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Gardasil vaccine

BenBurch said:
It is not at all unusual for a few people to die of any vaccine.

Some people are allergic to the medium a vaccine is grown in, for one thing.

Sometimes the vaccine itself is dangerous.

The polio vaccine kills people. And not always the people it is protecting! It is a live vaccine, and when an older person who either never was vaccinated or whose immunity has faded changes the diapers they can contract it.

And sometimes the batch is contaminated or old or counterfeit.
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Do they still use live polio vaccine? The risks are low they are not what you would call usual. Now albumin allergy would be a real problem, but anaphlactic shock would be detectable,
 
Dancing David said:
Do they still use live polio vaccine? The risks are low they are not what you would call usual. Now albumin allergy would be a real problem, but anaphlactic shock would be detectable,
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Yeah, they do. And many have argued that the Sabin vaccine is a positive danger and should be abandoned for the Salk vaccine. The only reason we use the Sabin vaccine at all is an early contaminated batch of the Salk formulation that was not prepared according to specification, and which put the killed virus vaccine in disrepute.
 
The UK (and the US I think) have switched back to IPV in recent years because pretty much the only cases of polio were from the oral vaccine.
 
Professor Yaffle said:
Not the technical term, no. But it is the most common word used in everyday parlance for an injection, especially a vaccination. Although in Scotland "jag" is the more common form.
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OK... kind of like "shot" in the U.S.

I was just checking to see if the writer was using common vernacular, or if he wasn't a "real" writer. Thanks for the clarification.
 
Isn't this the first vaccine ever, for a sexually transmitted disease? Well, several of them at once.

I wonder why they don't force boys to get it as well.
 
robinson said:
Isn't this the first vaccine ever, for a sexually transmitted disease? Well, several of them at once.

I wonder why they don't force boys to get it as well.
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Off the top of my head, I think they are still in trials on boys, which should be done by the end of the decade.
 
robinson said:
Isn't this the first vaccine ever, for a sexually transmitted disease? Well, several of them at once.

I wonder why they don't force boys to get it as well.
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I think it was just a question of cost effectiveness, would (almost) double the cost while not increasing lives saved by very much. Plus if all women are vaccinated, the spread to men will be vastly reduced.

Edit - link to story about cost effectiveness of girls only versus girls and boys:

http://www.timesonline.co.uk/tol/life_and_style/health/article1295381.ece
 
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We examined the potential health outcomes and cost-effectiveness of quadrivalent human papillomavirus (HPV) 6/11/16/18 vaccination strategies in the Mexican population using a multi-HPV type dynamic transmission model. Assuming similar cervical screening practices, with or without vaccination, we examined the incremental cost-effectiveness of vaccination strategies for 12 year-old females, with or without male vaccination, and temporary age 12-24 catch-up vaccination for females or both sexes. The most effective strategy therein was vaccination of 12-year-olds, plus a temporary 12-24-year-old catch-up program covering both sexes; whereby HPV 6/11/16/18-related cervical cancer, high-grade cervical precancer, and genital wart incidence was reduced by 84-98% during year 50 following vaccine introduction. Incremental cost-effectiveness ratios in the primary analyses ranged from approximately $3000 (U.S.) per quality-adjusted life year (QALY) gained for female vaccination strategies to approximately $16000/QALY for adding male vaccination with catch-up.
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http://www.ncbi.nlm.nih.gov/pubmed/...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

We present a transmission dynamic model that can assess the epidemiologic consequences and cost-effectiveness of alternative strategies of administering a prophylactic quadrivalent (types 6/11/16/18) human papillomavirus (HPV) vaccine in a setting of organized cervical cancer screening in the United States. Compared with current practice, vaccinating girls before the age of 12 years would reduce the incidence of genital warts (83%) and cervical cancer (78%) due to HPV 6/11/16/18. The incremental cost-effectiveness ratio (ICER) of augmenting this strategy with a temporary catch-up program for 12- to 24-year-olds was US $4,666 per quality-adjusted life year (QALY) gained. Relative to other commonly accepted healthcare programs, vaccinating girls and women appears cost-effective. Including men and boys in the program was the most effective strategy, reducing the incidence of genital warts, cervical intraepithelial neoplasia, and cervical cancer by 97%, 91%, and 91%, respectively. The ICER of this strategy was $45,056 per QALY.
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http://www.ncbi.nlm.nih.gov/pubmed/...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Interesting.
 
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Damn. MERCK is making at least $300 a girl on this deal.














(checks stock portfolio)





Yes! We need to get every country in the world to make a law about this. Every girl in the world needs this.
 
My opinion is that this is where "Eminent Domain" would be well applied. Strip Merck of this patent and make the vaccine for free distribution in a government-contracted laboratory. Because $300 per is profiteering.
 
In the UK, any intervention costing less than £30,000/QALY is considered worthy of consideration for use if there is strong evidence for its effectiveness.

I don't know where the £30,000/QALY figure comes from or how it is justified.

Anyone?
 
BenBurch said:
My opinion is that this is where "Eminent Domain" would be well applied. Strip Merck of this patent and make the vaccine for free distribution in a government-contracted laboratory. Because $300 per is profiteering.
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The US has a 4 million birth cohort per year. Thus:

2,000,000 * $300 = $600,000,000 per year.

If a booster is required, double that number to $1.2 billion / year to extend the life of each member of the cohort an average of a few days.
 
Blue Wode said:
Thanks for your replies everyone, although I’d still like to know why it can’t be determined what the two girls mentioned in the OP died from.

....
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I found a Health Canada report:
http://www.cmaj.ca/cgi/content/full/177/10/1169 that says
Some of the 9 deaths were duplicate reports, while 1 patient turned out to be "very much alive," Allen added. There are 4 confirmed deaths in girls or women who received the HPV vaccine, but it is not known to have caused any of those deaths.

In 2 cases, women died after suffering pulmonary embolisms, but they were also taking birth control pills, a known risk factor, says Allen. In 2 other instances, girls had influenza, and myocarditis resulted in the death of 1 of those patients.
"The deaths do not appear to be connected at all with the vaccine," Allen says. "It appears to be a very safe and effective vaccine and we believe it's very important to women's health."
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robinson said:
Isn't this the first vaccine ever, for a sexually transmitted disease? Well, several of them at once.

I wonder why they don't force boys to get it as well.
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Hepatitis B is a sexually transmitted disease for which there is a vaccine.

Gardasil is not the first cancer vaccine either. I don' know which came first but BCG is used to treat bladder cancer and again hepatitis B vaccination prevents hepatitis B induced hepatocellular carcinoma.
 
Capsid said:
Hepatitis B is a sexually transmitted disease for which there is a vaccine.

Gardasil is not the first cancer vaccine either. I don' know which came first but BCG is used to treat bladder cancer and again hepatitis B vaccination prevents hepatitis B induced hepatocellular carcinoma.
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As a first responder (I was on the Motorola Emergency Response Team when I worked for them) I got the Hep-B Vaccine long ago. But I still carry an Ambu-Shield on my keychain because I'm just not going to do CPR without some protection.
 
Professor Yaffle said:
I think it was just a question of cost effectiveness, would (almost) double the cost while not increasing lives saved by very much. Plus if all women are vaccinated, the spread to men will be vastly reduced.

Edit - link to story about cost effectiveness of girls only versus girls and boys:

http://www.timesonline.co.uk/tol/life_and_style/health/article1295381.ece
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You need to point out the most relevant part of this article:
The study, carried out by three researchers from Merck Research Laboratories into the best strategy for using the cervical cancer vaccine Gardasil, shows that the greatest reductions are achieved if both boys and girls are targeted
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Merck think tank:

"Damn shame that cervical cancer only affects girls, huh?"
"Yeah, maybe we could contrive a way to persuade people there is a case to vaccinate the boys too. We'd double our massive profits overnight."
"Hmm... how about a study showing that if both sexes are vaccinated there would be a reduction in the time lag taken to achieve full protection?"
"Yes, that could work..."
 
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