The paper demonstrates Darwinian mechanisms are insufficient and so supports ID in that sense.
First of all, the paper does NOT demonstrate Darwinian mechanisms are insufficient. The paper does not take into consideration a great many things: cumulative probability, co-option, transpositions, gene-pool variation strategies, etc.; These are well understood to be relevant to lots of other evolutionary processes. None of his work seems to take any of them into account.
Furthermore, the paper does not even properly address the process of natural selection, which he misconstrues as a process left to "chance".
Secondly,
even if he did find that Darwinian mechanisms are not sufficient for something:
That does NOT automatically mean Intelligent Design is right. There are other possabilities to consider:
1. Other natural processes could be involved, that do not require intelligence. Perhaps such as the auto-catalytic processes studied under abiogenesis. Or, perhaps a new form of networking-theory could be discovered to account for how things tend to clump together.
2. The enzymes might not have been designed, but rather mutated out of bad experiments on the part of the Designer. Axe's findings do not address alternatives to the presumed
intentional design of life forms.
3. Those enzymes, and in fact everything in the Universe, were created last Thursday, as the Universe routinely cycles through infinite possabilities of everything. Any memories before that time were also created on that day, but of course it won't feel like it. This idea may sound stupid, but I do not think I.D. has any way to demonstrate that its position is any more realistic.
(If you disagree, demonstrate otherwise.)
In short, as you admit, Axe is not actually finding an alternative explanation. He is merely trying to claim one particular one is not accurate. In fact, he really does not make any new empirical findings, at all.
Thirdly, some scientists have worked out some of the selection forces at work in enzyme and protein folding:
http://www.febsletters.org/article/S0014-5793(01)03232-X/abstract
http://bohr.winthrop.edu/faculty/hu...les/Protein Folds Functions and Evolution.pdf
http://onlinelibrary.wiley.com/doi/10.1002/cbic.201000771/full
I will see if I can find better references, later. But, my point is that it is NOT impossible for evolutionary pathways to emerge for the types of things Axe was studying.
It's scope is justifiably narrow in that sense. Axe may propose a new mechanism or evos may as well, but that's not the point in this specific, narrowly structured work.
Do you have a better example, then? Because this one does not reflect much of Intelligent Design's power.
For answering his objections, Axe redefines Darwinism as a search algorithm, and does so in a way that
does not take cumulative probability into consideration; only straight adding-up of some numbers. He is actually ignoring a great portion of the whole natural selection paradigm.
His findings might, indeed, have implications for the type of 'evolution' he is defining. But, it does NOT address evolution the way evo scientists understand it.
My Objections:
#1: He is NOT invoking an Intelligent Designer. He is merely wasting everyone's time with work that will not go anywhere nor do anything.
#2: It is important to study the evolution of protein folding, because improper folding lead to disease (
http://en.wikipedia.org/wiki/Protein_folding#Incorrect_protein_folding_and_neurodegenerative_disease ), and we would like to know what genetic factors are relevant to that, and how they tend to spread through the history of life.
Axe's work is actually counter productive to such efforts.