By not up to date I mean the following :
Vancomycin isn't strictly speaking produced by Streptomyces orientalis, it was reclassified as Nocardia orientalis then reclassified again as Amycolatopsis orientalis.
It's the same with Rifamycin - the organism which produces it was changed from Streptomyces mediterranei to Nocardia mediterranei to Amycolatopsis mediterranei to Amycolatopsis rifamycinica.
Not all Tetracyclines come from Streptomyces rimosus some come from Streptomyces aureofaciens.
Florey wasn't actually British - he was Australian, Chain was British but was born in Germany.
It says Penicillin was discovered by Alexander Fleming in 1929 - it was actually discovered by Fleming in 1928.
Other than this the article seems pretty much correct.
Vancomycin isn't strictly speaking produced by Streptomyces orientalis, it was reclassified as Nocardia orientalis then reclassified again as Amycolatopsis orientalis.
It's the same with Rifamycin - the organism which produces it was changed from Streptomyces mediterranei to Nocardia mediterranei to Amycolatopsis mediterranei to Amycolatopsis rifamycinica.
Not all Tetracyclines come from Streptomyces rimosus some come from Streptomyces aureofaciens.
Florey wasn't actually British - he was Australian, Chain was British but was born in Germany.
It says Penicillin was discovered by Alexander Fleming in 1929 - it was actually discovered by Fleming in 1928.
Other than this the article seems pretty much correct.
Ernest Duchesne did discover an antibiotic but it wasn't 'Penicillin' as we know it.
He isolated the substance from Penicillium glaucum ( gorgonzola mould).
Penicillin as we know it today comes from a different type of Penicillium - Penicillium chrysogenum ( formerly Penicillium notatum.)
The 2 substances also showed different properties.
So it wasn't infact Penicillin but a similar substance.
Unfortunately Duchesne's research was forgotten about until Fleming discovered a similar case.
He isolated the substance from Penicillium glaucum ( gorgonzola mould).
Penicillin as we know it today comes from a different type of Penicillium - Penicillium chrysogenum ( formerly Penicillium notatum.)
The 2 substances also showed different properties.
So it wasn't infact Penicillin but a similar substance.
Unfortunately Duchesne's research was forgotten about until Fleming discovered a similar case.
For example the substance Duchesne isolated was active against Salmonella typhi and E.coli ( both gram negatives ) but Penicillin as we know it has activity almost exclusive to gram-positive bacteria with a few notable exceptions such as the organism which causes Gonorrhoea & Meningococci.
Eos of the Eons
Mad Scientist
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- Jul 23, 2003
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Are you copying this from a book?