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Cass Report

The impact for precocious puberty is extremely different than for a natural puberty. Puberty is a two-part process that involves both the pituitary and the adrenal glands. GnRH agonists *only* halt the pituitary, they do nothing for the adrenal. The pituitary process during puberty governs bone density accretion, maturation of the sexual organs including breast growth in females, and increased coarseness of pubic, underarm, and leg hair for both sexes. It also triggers the growth of facial and body hair in males, as well as thickening of the voice box resulting in a lower voice. The adrenal governs lengthening of the long bones and closure of the growth plates after a certain period of time, as well as the initial growth of fine pubic, underarm, and leg hair.

In precocious puberty, the blockade stops the pituitary process until the adrenal kicks in. This prevents bone density accretion in bones that haven't lengthened, and prevents deformation of the legs and arms. Halting puberty in precocious puberty is 'reversible' largely because the adrenal triggers certain stages in the pituitary process, including the "halt" signal for bone density, and a few others that I'm not as conversant on. Once the adrenal has started its process, the child can stop taking the blockers and a normal puberty resumes until the adrenal sends some of those very important "stop now" signals.

In a normal puberty, it's not reversible. The adrenal has already started its process, and GnRH agonists don't affect it at all. If they're taken for a very short period of time (a few months at most), the impact is small and probably not very risky... but it might also depend on exactly where in the process the child is. Bear in mind that one of the more blatant issues is that the adrenal will cause the long bones to grow... but the pituitary isn't on-line to increase bone density. That's a time-bound process - kids can only acquire density in that window. If you stop taking the blockers partway through, the kid will have some increased bone density, but are likely to be permanently osteopenic. If blockers continue until after the adrenal causes the growth plates to close, they will never be able to gain density and can have permanently osteoporosis from before they're even fully adults.

The claim that blockers are temporary or reversible is perhaps the worst myth out there. They really aren't. And that's before we even get into the side effects of those drugs, which aren't something to scoff at.
Most of this is untrue. It is strange you talk about the pituitary but leave out the gonads which are the primary source of sex hormones, and talk about the adrenals which aren't primary producers of sex hormones. Adrenarche is a different process from menarche.

May I suggest if you don't understand the (complex) process of puberty you learn about it before you opine on it.
 
What if we actually already know the harm caused by the thing being studied? Is it worth having a clinical trial of children to test whether the laxative effects of mercury mixed with sugar outweigh the tremors, coordination issues, and memory loss?

That's why the puberty blocker trial was called out as unethical - we absolutely already know the dangers and the problems caused by the GnRH agonists themselves, as well as the problems having the pituitary and adrenal processes out of sync. So we'd be testing known actual real dangers against a hypothetical improvement in mental health that is far, far from certain. Most people don't think that's a reasonable tradeoff, and it's doing actual damage in pursuit of a highly doubtful emotional offset.
Do you know the benefits? How do you know the harms if you have done no studies?
 
Do you know the benefits? How do you know the harms if you have done no studies?

Have you just returned from a long holiday on Mars or something? We have an extremely good idea of the harms, from many individual cases where the harmed people have come forward and told their stories (including court cases), from people who have been given the drugs for other conditions, and from animal studies.

There is bugger-all evidence of benefit beyond the short-lived effect you get when someone gets something they desperately want, and beyond that the sunk cost fallacy, and that thing that isn't just a river in Egypt.
 
I know I disagree with Rolfe and Emily's Cat, but as a woman who had gender dysphoria as a teenager and grew out of it, I am mostly on their side. All I am saying is that partitioning off gender dysphoria as no go zone for scientific research is not a good thing. Teen females and I guess teen males suffer from this, it can contribute to suicide, it is not a trivial thing you grow out of for some persons. It is a genuine area for research, but it is a difficult area as Rolfe and Emily's Cat demonstrate.
 
I suggest a better analogy is abortion.

It's a lousy analogy. Abortion is not legal because society, while agreeing that it shouldn't happen, has decided to allow it as an alternative to back-street abortions.

Your analogy is more like, we should legalise cannabis, and heroin, and crack cocaine and all the rest, because people will just get these things from other sources anyway.
 
Have you just returned from a long holiday on Mars or something? We have an extremely good idea of the harms, from many individual cases where the harmed people have come forward and told their stories (including court cases), from people who have been given the drugs for other conditions, and from animal studies.

There is bugger-all evidence of benefit beyond the short-lived effect you get when someone gets something they desperately want, and beyond that the sunk cost fallacy, and that thing that isn't just a river in Egypt.
Anecdotal evidence is low level evidence. Why won't you allow research to be done? I have actually done endocrine clinics dealing with people who are transitioning, so I do have some understanding of the issues; but I wouldn't claim to be an expert. My anecdotal evidence is I don't think transitioning is a great option but for some people it may be the best of available options.

Whilst I appreciate Rolfe and Emily's cat have strong views on the harms caused from puberty blockers, reviews don't support their opinions. the evidence for harms or benefits is not strong. Clearly indicating the need for further research (COI statement I am not currently nor have I previously done research in this area, I am not currently applying for grants to research gender dysphoria.)

 
It's a lousy analogy. Abortion is not legal because society, while agreeing that it shouldn't happen, has decided to allow it as an alternative to back-street abortions.

Your analogy is more like, we should legalise cannabis, and heroin, and crack cocaine and all the rest, because people will just get these things from other sources anyway.
You may or may not be aware that some societies don't allow legal abortion. You may or may not be aware that some societies do allow legal cannabis because they believe the harms from making it illegal are greater than from making it legal.

As a woman I am strongly empathic to the view that mtf trans people should not be allowed into exclusively female areas. however I do not think that is the same issue as to whether a particular individual may suffer less if they transition from ftm or mtf.
 
I know I disagree with Rolfe and Emily's Cat, but as a woman who had gender dysphoria as a teenager and grew out of it, I am mostly on their side. All I am saying is that partitioning off gender dysphoria as no go zone for scientific research is not a good thing. Teen females and I guess teen males suffer from this, it can contribute to suicide, it is not a trivial thing you grow out of for some persons. It is a genuine area for research, but it is a difficult area as Rolfe and Emily's Cat demonstrate.

Anecdotal evidence is low level evidence. Why won't you allow research to be done? I have actually done endocrine clinics dealing with people who are transitioning, so I do have some understanding of the issues; but I wouldn't claim to be an expert. My anecdotal evidence is I don't think transitioning is a great option but for some people it may be the best of available options.

Whilst I appreciate Rolfe and Emily's cat have strong views on the harms caused from puberty blockers, reviews don't support their opinions. the evidence for harms or benefits is not strong. Clearly indicating the need for further research (COI statement I am not currently nor have I previously done research in this area, I am not currently applying for grants to research gender dysphoria.)


Please explain where anyone has attempted to "partition off gender dysphoria as no go zone for scientific research", or indeed where I have said I "won't allow the research to be done." Firstly, this discussion is only about paediatric medical transition. Treatment of adults isn't even being challenged here. Secondly, I think in pretty much every post I have made, I have said something like, if you want to go ahead with experiments on children, first do a proper follow-up on the thousands of children who were "treated" by the Tavistock before the mounting horror got them closed down. Second, do a comprehensive series of animal experiments on appropriate non-human subjects. Don't dive into a very very poorly designed and ill-thought-out experiment on vulnerable children without these data.

Yes, I am confident that if all this is done, there will be no human experimentation. But do the bloody preliminary research if you want to justify it.

Another thing that needs done is a rigorous examination of why blocking puberty might potentially be beneficial. We know the downsides, and there are many. What is actually being achieved by doing it - as opposed to the people who persist in wanting medical transition into adulthood doing it then? Boys may "pass" better, but that seems more in comparison to all the middle-aged men who transitioned rather than the men who transitioned in their twenties. (Bear in mind that Blaire White is an adult transitioner.) Girls aren't going to be any different. The unspoken justification seems to me to be merely "because they want this very badly". That's not good enough.

There's another reason I think it wouldn't go ahead. The trans contagion is on the wane. Although it's still being pushed in schools by indoctrinated teachers, the younger cohort of children are laughing at it all. In a few years the demand for paediatric transition is going to fall off a cliff. It's going the way of indigo children, if you remember that.

And don't you think that the lack of access to the historical data is something a bit suspicious? These children were originally treated as part of a trial! Only no results were published and the Tavistock just opened it up to more and more children without any documented justification or outcomes data. The lack of scientific rigour is breathtaking. But the data exist, even if they're not complete. However the subjects have become adults and have been treated for years by the adult service. Cass bust a gut trying to get them to release these data, anonymised, but was met with a flat refusal. As far as I can recall, some sort of legislation was passed through parliament to require the release of the data, but the clinicians went right on refusing.

Why is this? Is it even possible that they have no patient records? I don't think so. There are no confidentiality issues that can't be addressed by proper anonymisation of the data. The conclusion that these zealot clinicians know very well that the outcomes are terrible is hard to ignore.

You think that for some people transitioning may be the best option. However, I have seen absolutely no evidence to suggest that, even if you could identify these people when they're still pre-pubertal children, their outcome will be any better than if they do it as adults. And you're still ignoring the indubitable fact that without being able to tell which children will desist, the proposed trial would destroy the bodies of the ~80% of participants who would otherwise have become reconciled to their healthy, unharmed bodies after puberty.

The proposed trial is stopping the very process that leads to resolution of the distress in the vast majority of children.

ETA: I missed the "suicide" canard. Children with gender distress are not killing themselves in vast numbers. Suicide in this cohort is in line with suicide rates in other groups of children with comparable psychiatric morbidities. The thread "do you want a live daughter or a dead son" (or vice versa) was regularly used by the Tavistock clinicians to pressurise parents into giving consent, but this was pure coercion, not based in reality.

Another point is the existence of coexisting psychiatric and social morbidities. A ridiculous percentage of these children were autistic or had other conditions such as anorexia nervosa, OCD and anxiety. An eyepopping percentage were from broken homes or in care, and an absolutely gobsmacking percentage had fathers on the sex offenders register. Multiple detransitioners have spoken about the lack of attention to any of these conditions once the "gender" button had been pressed. It was as if this was the over-riding feature that negated everything else, and transition became the solution to everything. The lack of any probing about why these children wanted to transition was criminal. Some were believed by their clinicians to be fleeing sex abuse. Others, who were pre-gay, seemed to be trying to turn themselves straight by changing sex, due to internalised homophobia. Autistic children, who are often non-conforming misfits, were easy to persuade that the reason for this was that they were "really" the opposite sex. Many friendless children were attracted by the lure of the trans "glitter family" who promised to celebrate them and love them.

All of this has been swept under the carpet by the single "affirm, affirm, affirm" approach, and it's still going on. Surely the best outcome is for these children to become reconciled to reality, and to become comfortable with the healthy bodies they have? But the current approach, and the approach endorsed by this diabolical proposed "trial", is that the minute a child says the word trans, they are on the "Pathway". Just give all these kids puberty blockers, either now or in a year, knowing that ~80% of them, supported to go through puberty unharmed, and treated for their other psychiatric and social ills, would desist anyway. It's a deeply, deeply flawed proposal (read that open letter!) and frankly it's diabolical.
 
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You may or may not be aware that some societies don't allow legal abortion. You may or may not be aware that some societies do allow legal cannabis because they believe the harms from making it illegal are greater than from making it legal.

As a woman I am strongly empathic to the view that mtf trans people should not be allowed into exclusively female areas. however I do not think that is the same issue as to whether a particular individual may suffer less if they transition from ftm or mtf.

There's no need to be patronising. I am perfectly well aware of all that, and it's still a lousy analogy.

Accepting that there may be individuals who will have better lives if they transition, you repeatedly refuse to address the point that these people could still transition as young adults.
  • that way, you get rid of the problem of transitioning a huge number of children who would otherwise desist
  • that way, the people involved get to grow into healthy adults, with bone strength and fertility and so on
  • that way, they will be able to experience sexual pleasure
  • that way, informed consent becomes much more realistic
This isn't a debate about transitioning versus not transitioning. It's a debate about puberty blockers, and specifically about the proposed trial that's stirring up so much controversy. It's a debate about mass medicalising gender-confused children, as opposed to letting them grow up unmaimed, and make an informed decision as adults. This latter course having the great advantage of avoiding the harms in the bullet points above.

ETA: Did you read that open letter? I really think you should.
 
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As a parting shot, I have my own opinion as to why this appalling protocol has been railroaded as it has, and it is this.

If the researchers took the time to do the data analysis on the earlier Tavistock cohort, and commission and perform the animal studies, they'd have to pause all puberty blocking until the results were in. They do not want to do that, or face the rage and fury of the pro-trans lobby if they do.

If they designed a "placebo-controlled trial", something similar would apply. A much better protocol would be to randomise the subjects (or case-match them) into treatment and no-treatment groups. But when I say no-treatment, I mean no medicalisation. They would receive high-quality psychiatric support aimed at reconciling them to their true sex. But then of course all the children would have to get that support, or there would be no blinding. (Blinding wouldn't last, as the "control" group would experience puberty, but it could at least start blind.)

The trans lobby would go ballistic over that, for two reasons. One that some children would not get puberty blockers, and the other that all the children would be getting what they term "conversion therapy". Can't have that. Can't deny children the drugs, and can't possibly give them any psychiatric support.

They're too damn scared of the trans lobby even to contemplate these issues.

Cass's reaction to the suggestion that the lower age should be 14 years was telling. She said it would be pointless doing the trial on children who had already gone through puberty.
 
There's no need to be patronising. I am perfectly well aware of all that, and it's still a lousy analogy.

Accepting that there may be individuals who will have better lives if they transition, you repeatedly refuse to address the point that these people could still transition as young adults.
  • that way, you get rid of the problem of transitioning a huge number of children who would otherwise desist
  • that way, the people involved get to grow into healthy adults, with bone strength and fertility and so on
  • that way, they will be able to experience sexual pleasure
  • that way, informed consent becomes much more realistic
This isn't a debate about transitioning versus not transitioning. It's a debate about puberty blockers, and specifically about the proposed trial that's stirring up so much controversy. It's a debate about mass medicalising gender-confused children, as opposed to letting them grow up unmaimed, and make an informed decision as adults. This latter course having the great advantage of avoiding the harms in the bullet points above.

ETA: Did you read that open letter? I really think you should.
Yes, I did read the open letter, It was well written. The evidence base was not strong.

We don't differ on the principles, just on the 'where are we now'. You are certain of current knowledge, I think current knowledge is weak.

You accept that there may be individuals who have better lives if they transition, but they then deserve the research on the best way to transition. You ask valid questions, the questions need research, not banning transition by law (which is how I interpreted your previous post; but I accept this may be not what you intended to convey).

I don't know whether puberty blocking e.g. from 12 to 16 then transitioning with a trans puberty, is better than going through cis puberty then trying to reverse the cis puberty and transitioning post 16. This is a legitimate research question.
 
As a parting shot, I have my own opinion as to why this appalling protocol has been railroaded as it has, and it is this.

If the researchers took the time to do the data analysis on the earlier Tavistock cohort, and commission and perform the animal studies, they'd have to pause all puberty blocking until the results were in. They do not want to do that, or face the rage and fury of the pro-trans lobby if they do.

If they designed a "placebo-controlled trial", something similar would apply. A much better protocol would be to randomise the subjects (or case-match them) into treatment and no-treatment groups. But when I say no-treatment, I mean no medicalisation. They would receive high-quality psychiatric support aimed at reconciling them to their true sex. But then of course all the children would have to get that support, or there would be no blinding. (Blinding wouldn't last, as the "control" group would experience puberty, but it could at least start blind.)

The trans lobby would go ballistic over that, for two reasons. One that some children would not get puberty blockers, and the other that all the children would be getting what they term "conversion therapy". Can't have that. Can't deny children the drugs, and can't possibly give them any psychiatric support.

They're too damn scared of the trans lobby even to contemplate these issues.

Cass's reaction to the suggestion that the lower age should be 14 years was telling. She said it would be pointless doing the trial on children who had already gone through puberty.
I absolutely agree with you that there was an atrocious lack of research and follow up on patients going through the Tavistock, but this was a funding issue. I looked at the research as a gender dysphoric teen ager. Perhaps, I was lucky, I was bright and had a mother who did sexual health clinics so I could read articles on reassignment. Also I am flat chested so the issue about breasts never arose. Also there is a clear confusion between sexuality and gender identity, a very difficult issue as a teen. So I don't agree that there are lots of things that should have been done better. That many children with gender dysphoria can be managed by time and psychological interventions.

I have previously said that my view if they did an RCT it should be early (pre-pubertal) vs. late (post pubertal) transitioning. BUT that should be for a select group, as I do not think early transitioning is appropriate for everyone, but the question is whether ibis appropriate for some.
 
There's no need to be patronising. I am perfectly well aware of all that, and it's still a lousy analogy.

Accepting that there may be individuals who will have better lives if they transition, you repeatedly refuse to address the point that these people could still transition as young adults.
  • that way, you get rid of the problem of transitioning a huge number of children who would otherwise desist
  • that way, the people involved get to grow into healthy adults, with bone strength and fertility and so on
  • that way, they will be able to experience sexual pleasure
  • that way, informed consent becomes much more realistic
This isn't a debate about transitioning versus not transitioning. It's a debate about puberty blockers, and specifically about the proposed trial that's stirring up so much controversy. It's a debate about mass medicalising gender-confused children, as opposed to letting them grow up unmaimed, and make an informed decision as adults. This latter course having the great advantage of avoiding the harms in the bullet points above.

ETA: Did you read that open letter? I really think you should.
Don't patronise me please.
 
I don't "accept that there may be individuals who have better lives if they transition," I am merely willing to continue the discussion on the assumption that that may be so. But consider, this is not a wide debate about transitioning, it is specifically about puberty blockers. The vast majority of people who have transitioned did not take puberty blockers. Please stick to the subject. I have never at any point suggested banning transition by law. I do suggest that banning the administration of puberty blockers by law is probably justified on the evidence available already.

I repeat, blocking puberty is in no way a necessary prerequisite for transitioning. Most people who have transitioned did so after experiencing normal puberty. That includes the poster boy and girl for "passing" trans, Blaire White and Buck Angel. So please, please stop misrepresenting me and start focussing on puberty blockers, not transition as such.

And really, you demonstrate your ignorance of this issue more and more with every post you make. It is not possible to go through a "trans puberty" (or, indeed, to reverse puberty once you have experienced it). You go through the puberty appropriate to the sexed body you have, or you don't. This is another of the lies being told to these confused children. Puberty is a one-shot deal.

Also, the Tavistock have the data, they just won't release it. There was no funding issue, they were awash with cash. One of the reasons they got so deep into it was that this aspect of their work became the cash cow that funded the entire institute. But just suppose that were true? That they started a clinical trial to investigate a major intervention, then somehow didn't collect the outcome data because of funding difficulties - so they simply widened eligibility so that all referrals were entered into the "study" and went right on not collecting the data? How ethical is that?

There is no possible way that stopping a cohort of children from going through puberty to see whether they're happier that way than if they go through puberty then transition can possibly be ethical when it's a known fact that ~80% of your child-transition group would have had their gender distress clear up naturally if you didn't do anything at all, but that the puberty blockers will lock almost all of them into a trans identity. If you start with 100 subjects in each group, you'll have 99 in the child-transition group progressing to cross-sex hormones, but maybe 20 in the adult-transition group still wanting to do it when they get to that point. That might be your answer right there.

Puberty is an enormously important stage of life. It's when the body and the brain both transition from childhood to adulthood. It can be stressful and some children can become distressed. But it is necessary. It was never deemed necessary to classify it as a human right before, but it should be so classified now.* To propose taking away adult brain function, adult bone density, adult capacity for sexual pleasure and adult fertility from a group of children, things they can never get back, "just to see" if they might be happier that way than going down the Blaire White/Buck Angel route as adults is monstrous.

It's playing God. It's in the Mengele camp. To insist that this must be done now, when there is a ton of unanalysed data being sat on by researchers who know full well that the analysis would be damning not just to their pet project but to their professional careers, and there are huge gaps in the animal studies that should precede any thought of an intervention like this, is frankly inexplicable.

Try watching this, then.


* the fact that Philip Pullman, who wrote what could be the fictional treatment of this exact method of child abuse with his concept of the "severed child" being separated from his daemon, his soul, before puberty, is now beating the drum for the abuse, is completely gobsmacking to me. Even more so than Margaret Attwood.
 
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Most of this is untrue.
No, it's not.
It is strange you talk about the pituitary but leave out the gonads which are the primary source of sex hormones, and talk about the adrenals which aren't primary producers of sex hormones. Adrenarche is a different process from menarche.

May I suggest if you don't understand the (complex) process of puberty you learn about it before you opine on it.
The pituitary governs the gonads, and is responsible for triggering production of sex hormones. I know this because my godchild has Kallmann Syndrome. I've learned far more about the actual process of puberty than I ever desired to know.

Adrenarche is certainly a different process from menarche - but the two are synchronous processes occurring within the same time-bound window.
 
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Do you know the benefits? How do you know the harms if you have done no studies?
We already know the harms. The harms have been known for a long time. We know the risks associated with GnRH agonists for people with precocious puberty, fibroids, ovarian cancer, testicular cancer, and a handful of other conditions where these drugs are actually FDA approved for use. We also know the harms of normal puberty not occurring, because we know about a host of DSDs that interrupt that process with very negative effects. And the bone density issues in youth without DSDs who take blockers to treat their mental health disorder are well documented.

So we know for certain that there are harms. Absolutely, 100% known. And you want us to subject children to known harms to see if their long-term mental health improves enough to make *you* feel comfortable damaging their cognitive development, bone density, fertility, and sexual function?

Why do you feel that you have any right to demand that the government engage in borderline-eugenics experiments on other people's children?
 
I know I disagree with Rolfe and Emily's Cat, but as a woman who had gender dysphoria as a teenager and grew out of it, I am mostly on their side. All I am saying is that partitioning off gender dysphoria as no go zone for scientific research is not a good thing. Teen females and I guess teen males suffer from this, it can contribute to suicide, it is not a trivial thing you grow out of for some persons. It is a genuine area for research, but it is a difficult area as Rolfe and Emily's Cat demonstrate.
If there weren't known serious harms associated with blockers, then it would be reasonable to conduct trials. But the negative impacts aren't a mystery - they're well documented across multiple different conditions including those poor youth who were given them to address mental health distress.

There's no evidence of long-lasting mental health improvement. Furthermore, there are already thousands of youth who were given blockers who haven't been followed up on to evaluate their outcomes.
 
Anecdotal evidence is low level evidence. Why won't you allow research to be done? I have actually done endocrine clinics dealing with people who are transitioning, so I do have some understanding of the issues; but I wouldn't claim to be an expert. My anecdotal evidence is I don't think transitioning is a great option but for some people it may be the best of available options.

Whilst I appreciate Rolfe and Emily's cat have strong views on the harms caused from puberty blockers, reviews don't support their opinions. the evidence for harms or benefits is not strong. Clearly indicating the need for further research (COI statement I am not currently nor have I previously done research in this area, I am not currently applying for grants to research gender dysphoria.)

Planigale, I appreciate where you're coming from. But are you actually trying to claim that the harms associated with GnRH agonists are unknown or have only weak evidence? Are you claiming that the harms of a pubertal child NOT acreting bone density within the growth window governed by the adrenal are unknown or have weak evidence?

Honestly, you're looking at this through a mostly closed window. You're looking exclusively and only at their use within the context of dysphoria... and ignoring the already known risks and harms that are well established. So unless you think that kids with dysphoria have an extra special internal protection against those harms, and have some heretofore unknown mechanism for bone density accretion... I think you're being willfully ignorant.
 
You accept that there may be individuals who have better lives if they transition, but they then deserve the research on the best way to transition.
Very serious question for you.

We already know that GnRH agonists cause harm, including low bone density that can't be overcome, loss of fertility, and loss of sexual function.
We already know that if left unmedicalized, over 80% of youth experiencing dysphoria will resolve their distress in the course of a normal puberty.

By what rationale do you think that 80% of the participants should be subjected to known harms in order to find out if 20% of the participants experience lasting improvements to their mental distress?
 

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