I am currently working in an area where within the last month two people died from being outside. I am dead serious: they were outside, dehydrated, and died. THAT is nature. In contrast, artificial interventions such as artificial refrigeration, insulation, camelbacks, backpacks, hats, high-tech fabrics, etc. have kept those working under me alive. Pretty clearly illustrates the errors of the OP, I should think.
As for randomly selecting something in nature, it's an issue of scale. On average, if we limit ourselves to Earth, what you select will be under enough pressure to turn your bones int diamonds, and hot enough to flash-boil you while it lights your bones on fire. If we expand our scale to include even the Earth/Moon system, on average you will select nothing. If we limit ourselves to a random thing in an ecosystem, it'll be air, soil, or water. My point is that the question makes a presupposition regarding the nature of reality that simply doesn't stand up to even the most casual critical analysis.
If we limit ourselves to foodstuffs, it actually gets worse. I'm currently in the Mojave Desert. Many of the staples of this area prior to Europeans ariving on the scene required extensive processing--baking in limestone pits, for example, or soaking in rivers. Even meat is extremely dangerous if you don't process it. We don't just cook meat because we like grill marks.
The real issue with edible items found in nature in regards to health is that the concentration of any useful chemical will be highly variable. Well, the concentration of ALL chemicals will be highly variable--meaning that you may get a lot of the good stuff and little of the bad stuff, vice versa, or anything in between.
There are two issues with artificial chemicals intended for human consumption: concentration and synergy. Artificial chemicals are always (or almost always) at higher concentrations than they can be found in nature, which can cause problems. And artificial chemicals are typically far more pure than their natural counterparts, which means they lack any other chemicals to synergystically interact with. Either of these can be overcome--primarily because we can know there's something TO overcome. In natural items, this is not the case. You can't fix what you don't know is broken.
phildonnia said:
In the abstract, I would sooner eat a random chemical found in the ancestral environment than a random synthetic chemical.
In all honesty, and without any hyperbole or exageration, I would probably kill anyone who demanded I make that choice. I would consider it an act of self defence--no one who forced me to make such a choice could be viewed, rationally, as anything other than a deadly foe intent on killing me.