JJM
I am responding to your comments drawn from Dr. Joe Keating's 2001 article:
1. A prophylactic or health-maintaining effect of manipulation has not been experimentally demonstrated to date.
I'd like to draw your attention to this article, published the year before Joe wrote his comments:
Maintenance Care: Health Promotion Services Administered to US Chiropractic Patients Aged 65 and Older, Part II
J Manipulative Physiol Ther 2000 (Jan); 23 (1): 10–19
Available in the LINKS Section of Chir

rg
The important points from this article are:
A:
The cost of health care for patients receiving MC in this study was far less than that for patients of similar age in the general population, despite the doubling of physician visits (chiropractic visits vs. medical visits). The greatest difference in health care costs with patients receiving maintenance care was in the areas of nursing care and, especially, hospital care. This reduced need for hospital and nursing home services has recently been corroborated by the research of Coulter et al. [Review the Coulter et al statistics]
B: Chiropractic patients receiving maintenance care, when compared with US citizens of the same age,
spent only 31% of the national average for health care services and reported a 50% reduction in medical provider visits.
C: The health habits of patients receiving maintenance care were better overall than the general population, including decreased use of cigarettes and non-prescription drugs. Furthermore,
95.8% believed the care to be either “considerably” or “extremely” valuable.
2. The value of “regular check-ups” by chiropractors is also unknown.
The last article discusses "maintenance" (aka wellness, aka asymptomatic) care, and does find significant differences between chiropractic patients and their matched peers.
3. The disease-producing and pathology-producing effects of subluxation-complex, if any, have not been demonstrated experimentally.
I presume that you are not a doctor, so I'll keep these comments simple. The classic explanation of the subluxation complex is:
Kinesiopathology, or loss of alignment and/or motion irregularities (the 739 and 839 and the 737 ICD-9-CM codes),
Neuropathology, which occur due to compressed or facilitated nerve tissue (the 722-24, 353 ICD-9-CM codes),
Myopathology, or soft tissue changes due to muscle and ligament damage, involving spasm, muscle weakness/atrophy and development of myofascial disorders (the 728-29, 847 ICD-9-CM codes),
Histopathology, or the pre and post inflammatory changes that result as sequela to the primary soft tissue damage, progressing from edema to congestion of tissue to eventual remodeling (the 719, 782 ICD-9-CM codes), and
Pathophysiology, or the degeneration and/or fibrous tissue formation which are the inevitable outcomes of poor management of the other components (the 732-39, 723 ICD-9-CM codes).
There is significant (though unrelated) studies that demonstrate each of these processes. They are too extensive to list here, but much of this material is archived on the Chir

rg website in the Research and LINKS Sections:
The LINKS and Research Section are both available at Chir

rg
4. Adjusting has not been experimentally demonstrated to alter vertebral alignment or “nerve pressure”; such effects, if possible, have not been shown to influence neuritis.
You seem to be relying on relatively ancient chiropractic theories for your critique, because of the use of the term "nerve pressure". Chiropractic has been shown to reduce radiculopathy, and radiculopathy has been shown to evolve from irritated facet joints. Please refer to the Radiculopathy Page.
Available in the LINKS Section of Chir

rg
5. Currently available experimental data do not justify any claims for the value of chiropractic care in populations of children.
Wrong! There has been negative results in trials on colic and asthma, but the results for low back pain, thoracic spine pain, neck pain, and headaches has been positive. I'd like to quote a passage from a newly published article:
"numerous claims made by chiropractors over the years, based on their clinical observations, have not stood up to critical analysis and the results of studies often suggest that these observations are due to placebo or the natural course of the disorder rather than the actual treatment. This has been true of a vast number of medical treatments. A recent Special Issue of The Spine Journal on Evidence Informed Management of Chronic Low Back Pain listed over 200 treatments currently being offered patients with low back pain, most of which are offered by medical physicians [3]. Of these, less than 10% have a reasonable body of support based on high quality clinical trials. The greatest research support was for therapies commonly used by chiropractors including the manual therapies, education and exercise."
"Commentary on the United Kingdom evidence report about the effectiveness of manual therapies"
Chiropractic & Osteopathy 2010 (Feb 25)
The conclusions from this extensive review are:
"Spinal manipulation/mobilization is effective in adults for: acute,
subacute, and chronic low back pain; migraine and cervicogenic headache;
cervicogenic dizziness; manipulation/mobilization is effective for several
extremity joint conditions; and thoracic manipulation/mobilization is
effective for acute/subacute neck pain. The evidence is inconclusive for
cervical manipulation/mobilization alone for neck pain of any duration,
and for manipulation/mobilization for mid back pain, sciatica,
tension-type headache, coccydynia, temporomandibular joint disorders,
fibromyalgia, premenstrual syndrome, and pneumonia in older adults. Spinal
manipulation is not effective for asthma and dysmenorrhea when compared to
sham manipulation, or for Stage 1 hypertension when added to an
antihypertensive diet. In children, the evidence is inconclusive regarding
the effectiveness for otitis media and enuresis, and it is not effective
for infantile colic and asthma when compared to sham manipulation. Massage
is effective in adults for chronic low back pain and chronic neck pain.
The evidence is inconclusive for knee osteoarthritis, fibromyalgia,
myofascial pain syndrome, migraine headache, and premenstrual syndrome. In
children, the evidence is inconclusive for asthma and infantile colic. "
"Effectiveness of manual therapies: the UK evidence report"
Chiropractic & Osteopathy 2010 (Feb 25)
This article, in particular, addresses the difference between clinical experience, opinion, and verifiable, reproducible, and measurable results in a clinical trial.
I understand that you (like myself) have opinions, but this study helps us to distinguish between our perhaps-biased opinions and the realities of scientific conclusions.
I certainly have issues with the asthma trials published in the past, primarily because they ignore the fact that both the placebo and active treatment groups improved in symptoms compared with controls. The conclusion was wrong, because it was based on the premise that the "placebo" had no effect.
Today researchers are becoming more aware of the "non-specific" effects of care generated by the "laying on of hands" and the sense of hope generated by the distinctly different way in which a chiropractor interacts with a patient. I have collected a variety of articles on this topic:
The Problem with Placebos/Shams
In Chir

rg's Research Section
Our website (Chir

rg) is devoted to collecting articles about chiropractic, from case studies through randomized trials. Over time, we will all better understand why chiropractic is so loved by clinicians and patients alike. Meanwhile, I see patients improve every day in my office when other forms of medical treatment had left them suffering. It is that joy I experience every day that helps he maintain my perspective when I read the negative comments posted on the anti-quack and science-buff nay-sayer websites.
I hope you will find these articles informative.
Warmly,
Frank M. Painter, D.C.
[email protected]
P.S. This website prevented me from posting URLs to the pages I quoted above, but each section of the Chir

rg website have their own Search Tools, so they can easily be found, if you are interested.