I wondered whether some kind of shields are possible, but I don’t know if they are. At least those like you see in Star Trek. Physical shields would add a lot of weight but maybe they are the only realistic idea. And would even those be eroded away during the journey.
The only possibility for such shields would be magnetic, there was a fad for Bussard ramscoop spacecrafts in science fiction - Niven and Pournelle often used the idea. They would say the immense electro-magnetic fields that scooped up the interstellar hydrogen also acted as a form of shielding. (If I remember correctly further work on the likes of the Bussard ramjet idea showed they wouldn’t work or produce so little acceleration that it would take a million years or so to get up to earth scale speeds.)