Well, in the general sense of it's saying we don't know something exists, it's the same.
In the specific sense of why he's saying it, it's very different.
Why is it different? Because there is a great deal of evidence that there is no Santa, whereas there is very little evidence that there are no ETIs.
To put that slightly differently: of the two possibilities:
a) there is no santa
b) there is a santa
"a" is the far more parsimonious conclusion.
Of the two possibilities:
a) there are no ETIs
b) there are ETIs
there is some evidence that leads us toward "a", and some that leads toward "b", but neither has any particularly compelling evidence, so the best we can do is to say, "we don't know".
Internet forums are where the uninformed get a chance to preach. You have ignored lots of fundamentals. For example, one fundamental you ignore is that no one cares if there is another planet with ETI with life all over it in another galaxy. In fact, Star Wars could be 100% factual. No one cares. No one cares because the distances between galaxies are too far to care.
No one cares if a creature called Santa exists in some place where we have no hope of every seeing or knowing of.
And ALL of the evidence talken completely leads us to think we are alone in the galaxy and the more we learn the more alone we seem and the fewer places for ETL AND ETI to hide get smaller and smaller.
I am discussing on another web forum the fact that the Book of Abraham has been debunked with a Mormon. I show him the facts and he simply cannot see it. It is as if his brain simply cannot see simple logic. His faith blinds him. It is also our faith in ETI that is the reason why Fermi's Observation is called Fermi's Paradox. We simply cannot see it eventhough it is very simple to understand.
Then again, maybe for some people it is not simple to understand. Maybe most people cannot fathom billions of years. I9 billion years is a hell of a long time. If ETI came about commonly in nature, the Milky Way would be 100% colonized. That is all. We came about late in the game. Our sun and planets came from an older exploded stars. There were lots and lots of star systems before then. I have explained this lots of times. Why is it, in person, I can get people to see this but on the interent I am just wasting my time?
Science works like this. If you belive something exists, you have to prove it. It does not work the other way. You do not prove that something does NOT exist. That is impossible.
Let me put it this way. It is highly improbable that there is anyone in the Milky Way like us. In fact, it is a huge waste of money.
A multi-millionare friend of mine, Paul Allen, has build a huge telescope array in California to find a signal form ETI. Paul is not a scientist. He is basically a rich guy with a lot of faith and dreams. I think that he should have thrown that money towards cancer research. Ironically enough, he has gotten cancer.
Before Seti@Home was launched people would spend their retirement money and kids college funds on radio equipment listening for signals. It seems to me that they did this because our culture raises us to believe that is it impossible for us to be alone.
The irony of ironies is that if they was ETI, they would not be interested in us at all because we are so stupid.