn't really homeopathy, it is herbal medicine.
 

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