Nie Trink Wasser
Graduate Poster
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who here LOVES the stuff ?
Gravy and Thalidomide
- Thread starter Nie Trink Wasser
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- gravy thalidomide
who here LOVES the stuff ?
Nie Trink Wasser
Graduate Poster
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alright, guess I offended.
today was the first day I had ever heard of this problem and drug.....
it's fascinating to me.
today was the first day I had ever heard of this problem and drug.....
it's fascinating to me.
aggle_rithm
Unregistered
A
LeFevre said:
You could amputate all your limbs and pretend you are a Thalidomide baby
*Sigh*, it just wouldn't be the same.
Seriously, thalidomide is a promising drug for advanced cancer. (I believe it's called an "angiogenisis inhibitor".) It prevents the formation of new blood vessels to feed the tumors. Theoretically, you could live with a tumor for years. It doesn't go away, but it never gets any bigger.
Unfortunately, the body usually figures out a way to thwart the effect.
aggle_rithm
Unregistered
A
BillyJoe said:
I don't think so. Unless I'm mistaken, the tumor doesn't generate blood vessels, the body does in response to the growth of the tumor. That's what Thalidomide prevents. Since the body WANTS to generate new blood vessels to accomodate growth, it eventually becomes resistant to the drug. Not soon enough to keep babies from being born without arms and legs, though.
shemp
a flimsy character...perfidious and despised
I came here for the gravy! Where's the gravy???
I saw an interesting show (NOVA?) on PBS last year on this very subject. They showed how a cancer (tumer?) excretes a substance that causes new blood vessels to grow, and that a thalidomide metabolite, would stop the growth. I'll see if I can find a link tomorrow.
aggle_rithm said:
http://cancerpage.com/cancernews/cancernews4293.htm
This type of tumor at least, is too clever for Thalidomide.
Dog
spoonhandler
Unregistered
S
aggle: It's thought the tumour stimulates the growth of new blood vessels (process called angiogenesis). When tumours are less than ~3mm in diameter, they can get nutrients/oxygen by perfusion alone. For many solid tumours, angiogenesis has to take place for them to continue to grow beyond this size. There is a lot of research looking into anti-angiogenic strategies, but at the moment, we're all a bit taken aback to find they don't work so well for solid tumours, but seem to work well in haematogenous malignancies (leukaemia, myeloma, etc). This isn't understood very well yet.
In the example linked above, it was the tumour that 'thwarted' the drug, and very effectively too. That particular type of tumour is very good at thwarting all treatments thrown at it so far.
In the example linked above, it was the tumour that 'thwarted' the drug, and very effectively too. That particular type of tumour is very good at thwarting all treatments thrown at it so far.
Jon_in_london
Illuminator
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- Aug 7, 2002
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shemp said:
And we wont go until we got some
And we wont go until we got some
And we wont go until we got some
So bring some right here!
shemp
a flimsy character...perfidious and despised
Dammit, I've got a plateful of mashed potatoes, NOW WHERE'S MY GRAVY???
aggle_rithm
Unregistered
A
spoonhandler said:
OK, so I spoke out of pure speculation and had no earthly clue what I was talking about. SO WHAT!!!
Nie Trink Wasser
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YOU WANT SOME WHAT ?!
G R A V Y G R A V Y G R A V Y G R A V Y
G R A V Y G R A V Y G R A V Y G R A V Y
shemp
a flimsy character...perfidious and despised
Re: YOU WANT SOME WHAT ?!
Was that picture taken before the food was eaten, or after it was regurgitated?
Nie Trink Wasser said:G R A V Y G R A V Y G R A V Y G R A V Y
Was that picture taken before the food was eaten, or after it was regurgitated?